Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura

2018 ◽  
Vol 31 (5) ◽  
pp. 731-741 ◽  
Author(s):  
Annamaria Milillo ◽  
Clelia Molinario ◽  
Stefano Costanzi ◽  
Gisella Vischini ◽  
Francesca La Carpia ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Erk Pathway ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura ◽  
Common Defect

scholarly journals Renal Outcomes of Childhood IgA Nephropathy and Henoch Schönlein Purpura Nephritis

2021 ◽  
Vol 73 (10) ◽  
pp. 687-694
Author(s):  
Thanaporn Chaiyapak ◽  
Anirut Pattaragarn ◽  
Suroj Supavekin ◽  
Nuntawan Piyaphanee ◽  
Kraisoon Lomjansook ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Complete Recovery ◽  
Clinicopathological Characteristics ◽  
Henoch Schonlein Purpura ◽  
Renal Outcomes ◽  
Nephritic Syndrome ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura ◽  
Purpura Nephritis

Background: Henoch-Schönlein purpura nephritis (HSPN) is considered the systemic form of IgA nephropathy (IgAN). However, differing clinicopathological features and renal outcomes of children with IgAN and HSPN have been reported in some studies. Methods: This study retrospectively reviewed children with IgAN and HSPN younger than 18 years, between January 2004 and December 2015. The clinicopathological characteristics at diagnosis and the renal outcomes after at least 1 year of follow-up were compared between the two groups. Results: A total of 54 children, comprising 21 with IgAN and 33 with HSPN, were recruited. The children with HSPN were younger than the children with IgAN. Gross hematuria and nephritic syndrome at the initial presentation were more common in children with IgAN. Regarding the pathological findings, IgAN had greater chronicity than HSPN. After a median follow-up period from first presentation to renal outcomes measurement of 4.0 years (1.3-12.2) in children with IgAN and 4.2 years (1.1-11.4) in children with HSPN, the renal outcomes were better in the latter group. The incidence of chronic kidney disease (CKD) was 28.6% in children with IgAN and 6.1% in children with HSPN (p = 0.02). Complete recovery was observed more frequently in children with HSPN than in children with IgAN (57.1% in IgAN vs. 87.9% in HSPN, p = 0.01). Conclusions: Childhood IgAN has greater chronicity and worse renal outcomes than childhood HSPN, with a lower rate of complete recovery and a higher frequency of CKD. We recommend long-term follow-up for CKD in children with IgAN.

scholarly journals A cross-sectional analysis of clinicopathologic similarities and differences between Henoch-Schönlein purpura nephritis and IgA nephropathy

PLoS ONE ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. e0232194 ◽  
Author(s):  
Motonori Sugiyama ◽  
Yukihiro Wada ◽  
Nobuhiro Kanazawa ◽  
Shohei Tachibana ◽  
Taihei Suzuki ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Henoch Schonlein Purpura ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Similarities And Differences ◽  
Sectional Analysis ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura ◽  
Purpura Nephritis

Pathological improvement of IgA nephropathy and Henoch-Schönlein purpura nephritis with urokinase therapy

1996 ◽  
Vol 38 (6) ◽  
pp. 622-628 ◽  
Author(s):  
TAKESHI WATANABE ◽  
SHORI TAKAHASHI ◽  
SAORI NAKAJO ◽  
MINORU HAMASAKI
Keyword(s):  
Iga Nephropathy ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura ◽  
Purpura Nephritis

scholarly journals Urinary myeloid IgA Fc alpha receptor (CD89) and transglutaminase-2 as new biomarkers for active IgA nephropathy and henoch-Schönlein purpura nephritis

BBA Clinical ◽  
2016 ◽  
Vol 5 ◽  
pp. 79-84 ◽  
Author(s):  
Rafael N. Moresco ◽  
Marijn M. Speeckaert ◽  
Slawomir C. Zmonarski ◽  
Magdalena Krajewska ◽  
Ewa Komuda-Leszek ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Transglutaminase 2 ◽  
Henoch Schonlein Purpura ◽  
New Biomarkers ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura ◽  
Purpura Nephritis

A Case Report of Henoch-Schonlein Purpura and IgA Nephropathy Associated With Rivaroxaban

Nephrology ◽  
2018 ◽  
Vol 23 (3) ◽  
pp. 289-290 ◽  
Author(s):  
Edmund YM Chung ◽  
Jason Chen ◽  
Sarah Roxburgh
Keyword(s):  
Case Report ◽  
Iga Nephropathy ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Serum levels of galactose-deficient IgA in children with IgA nephropathy and Henoch-Schönlein purpura

2007 ◽  
Vol 22 (12) ◽  
pp. 2067-2072 ◽  
Author(s):  
Keith K. Lau ◽  
Robert J. Wyatt ◽  
Zina Moldoveanu ◽  
Milan Tomana ◽  
Bruce A. Julian ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Serum Levels ◽  
Henoch Schonlein Purpura ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura
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