Systemic FQs linked with aortic aneurysm, dissection?

Aortitis is one of the manifestations of giant cell arteritis (GCA) and is included in its definition. There is a significantly increased risk of aortic aneurysm formation in GCA patients. In some GCA patients aortic aneurysm dissection is diagnosed only in autopsy. Monitoring of these patients, especially in long lasting disease, requires a doctor’s awareness of the possibility of aneurysm formation and aortic aneurysm dissection. Based on the available reports it cannot be confirmed whether intensification of aortitis treatment in GCA prevents the development of aneurysms. This article presents an overview of the available literature and our own experience on a rational diagnosis of inflammation and aneurysms of the aorta in GCA, as well as the prospects for its prevention.

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Is Emilin-1 a molecular link contributing to the extension of thoracic aortic aneurysm dissection and increasing the magnitude of the associated hypertension

Integrative Molecular Medicine ◽

10.15761/imm.1000254 ◽

2016 ◽

Vol 3 (6) ◽

Author(s):

Simon W Rabkin

Keyword(s):

Aortic Aneurysm ◽

Thoracic Aortic Aneurysm ◽

Aneurysm Dissection

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Giant coronary aneurysm in a patient with familial aortic aneurysm/dissection: Medial degeneration extending to coronary artery

Journal of Cardiology Cases ◽

10.1016/j.jccase.2009.10.003 ◽

2010 ◽

Vol 1 (2) ◽

pp. e124-e127 ◽

Cited By ~ 1

Author(s):

Yoshihiro Morino ◽

Jun Asada ◽

Taiichi Yamamoto ◽

Yoshio Oh-hashi ◽

Atsushi Yamaguchi ◽

...

Keyword(s):

Coronary Artery ◽

Aortic Aneurysm ◽

Coronary Aneurysm ◽

Giant Coronary Aneurysm ◽

Medial Degeneration ◽

Aneurysm Dissection

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A Rare Life-Threatening Cause of Hemoptysis: Aortic Aneurysm Dissection

CHEST Journal ◽

10.1378/chest.1702768 ◽

2013 ◽

Vol 144 (4) ◽

pp. 337A

Author(s):

Min-Hui Chen ◽

Ravindra Rajmane

Keyword(s):

Aortic Aneurysm ◽

Life Threatening ◽

Aneurysm Dissection

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A Case Based Approach to Clinical Genetics of Thoracic Aortic Aneurysm/Dissection

BioMed Research International ◽

10.1155/2016/9579654 ◽

2016 ◽

Vol 2016 ◽

pp. 1-10 ◽

Cited By ~ 5

Author(s):

Betti Giusti ◽

Stefano Nistri ◽

Elena Sticchi ◽

Rosina De Cario ◽

Rosanna Abbate ◽

...

Keyword(s):

Aortic Aneurysm ◽

Thoracic Aortic Aneurysm ◽

State Of The Art ◽

Genetic Profile ◽

Clinical Genetics ◽

Clinical Genetic ◽

Increased Risk ◽

Rising Incidence ◽

Aneurysm Dissection

Thoracic aortic aneurysm/dissection (TAAD) is a potential lethal condition with a rising incidence. This condition may occur sporadically; nevertheless, it displays familial clustering in >20% of the cases. Family history confers a six- to twentyfold increased risk of TAAD and has to be considered in the identification and evaluation of patients needing an adequate clinical follow-up. Familial TAAD recognizes a number of potential etiologies with a significant genetic heterogeneity, in either syndromic or nonsyndromic forms of the manifestation. The clinical impact and the management of patients with TAAD differ according to the syndromic and nonsyndromic forms of the manifestation. The clinical management of TAAD patients varies, depending on the different forms. Starting from the description of patient history, in this paper, we summarized the state of the art concerning assessment of clinical/genetic profile and therapeutic management of TAAD patients.

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Large-vessel involvement in giant cell arteritis: a population-based cohort study of the incidence-trends and prognosis

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2012-202408 ◽

2012 ◽

Vol 72 (12) ◽

pp. 1989-1994 ◽

Cited By ~ 148

Author(s):

Tanaz A Kermani ◽

Kenneth J Warrington ◽

Cynthia S Crowson ◽

Steven R Ytterberg ◽

Gene G Hunder ◽

...

Keyword(s):

Aortic Aneurysm ◽

General Population ◽

Giant Cell Arteritis ◽

Giant Cell ◽

Population Based ◽

Artery Stenosis ◽

Large Vessel ◽

Large Artery ◽

Incidence Trends ◽

Aneurysm Dissection

ObjectivesTo evaluate incidence-trends and timing of large-vessel (LV) manifestations in patients with giant cell arteritis (GCA), and to examine the influence of LV manifestations on survival.MethodsA population-based incident cohort of patients diagnosed with GCA between 1950 and 2004 was used. LV involvement was defined as large-artery stenosis or aortic aneurysm/dissection that developed in the 1 year before GCA diagnosis or at any time thereafter. Patients were followed up until death or 31 December 2009.ResultsThe study included 204 patients, 80% women, mean age at diagnosis of GCA 76.0 years (±8.2 years). Median length of follow-up was 8.8 years. The cumulative incidence of any LV manifestation at 10 years was 24.9% for patients diagnosed with GCA between 1980 and 2004 compared with 8.3% for patients diagnosed with GCA between 1950 and 1979. The incidence of any LV event was high within the first year of GCA diagnosis. The incidence of aortic aneurysm/dissection increased 5 years after GCA diagnosis. Compared with the general population, survival was decreased in patients with an aortic aneurysm/dissection (standardized mortality ratio (SMR) 2.63; 95% CI 1.78 to 3.73) but not in patients with large-artery stenosis (SMR 1.44; 95% CI 0.87 to 2.25). Patients with GCA and aortic manifestations had a higher than expected number of deaths from cardiovascular and pulmonary causes than the general population. Among patients with GCA, aortic manifestations were associated with increased mortality (HR=3.4; 95% CI 2.2 to 5.4).ConclusionsVigilance and screening for aortic aneurysms should be considered in all patients 5 years after the incidence of GCA. Aortic aneurysm/dissection is associated with increased mortality in GCA.

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