scholarly journals Tolerability, course and follow-up of specific immunotherapy using a modified ultra-rush procedure in children and adolescents with insect venom allergy

2021 ◽  
Author(s):  
Jens-Oliver Steiß ◽  
Conrad Weber ◽  
Max Becker
Keyword(s):  
Quality Of Life ◽  
Quality Of Care ◽  
Maintenance Therapy ◽  
Children And Adolescents ◽  
Specific Immunotherapy ◽  
Insect Venom Allergy ◽  
Venom Allergy ◽  
Insect Venom

Summary Background Specific immunotherapy with insect venom (hymenoptera venom (HG)-AIT) is an effective and the only causal treatment for patients with systemic reactions due to IgE-mediated insect venom allergy. The present study investigated the quality of care after bee and wasp venom allergy, the tolerability of modified ultra-rush immunotherapy and the course after the conclusion of maintenance therapy in children and adolescents. Studies on the quality of life of children with insect venom allergy are scarce. Methods The efficacy, safety and tolerability of an ultra-rush protocol was analysed in 114 patients aged 4–17 years with insect venom allergy. After the end of HG-AIT, patients were contacted by questionnaire and asked to report on the quality of care as well as the course of insect venom allergy, including accidental stinging events. Quality of life was validated using the established questionnaire VQLQ‑d (Vespid Quality of Life Questionnaire), which is also used for bee venom allergy patients. Results Discontinuation of the initial therapy was not necessary in any patient. Side effects were mostly mild and did not require treatment. In 16 patients, a new sting reaction occurred during maintenance therapy, in another 15 patients a sting event was documented after cessation of HG-AIT. The intensity of the reaction to the accidental insect bite according to the severity classification after Ring and Messmer decreased from an average of 2.3 to 0.9 in these patients. This corresponds to a decrease of 61%. An emergency kit was carried by 70% of the patients, the expiry date of which, however, had already passed in almost 40% of the respondents. After the end of the therapy, most patients were not under any medical care or had never been to a check-up (92%). The evaluation of the VQLQ‑d showed a medium to low level of stress during or after therapy. Discussion Ultra-rush AIT in childhood and adolescence is safe, tolerable and effective. HG-AIT has a lasting positive effect on the health-related quality of life of patients. However, after the end of HG-AIT, there are deficits in the follow-up and care of the patients.

scholarly journals Impact of specific immunotherapy and sting challenge on the quality of life in patients with hymenoptera venom allergy

2021 ◽  
Vol 14 (5) ◽  
pp. 100536
Author(s):  
Tamara Eitel ◽  
Kim Nikola Zeiner ◽  
Katharina Assmus ◽  
Hanns Ackermann ◽  
Nadja Zoeller ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Specific Immunotherapy ◽  
Hymenoptera Venom ◽  
Venom Allergy ◽  
Hymenoptera Venom Allergy ◽  
Sting Challenge

scholarly journals Health-related quality of life in children and adolescents undergoing intraoperative device closure of isolated perimembranous ventricular septal defects in southeastern China

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Jiang-Shan Huang ◽  
Shu-Ting Huang ◽  
Kai-Peng Sun ◽  
Zhi-Nuan Hong ◽  
Liang-Wan Chen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Children And Adolescents ◽  
Health Related Quality ◽  
Ventricular Septal Defects ◽  
Device Closure ◽  
Septal Defects ◽  
Related Quality ◽  
Health Related

Abstract Objectives To investigate the health-related quality of life (HRQOL) in children and adolescents who underwent intraoperative device closure of perimembranous ventricular septal defects (pmVSDs). Methods From October 2017 to January 2018, a total of 126 children and adolescents with isolated pmVSDs who underwent intraoperative device closure were enrolled in this study. We used the Pediatric Quality of Life Inventory Measurement Models 4.0 generic core scales to measure HRQOL 24 h before the operation and three months and one year after surgery. Results A total of 126 patients were successfully occluded. No severe complications occurred during the operative time, and 1 case of Mobitz type I atrioventricular block (AVB) and 1 case of complete cAVB occurred during the postoperative period. Compared with the data before the operation, the total score and five domain scores, including physical, psychosocial, emotional, social and psychological functioning, were significantly higher at three months after the operation. In addition, the total score, physical functioning score, and the psychosocial functioning score at the 1-year follow-up were even higher than those at 3 months after the operation. Conclusions The present study suggests that intraoperative device closure of pmVSD could improve health-related quality of life in children/adolescents and that the improvement may progress as the time after the operation increases. Further studies should concentrate on comparisons with other medical methods, larger samples, and longer follow-up periods.

564 Use of the Pediatric Quality of Life Measure in the Burn Camps Population

2020 ◽  
Vol 41 (Supplement_1) ◽  
pp. S123-S123
Author(s):  
Kerry Mikolaj ◽  
Trudy Boulter ◽  
Brad Jackson ◽  
Tim Schuetz
Keyword(s):  
Quality Of Life ◽  
Children And Adolescents ◽  
Small Sample ◽  
Healthy Population ◽  
Health Related Quality ◽  
Positive Direction ◽  
Related Quality ◽  
Health Related

Abstract Introduction The Pediatric Quality of Life Inventory (PedsQL) is a tool used to measure health-related quality of life in children and adolescents. The PedsQL measures physical, emotional, social, and academic function. Our burn camp program provides comprehensive programming in a supportive, challenging environment to enhance care of a child with a burn injury. Our camp addresses: isolation, social skill development, body image, negative beliefs, risk-taking, and academic challenges. The lessons learned at camp are unique and build lifelong success. The PedsQL will provide data on changes that are being made with our campers over time. We hypothesize positive changes in PedsQL scores with the addition of burn camp. Methods The PedsQL consists of forms for children ages 2–4, 5–7, 8–12, and 13–18. Pediatric self-report is measured in children and adolescents ages 5–18. There is a separate parent proxy-report of the child’s health-related quality of life for ages 2–18. Before camp begins, parents are mailed the parent report to fill out and are due back prior to the first day of camp. Campers fill out the form on the first day of camp. Data is entered into an excel spreadsheet. Follow up parent and child/adolescent surveys are then sent out 3 months post camp. Three month follow up data is entered and compared to original scores. Three scores are generated from the data including total score, psychosocial score, and physical health score. A higher score indicates a better Health-Related Quality of Life. Results We trialed the use of the PedsQL in our adolescent burn camp, consisting of 23 campers ages 13–18. We received 8 (34%) follow up surveys. The results of these scores are trending in a positive direction. We used the PedsQL for our burn camp program consisting of 77 campers ages 8–18. We will obtain 3 month follow up data by Dec 2019 and will assess the data and report the changes. Conclusions The PedsQL is a tool that can help our camp program track changes/progress in our campers in the areas listed above. We have seen positive changes in our small sample size and predict we will see positive changes with our larger camp population in the next few months. Applicability of Research to Practice Using outcome measures for medical specialty camps is necessary and currently lacking in the literature. The PedsQL tool is used in healthy, acute and chronic health conditions, making it applicable for burn camp programs. The PedsQL has established norms for the healthy population for benchmarking purposes and community health comparisons. This tool will help our burn camp program assess the psychosocial, physical and academic growth of our campers.

scholarly journals Prospective Study on Factors Associated with Referral of Patients with Opioid Maintenance Therapy from Specialized Addictive Disorders Centers to Primary Care

2021 ◽  
Vol 18 (11) ◽  
pp. 5749
Author(s):  
Morgane Guillou-Landreat ◽  
Philippe Levassor ◽  
Marylène Guerlais ◽  
Veronique Sebille ◽  
Caroline Victorri-Vigneau
Keyword(s):  
Quality Of Life ◽  
Primary Care ◽  
Substance Use ◽  
Maintenance Therapy ◽  
Prospective Study ◽  
Substance Use Disorders ◽  
Primary Care Physicians ◽  
Addictive Disorders

Background: One of the most important issues for opiate maintenance therapy efficacy is the involvement of primary care physicians (PCPs) in opiate use disorder treatment, especially after referral from specialized units. This study aimed to analyze the progress of subjects in a specialized center and after referral to PCPs. Methods: This study was an observational prospective study. Recruitment took place in a specialized addictive disorder center in western France. All patients were evaluated (sociodemographical data, severity of substance use disorders through the TMSP scale, the quality of life through the TEAQV scale) by physicians during the 5-year-follow up of the study. Analysis focused on four main times during follow-up: entry/last visit into specialized care and into primary care. Results: 113 patients were included in this study; 93% were receiving methadone and 7% buprenorphine. Ninety (90) were referred to primary care. In primary care follow-up, the probability of the lowest severity score for substance use disorders remained stable over time. Conclusions: In daily practice, a center specialized in addictive disorders referred OMT management to PCPs for a majority of patients, and benefits regarding substance use disorders severity and quality of life remained stable after referral. Our results need to be confirmed.

Changes in health-related quality of life (HRQoL) in a population-based sample of children and adolescents after 3 years of follow-up

2008 ◽  
Vol 17 (10) ◽  
pp. 1207-1215 ◽  
Author(s):  
J. A. Palacio-Vieira ◽  
E. Villalonga-Olives ◽  
J. M. Valderas ◽  
M. Espallargues ◽  
M. Herdman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Children And Adolescents ◽  
Population Based ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals The Efficacy and Acceptability of Exposure Therapy for the Treatment of Post-Traumatic Stress Disorder in Children and Adolescents: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Haomiao Li ◽  
Tengyue Huang ◽  
Shiyu Tan ◽  
Siyu Xie ◽  
Qisheng Cheng ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Depressive Symptoms ◽  
Children And Adolescents ◽  
Social Functioning ◽  
Rating Scales ◽  
Exposure Therapy ◽  
Single Type ◽  
Severity Rating

Abstract BackgroundPosttraumatic stress disorder (PTSD) is common among children and adolescents who have experienced traumatic events. Exposure therapy (ET) has been shown to be effective in treating PTSD in adults. However, it remains uncertain in children and adolescents. AimsTo evaluate the efficacy and acceptability of ET in children and adolescents with PTSD.MethodWe searched PubMed, EMBASE, Cochrane, Web of Science, PsycINFO, CINAHL, ProQuest, LILACS, international trial registries, and others for randomised controlled trials (RCTs) assessed ET in children and adolescents (aged ≤ 18 years) with PTSD up to August 31, 2020. The primary outcomes were efficacy (the endpoint score from PTSD symptom severity rating scales) and acceptability (all-cause discontinuation), secondary outcomes included efficacy at follow-up (score from PTSD scales at the longest point of follow-up), depressive symptoms (end-point score on depressive symptom severity rating scales) and quality of life/social functioning (end-point score on quality of life/social functioning rating scales).This study was registered with PROSPERO (CRD42020150859).ResultA total of six RCTs including 278 patients assessed ET. The results showed that ET was statistically more efficacious than control groups (standardized mean differences [SMD]: −0.47, 95% confidence interval [CI]: −0.91 to −0.03). In subgroup analysis, exposure therapy was more efficacious for patients with single type of trauma (SMD: −1.04, 95%CI: −1.43 to −0.65), and the intervention using prolonged exposure therapy (PE) (SMD: −1.04, 95%CI: −1.43 to −0.65) was superior. Results for secondary outcomes of efficacy at follow-up (SMD: −0.64, 95%CI: −1.17 to −0.10) and depressive symptoms (SMD: −0.58, 95%CI: −0.93 to −0.22) were similar to the findings for efficacy outcome. No statistically significant effects for acceptability and quality of life/social functioning were found.ConclusionET showed superiority in efficacy at post-treatment/follow-up and depressive symptoms improvement in children and adolescents with PTSD. Patients with single type of trauma may benefit more from ET. Moreover, PE could be a better choice.

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