Functional Context Theory of Learning

1970 ◽  
pp. 31
Author(s):  
Bruno Ingemann

See, talk, listen – the art of experience This article presents the manner in which two informants experience an exhibition of the works of a well known Danish painter, Ole Sporring. One of the informants, Jakob (27), wears a small video camera on his head which records his walk through the exhibition, looking at the paintings and talking with his companion, Gunnar (55). Ingemann states that he has used this method in video-walks previously in the context of a cultural history museum (Ingemann 1999). A painting can be seen as an object taken from one functional context – the painter’s studio – and contextualised in an exhibition with others of his paintings, drawings, photographs and objects (Braxendale 1991). Csikszentmihalyi & Robinson have found four factors that are important when one encounters an art-work: the perceptual, the emotional, the intellectual and the communication dimensions. In their project 57 informants educated in the field of fine arts themselves chose the artworks they related to as prototypical examples. In my project I focused on informants who had no formal art history training and I myself selected the exhibition they would visit. My theoretical starting point differs from that of Csikszentmihalyi & Robin- son in that they focus on the art whereas I focus on the informants and their experience (Dewey 1934). 


Geografie ◽  
2002 ◽  
Vol 107 (3) ◽  
pp. 243-259
Author(s):  
Jiří Anděl

The aim of this article is to demonstrate the uniqueness of the territory studied and the singularity of the genesis of its settlement structure. The article attempts to outline the causes and consequences of the development within a broad spatial and functional context. The origin and development of most of the settlements that have been developing in the territory of the basin districts since the early Middle Ages, have been determined by nature, their location, but also by politics. Compared with other eras, the population of the frontier districts is distributed relatively evenly and all the particular settlements are of small extent. The critical changes took place during the periods of industrialization and subsequent urbanization. The process is shown in the synthetic part of the article (population median, concentration median etc.). Later, significant settlement centres developed in the basin area. They have kept growing since the half of the 20th century, even to the exclusion of the settlements that were demolished as a result of extensive opencast brown-coal mining.


2021 ◽  
Author(s):  
Piyali Majumder ◽  
Chinmayee Shukla ◽  
Bhaskar Datta

G-quadruplex (G4) structures have emerged as singular therapeutic targets for cancer and neurodegeneration. Autophagy is a housekeeping cellular homeostatic mechanism and deregulation of autophagy is common in cancer and in neurodegenerative diseases. In this study, we identified the presence of 46 putative G4 sequences in the MTOR gene by use of QGRS mapper tool. We sought to connect these putative G4 sequences to a functional context by leveraging G4-targeting ligands. A G4-selective dimeric carbocyanine dye Bis-4,3 and the porphyrin TMPyP4 were used to affect the replication, transcription and translation of the MTOR gene. The ligand-induced induction of autophagic pathway via MTOR gene regulation was monitored upon treatment of HeLa and SHSY-5Y cells with G4-targeting ligands. The use of Bis-4,3 was compared with the known G4-stabilizing activity of TMPyP4. Our results show that treatment with G4-selective ligands downregulates mTOR activity and leads to the induction of excessive autophagy. This is first report on effect of G4-selective ligands on MTOR regulation and mTOR expression. mTOR being the key negative regulator of autophagy, the current work suggests potential of G4 stabilizing ligands towards induction of autophagy through the downregulation of mTOR.


2017 ◽  
Author(s):  
Lester Parrott ◽  
Noreen Maguinness
Keyword(s):  

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