Hepatotoxicity of vascular endothelial growth factor receptor tyrosine kinase inhibitors: clinical practice and evidence

Bulent Cetin; Irem Bilgetekin; Mustafa Cengiz; Ahmet Ozet

doi:10.1007/s40267-017-0416-8

Hepatotoxicity of vascular endothelial growth factor receptor tyrosine kinase inhibitors: clinical practice and evidence

Drugs & Therapy Perspectives ◽

10.1007/s40267-017-0416-8 ◽

2017 ◽

Vol 33 (8) ◽

pp. 395-402

Author(s):

Bulent Cetin ◽

Irem Bilgetekin ◽

Mustafa Cengiz ◽

Ahmet Ozet

Keyword(s):

Vascular Endothelial Growth Factor ◽

Clinical Practice ◽

Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

Naphthamides as Novel and Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Design, Synthesis, and Evaluation¶

Journal of Medicinal Chemistry ◽

10.1021/jm701097z ◽

2008 ◽

Vol 51 (6) ◽

pp. 1649-1667 ◽

Cited By ~ 43

Author(s):

Jean-Christophe Harmange ◽

Matthew M. Weiss ◽

Julie Germain ◽

Anthony J. Polverino ◽

George Borg ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Design Synthesis ◽

Endothelial Growth Factor ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

PotentN-(1,3-Thiazol-2-yl)pyridin-2-amine Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors with Excellent Pharmacokinetics and Low Affinity for the hERG Ion Channel

Journal of Medicinal Chemistry ◽

10.1021/jm049697f ◽

2004 ◽

Vol 47 (25) ◽

pp. 6363-6372 ◽

Cited By ~ 40

Author(s):

Mark T. Bilodeau ◽

Adrienne E. Balitza ◽

Timothy J. Koester ◽

Peter J. Manley ◽

Leonard D. Rodman ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinase ◽

Ion Channel ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

Vascular endothelial growth factor receptor tyrosine kinase inhibitors: PTK787/ZK 222584

Seminars in Oncology ◽

10.1016/s0093-7754(03)00123-4 ◽

2003 ◽

Vol 30 (3 Suppl 6) ◽

pp. 32-38 ◽

Cited By ~ 32

Author(s):

Anne L. Thomas ◽

Bruno Morgan ◽

Joachim Drevs ◽

Clemens Unger ◽

Bertram Wiedenmann ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

Vascular endothelial growth factor receptor tyrosine kinase inhibitors: PTK787/ZK 222584

Seminars in Oncology ◽

10.1016/s0093-7754(03)70023-2 ◽

2003 ◽

Vol 30 (3) ◽

pp. 32-38 ◽

Cited By ~ 62

Author(s):

A THOMAS ◽

B MORGAN ◽

J DREVS ◽

C UNGER ◽

B WIEDENMANN ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

Pancreatitis with vascular endothelial growth factor receptor tyrosine kinase inhibitors.

Journal of Clinical Oncology ◽

10.1200/jco.2014.32.15_suppl.e13547 ◽

2014 ◽

Vol 32 (15_suppl) ◽

pp. e13547-e13547

Author(s):

Pooja Ghatalia ◽

Charity Morgan ◽

Toni K. Choueiri ◽

Pedro Rocha ◽

Gurudatta Naik ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors Vandetanib (ZD6474) and AZD2171 in Lung Cancer

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-07-0539 ◽

2007 ◽

Vol 13 (15) ◽

pp. 4617s-4622s ◽

Cited By ~ 36

Author(s):

Emer O. Hanrahan ◽

John V. Heymach

Keyword(s):

Lung Cancer ◽

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

The Emerging Role of Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors

Seminars in Oncology ◽

10.1053/j.seminoncol.2005.10.005 ◽

2005 ◽

Vol 32 ◽

pp. 23-29 ◽

Cited By ~ 17

Author(s):

Corey J. Langer ◽

Ronald B. Natale

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinase ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

Endoscopy in patients with diarrhea during treatment with vascular endothelial growth factor receptor tyrosine kinase inhibitors: Is the cause in the mucosa?

Acta Oncologica ◽

10.3109/0284186x.2015.1119883 ◽

2016 ◽

Vol 55 (4) ◽

pp. 444-448 ◽

Cited By ~ 1

Author(s):

Marye J. Boers-Sonderen ◽

Sasja F. Mulder ◽

Iris D. Nagtegaal ◽

Lauranne A. A. P. Derikx ◽

Geert J. A. Wanten ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

Pancreatitis with vascular endothelial growth factor receptor tyrosine kinase inhibitors

Critical Reviews in Oncology/Hematology ◽

10.1016/j.critrevonc.2014.11.008 ◽

2015 ◽

Vol 94 (1) ◽

pp. 136-145 ◽

Cited By ~ 20

Author(s):

Pooja Ghatalia ◽

Charity J. Morgan ◽

Toni K. Choueiri ◽

Pedro Rocha ◽

Gurudatta Naik ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitors ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text

Risks of Proteinuria Associated with Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors in Cancer Patients: A Systematic Review and Meta-Analysis

PLoS ONE ◽

10.1371/journal.pone.0090135 ◽

2014 ◽

Vol 9 (3) ◽

pp. e90135 ◽

Cited By ~ 31

Author(s):

Ze-Feng Zhang ◽

Tao Wang ◽

Li-Hua Liu ◽

Hui-Qin Guo

Keyword(s):

Systematic Review ◽

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Receptor Tyrosine Kinase ◽

Kinase Inhibitors ◽

Meta Analysis ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Receptor Tyrosine Kinase Inhibitors

Download Full-text