The association of cytotoxic T-lymphocyte antigen-4 + 49A/G and CT60 polymorphisms with type 1 diabetes and latent autoimmune diabetes in Chinese adults

2014 ◽  
Vol 38 (2) ◽  
pp. 149-154 ◽  
Author(s):  
P. Jin ◽  
B. Xiang ◽  
G. Huang ◽  
Z. Zhou
Keyword(s):  
Type 1 Diabetes ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Autoimmune Diabetes ◽  
Chinese Adults ◽  
Lymphocyte Antigen ◽  
Latent Autoimmune Diabetes

scholarly journals Cytotoxic T-lymphocyte antigen-4 +49A/G polymorphisms in Sudanese adults with type 1 diabetes and latent autoimmune diabetes

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Shimos A. Alshareef ◽  
Saeed M. Omar ◽  
Hamdan Z. Hamdan ◽  
Ishag Adam
Keyword(s):  
Type 1 Diabetes ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Autoimmune Diabetes ◽  
Heterozygous Mutation ◽  
Latent Autoimmune Diabetes ◽  
Pcr Rflp ◽  
Polymerase Chain ◽  
Eastern Sudan

Abstract Objectives This study was conducted to assess the association of T-lymphocyte-associated protein 4 (CTLA-4 +49A/G) variant with Latent autoimmune diabetes in adults (LADA) in Eastern Sudan. The study included 24 LADA, 240 patients with type 1 diabetes mellitus (T1DM), and 240 healthy controls. Genotyping for CTLA-4 +49A/G was done by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Results Genotypes distribution of CTLA-4 in controls was in accordance with the HWE (P > 0.05). The frequency of mutation (both homozygous and heterozygous) of CTLA-4 +49A/G (AG + GG) was significantly higher in LADA compared with T1DM and the controls [19 (79.1%) vs. 100 (41.7%) vs. 78 (32.5%), P < 0.001]. It was significantly higher when LADA was compared with T1DM [19 (79.1%) vs. 100 (41.7%), P = 0.018, OR = 3.21, 95% CI 1.16–8.89] and when LADA was compared with the controls [19 (79.1%) vs. 78 (32.5%), P = 0.001, OR = 4.49, 95% CI 1.62–12.42]. The rate of heterozygous mutation of the CTLA-4 +49A/G (AG) was significantly higher in LADA compared with T1DM and the controls [16 (66.7%) vs. 85 (35.4%) vs. 70 (29.2%), P < 0.001]. It was significantly higher when LADA was compared with T1DM [16 (66.7%) vs. 85 (35.4%), P = 0.002, OR = 3.64, 95% CI 1.49–8.87] and when LADA was compared with the controls [16 (66.6%) vs. 85 (35.4%), P = 0.001, OR = 4.85, 95% CI 1.98–11.86].

Interactions between programmed death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) gene polymorphisms in type 1 diabetes

2009 ◽  
Vol 83 (3) ◽  
pp. 289-294 ◽  
Author(s):  
Scherezade Momin ◽  
Sylvia Flores ◽  
Bárbara Angel B ◽  
Ethel Codner D ◽  
Elena Carrasco P ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Lymphocyte ◽  
Gene Polymorphisms ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Antigen ◽  
Programmed Death ◽  
Programmed Death 1

Association between cytotoxic T lymphocyte antigen-4 polymorphism and type 1 diabetes: A meta-analysis

Gene ◽  
2013 ◽  
Vol 516 (2) ◽  
pp. 263-270 ◽  
Author(s):  
Zixian Chen ◽  
Min Fei ◽  
Da Fu ◽  
Liang Zhang ◽  
Yushui Ma ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Meta Analysis ◽  
Lymphocyte Antigen

Cytotoxic T lymphocyte antigen 4 heterozygous codon 49 A/G dimorphism is associated to latent autoimmune diabetes in adults (LADA)

Autoimmunity ◽  
2005 ◽  
Vol 38 (4) ◽  
pp. 277-281 ◽  
Author(s):  
Mariela Caputo ◽  
Gloria Edith Cerrone ◽  
Ariel Pablo López ◽  
Anabel Villalba ◽  
Gabriela Andrea Krochik ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Autoimmune Diabetes ◽  
Lymphocyte Antigen ◽  
Latent Autoimmune Diabetes
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