Effect of gallopamil on electrophysiologic abnormalities and ventricular arrhythmias associated with left ventricular hypertrophy in the feline heart

1992 ◽  
Vol 124 (4) ◽  
pp. 898-905 ◽  
Author(s):  
Peter R. Kowey ◽  
Robert O'Brien ◽  
Ying Wu ◽  
Joseph Sewter ◽  
Alexis Sokil ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Arrhythmias ◽  
Ventricular Hypertrophy ◽  
Left Ventricular

scholarly journals Is hypertensive left ventricular hypertrophy a cause of sustained ventricular arrhythmias in humans?

2021 ◽  
Author(s):  
R. Nadarajah ◽  
P. A. Patel ◽  
M. H. Tayebjee
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Arrhythmias ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Systemic Hypertension ◽  
Electrolyte Disturbance ◽  
Electrocardiographic Monitoring ◽  
Homogenous Distribution ◽  
Artery Disease ◽  
Asymptomatic Coronary Artery Disease

AbstractSudden cardiac death (SCD) is most commonly secondary to sustained ventricular arrhythmias (VAs). This review aimed to evaluate if left ventricular hypertrophy (LVH) secondary to systemic hypertension in humans is an isolated risk factor for ventricular arrhythmogenesis. Animal models of hypertensive LVH have shown changes in ion channel function and distribution, gap junction re-distribution and fibrotic deposition. Clinical data has consistently exhibited an increase in prevalence and complexity of non-sustained VAs on electrocardiographic monitoring. However, there is a dearth of trials suggesting progression to sustained VAs and SCD, with extrapolations being confounded by presence of co-existent asymptomatic coronary artery disease (CAD). Putatively, this lack of data may be due to the presence of more homogenous distribution of pathophysiological changes seen in those with hypertensive LVH versus known pro-arrhythmic conditions such as HCM and myocardial infarction. The overall impression is that sustained VAs in the context of hypertensive LVH are most likely to be precipitated by other causes such as CAD or electrolyte disturbance.

Risk of ventricular arrhythmias in left ventricular hypertrophy: The Framingham Heart Study

1987 ◽  
Vol 60 (7) ◽  
pp. 560-565 ◽  
Author(s):  
Daniel Levy ◽  
Keaven M. Anderson ◽  
Daniel D. Savage ◽  
Susan A. Balkus ◽  
William B. Kannel ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Framingham Heart Study ◽  
Ventricular Arrhythmias ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Heart Study

Significance of ventricular arrhythmias in systemic hypertension with left ventricular hypertrophy

1992 ◽  
Vol 69 (9) ◽  
pp. 913-917 ◽  
Author(s):  
Stuart D. Pringle ◽  
Francis G. Dunn ◽  
Peter W. Macfarlane ◽  
James H. McKillop ◽  
A.Ross Lorimer ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Arrhythmias ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Systemic Hypertension
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