scholarly journals Familial Hypercholesterolemia: a Review of the Natural History, Diagnosis, and Management

2015 ◽  
Vol 4 (1) ◽  
pp. 25-38 ◽  
Author(s):  
Osman Najam ◽  
Kausik K. Ray
Keyword(s):  
Natural History ◽  
Familial Hypercholesterolemia ◽  
Diagnosis And Management

scholarly journals COVID-19 pandemic: the implications of the natural history, challenges of diagnosis and management for care in sub-Saharan Africa

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Lawrence Omo-Aghoja ◽  
Emuesiri Goodies Moke ◽  
Kenneth Kelechi Anachuna ◽  
Adrian Itivere Omogbiya ◽  
Emuesiri Kohworho Umukoro ◽  
...  
Keyword(s):  
Public Health ◽  
Natural History ◽  
Low Income ◽  
Sub Saharan Africa ◽  
Low Income Countries ◽  
Diagnosis And Management ◽  
Severe Acute Respiratory Infection ◽  
Identification Technique ◽  
Sub Saharan ◽  
Policies And Programs

Abstract Background Coronavirus disease (COVID-19) is a severe acute respiratory infection which has afflicted virtually almost all nations of the earth. It is highly transmissible and represents one of the most serious pandemics in recent times, with the capacity to overwhelm any healthcare system and cause morbidity and fatality. Main content The diagnosis of this disease is daunting and challenging as it is dependent on emerging clinical symptomatology that continues to increase and change very rapidly. The definitive test is the very expensive and scarce polymerase chain reaction (PCR) viral identification technique. The management has remained largely supportive and empirical, as there are no officially approved therapeutic agents, vaccines or antiviral medications for the management of the disease. Severe cases often require intensive care facilities and personnel. Yet there is paucity of facilities including the personnel required for diagnosis and treatment of COVID-19 in sub-Saharan Africa (SSA). It is against this backdrop that a review of key published reports on the pandemic in SSA and globally is made, as understanding the natural history of a disease and the documented responses to diagnosis and management is usually a key public health strategy for designing and improving as appropriate, relevant interventions. Lead findings were that responses by most nations of SSA were adhoc, paucity of public health awareness strategies and absence of legislations that would help enforce preventive measures, as well as limited facilities (including personal protective equipment) and institutional capacities to deliver needed interventions. Conclusion COVID-19 is real and has overwhelmed global health care system especially low-income countries of the sub-Sahara such as Nigeria. Suggestions for improvement of healthcare policies and programs to contain the current pandemic and to respond more optimally in case of future pandemics are made herein.

scholarly journals Current Diagnosis and Management of Cervical Spondylotic Myelopathy

2017 ◽  
Vol 7 (6) ◽  
pp. 572-586 ◽  
Author(s):  
Joshua Bakhsheshian ◽  
Vivek A. Mehta ◽  
John C. Liu
Keyword(s):  
Natural History ◽  
Cervical Spondylotic Myelopathy ◽  
Early Recognition ◽  
Clinical Manifestations ◽  
High Quality ◽  
Diagnosis And Management ◽  
Imaging Characteristics ◽  
Cervical Sagittal Alignment ◽  
Long Term Follow Up ◽  
The Cost

Study Design: Review. Objectives: Cervical spondylotic myelopathy (CSM) is a major cause of disability, particular in elderly patients. Awareness and understanding of CSM is imperative to facilitate early diagnosis and management. This review article addresses CSM with regard to its epidemiology, anatomical considerations, pathophysiology, clinical manifestations, imaging characteristics, treatment approaches and outcomes, and the cost-effectiveness of surgical options. Methods: The authors performed an extensive review of the peer-reviewed literature addressing the aforementioned objectives. Results: The clinical presentation and natural history of CSM is variable, alternating between quiescent and insidious to stepwise decline or rapid neurological deterioration. For mild CSM, conservative options could be employed with careful observation. However, surgical intervention has shown to be superior for moderate to severe CSM. The success of operative or conservative management of CSM is multifactorial and high-quality studies are lacking. The optimal surgical approach is still under debate, and can vary depending on the number of levels involved, location of the pathology and baseline cervical sagittal alignment. Conclusions: Early recognition and treatment of CSM, before the onset of spinal cord damage, is essential for optimal outcomes. The goal of surgery is to decompress the cord with expansion of the spinal canal, while restoring cervical lordosis, and stabilizing when the risk of cervical kyphosis is high. Further high-quality randomized clinical studies with long-term follow up are still needed to further define the natural history and help predict the ideal surgical strategy.

scholarly journals Familial Hypercholesterolemia in Asia Pacific: A Review of Epidemiology, Diagnosis, and Management in the Region

2021 ◽  
Author(s):  
Sanjay Kalra ◽  
Zhenyue Chen ◽  
Chaicharn Deerochanawong ◽  
Kou-Gi Shyu ◽  
Ru San Tan ◽  
...  
Keyword(s):  
Familial Hypercholesterolemia ◽  
Asia Pacific ◽  
Diagnosis And Management

scholarly journals Symptomatic intracranial arterial disease: incidence, natural history, diagnosis, and management

2011 ◽  
Vol 30 (6) ◽  
pp. E14 ◽  
Author(s):  
Ananth K. Vellimana ◽  
Andria L. Ford ◽  
Jin-Moo Lee ◽  
Colin P. Derdeyn ◽  
Gregory J. Zipfel
Keyword(s):  
Natural History ◽  
Medical Therapy ◽  
Endovascular Therapy ◽  
Medical Management ◽  
Surgical Intervention ◽  
Disease Incidence ◽  
Arterial Disease ◽  
High Rate ◽  
Diagnosis And Management ◽  
Ischemic Events

Symptomatic intracranial arterial disease is associated with a high rate of recurrent ischemic events. The management of this condition is controversial, with some advocating medical therapy as a sole means of treatment and others recommending endovascular therapy in addition to best medical management. In rare cases, surgical intervention is considered. A thorough review of the available literature was performed, and treatment recommendations based on these data are provided.

Natural History, Diagnosis, and Management of Type II Endoleaks after Endovascular Aortic Repair: Review and Update

2020 ◽  
Vol 62 ◽  
pp. 420-431 ◽  
Author(s):  
Mario D’Oria ◽  
Davide Mastrorilli ◽  
Barbara Ziani
Keyword(s):  
Natural History ◽  
Endovascular Aortic Repair ◽  
Type Ii ◽  
Diagnosis And Management ◽  
Aortic Repair

Heparin-induced thrombocytopenia: natural history, diagnosis, and management

2001 ◽  
Vol 6 (2) ◽  
pp. 113-119 ◽  
Author(s):  
S.R. Deitcher ◽  
T.L. Carman
Keyword(s):  
Natural History ◽  
Heparin Induced Thrombocytopenia ◽  
Diagnosis And Management

scholarly journals NLA Recommendations for the Diagnosis and Management of Familial Hypercholesterolemia in Children and Adults

2011 ◽  
Vol 5 (6) ◽  
pp. S2-S3 ◽  
Author(s):  
Samuel S. Giddings ◽  
Anne C. Goldberg ◽  
Matthew K. Ito ◽  
Jennifer G. Robinson ◽  
Peter P. Toth
Keyword(s):  
Familial Hypercholesterolemia ◽  
Diagnosis And Management

Familial Hypercholesterolemia: Screening, diagnosis and management of pediatric and adult patients

2011 ◽  
Vol 5 (3) ◽  
pp. S1-S8 ◽  
Author(s):  
Anne C. Goldberg ◽  
Paul N. Hopkins ◽  
Peter P. Toth ◽  
Christie M. Ballantyne ◽  
Daniel J. Rader ◽  
...  
Keyword(s):  
Familial Hypercholesterolemia ◽  
Adult Patients ◽  
Diagnosis And Management
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