Effect of Short-Term Fasting on Systemic Cytochrome P450-Mediated Drug Metabolism in Healthy Subjects: A Randomized, Controlled, Crossover Study Using a Cocktail Approach

Laureen A. Lammers; Roos Achterbergh; Ron H. N. van Schaik; Johannes A. Romijn; Ron A. A. Mathôt

doi:10.1007/s40262-017-0515-7

Effect of Short-Term Fasting on Systemic Cytochrome P450-Mediated Drug Metabolism in Healthy Subjects: A Randomized, Controlled, Crossover Study Using a Cocktail Approach

Clinical Pharmacokinetics ◽

10.1007/s40262-017-0515-7 ◽

2017 ◽

Vol 56 (10) ◽

pp. 1231-1244 ◽

Cited By ~ 9

Author(s):

Laureen A. Lammers ◽

Roos Achterbergh ◽

Ron H. N. van Schaik ◽

Johannes A. Romijn ◽

Ron A. A. Mathôt

Keyword(s):

Cytochrome P450 ◽

Drug Metabolism ◽

Crossover Study ◽

Healthy Subjects ◽

Short Term ◽

Randomized Controlled ◽

Cocktail Approach

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Nutritional Status Differentially Alters Cytochrome P450 3A4 (CYP3A4) and Uridine 5′-Diphospho-Glucuronosyltransferase (UGT) Mediated Drug Metabolism: Effect of Short-Term Fasting and High Fat Diet on Midazolam Metabolism

European Journal of Drug Metabolism and Pharmacokinetics ◽

10.1007/s13318-018-0487-5 ◽

2018 ◽

Vol 43 (6) ◽

pp. 751-767 ◽

Cited By ~ 1

Author(s):

Laureen A. Lammers ◽

Roos Achterbergh ◽

Johannes A. Romijn ◽

Ron A. A. Mathôt

Keyword(s):

Cytochrome P450 ◽

Drug Metabolism ◽

Nutritional Status ◽

High Fat Diet ◽

Cytochrome P450 3A4 ◽

High Fat ◽

Short Term ◽

Midazolam Metabolism

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Effect of fermented red ginseng on cytochrome P450 and P‐glycoprotein activity in healthy subjects, as evaluated using the cocktail approach

British Journal of Clinical Pharmacology ◽

10.1111/bcp.13080 ◽

2016 ◽

Vol 82 (6) ◽

pp. 1580-1590 ◽

Cited By ~ 15

Author(s):

Min‐Gul Kim ◽

Yunjeong Kim ◽

Ji‐Young Jeon ◽

Dal‐Sik Kim

Keyword(s):

Cytochrome P450 ◽

Healthy Subjects ◽

Red Ginseng ◽

P Glycoprotein ◽

Cocktail Approach

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Effect of cenobamate on the single‐dose pharmacokinetics of multiple cytochrome P450 probes using a cocktail approach in healthy subjects

Clinical and Translational Science ◽

10.1111/cts.13204 ◽

2021 ◽

Author(s):

Stephen A. Greene ◽

Charles Kwak ◽

Marc Kamin ◽

Laurent Vernillet ◽

Kelli J. Glenn ◽

...

Keyword(s):

Cytochrome P450 ◽

Single Dose ◽

Healthy Subjects ◽

Cocktail Approach

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SHORT-TERM INHIBITORY EFFECTS OF NITRIC OXIDE ON CYTOCHROME P450-MEDIATED DRUG METABOLISM: TIME DEPENDENCY AND REVERSIBILITY PROFILES IN ISOLATED PERFUSED RAT LIVERS

Drug Metabolism and Disposition ◽

10.1124/dmd.104.001487 ◽

2004 ◽

Vol 32 (12) ◽

pp. 1446-1454 ◽

Cited By ~ 23

Author(s):

Ragini Vuppugalla ◽

Reza Mehvar

Keyword(s):

Nitric Oxide ◽

Cytochrome P450 ◽

Drug Metabolism ◽

Time Dependency ◽

Inhibitory Effects ◽

Short Term ◽

Rat Livers

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The Acute Effects Of Nasal High Flow On Respiratory Functions In Healthy Subjects: A Randomized Controlled Crossover Study

10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5782 ◽

2012 ◽

Author(s):

Hartmut Schneider ◽

Sheng Feng ◽

Stanislav Tatkov ◽

Toby Mundel

Keyword(s):

Crossover Study ◽

Healthy Subjects ◽

High Flow ◽

Acute Effects ◽

Randomized Controlled

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Double-blind crossover study to assess potential differences in cytochrome P450 3A4 activity in healthy subjects receiving ondansetron plus dexamethasone, with and without aprepitant

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-010-1421-y ◽

2010 ◽

Vol 67 (6) ◽

pp. 1313-1321 ◽

Cited By ~ 7

Author(s):

S. Aubrey Stoch ◽

Cynthia Gargano ◽

Jack Valentine ◽

Matthew P. Braun ◽

M. Gail Murphy ◽

...

Keyword(s):

Cytochrome P450 ◽

Crossover Study ◽

Healthy Subjects ◽

Cytochrome P450 3A4 ◽

Double Blind ◽

Blind Crossover Study ◽

Double Blind Crossover Study

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Short-Term Fasting Alters Cytochrome P450–Mediated Drug Metabolism in Humans

Drug Metabolism and Disposition ◽

10.1124/dmd.114.062299 ◽

2015 ◽

Vol 43 (6) ◽

pp. 819-828 ◽

Cited By ~ 16

Author(s):

Laureen A. Lammers ◽

Roos Achterbergh ◽

Emmely M. de Vries ◽

F. Samuel van Nierop ◽

Heinz-Josef Klümpen ◽

...

Keyword(s):

Cytochrome P450 ◽

Drug Metabolism ◽

Short Term

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Effect of Telavancin on the Pharmacokinetics of the Cytochrome P450 3A Probe Substrate Midazolam: A Randomized, Double-Blind, Crossover Study in Healthy Subjects

Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy ◽

10.1592/phco.30.2.136 ◽

2010 ◽

Vol 30 (2) ◽

pp. 136-143 ◽

Cited By ~ 17

Author(s):

Shekman L Wong ◽

Michael R Goldberg ◽

Charles H Ballow ◽

Michael M Kitt ◽

Steven L Barriere

Keyword(s):

Cytochrome P450 ◽

Crossover Study ◽

Healthy Subjects ◽

Cytochrome P450 3A ◽

Double Blind ◽

Blind Crossover Study ◽

Double Blind Crossover Study

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Faculty Opinions recommendation of Population pharmacokinetics and pharmacodynamics of continuous versus short-term infusion of imipenem-cilastatin in critically ill patients in a randomized, controlled trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1099302.555530 ◽

2008 ◽

Author(s):

Mathias Pletz

Keyword(s):

Randomized Controlled Trial ◽

Population Pharmacokinetics ◽

Critically Ill ◽

Critically Ill Patients ◽

Controlled Trial ◽

Pharmacokinetics And Pharmacodynamics ◽

Short Term ◽

Population Pharmacokinetics And Pharmacodynamics ◽

Randomized Controlled

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Faculty Opinions recommendation of Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13266960.14785093 ◽

2011 ◽

Author(s):

Thomas Slaughter

Keyword(s):

Crossover Study ◽

Healthy Subjects ◽

Prothrombin Complex Concentrate

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