Interaction of calcium and isoproterenol on the ventricular action potential in depolarized guinea pig myocardium

1975 ◽  
Vol 35 (1) ◽  
pp. 163
Author(s):  
Wanda Poplawska ◽  
Borys Surawlcz
Keyword(s):  
Guinea Pig ◽  
Action Potential ◽  
Ventricular Action Potential

scholarly journals Inhibition of HERG K + Current and Prolongation of the Guinea‐Pig Ventricular Action Potential by 4‐Aminopyridine

2003 ◽  
Vol 549 (3) ◽  
pp. 667-672 ◽  
Author(s):  
J. M. Ridley ◽  
J. T. Milnes ◽  
Y. H. Zhang ◽  
H. J. Witchel ◽  
J. C. Hancox
Keyword(s):  
Guinea Pig ◽  
Action Potential ◽  
K Current ◽  
Ventricular Action Potential

scholarly journals Rate dependency of delayed rectifier currents during the guinea‐pig ventricular action potential

2001 ◽  
Vol 534 (3) ◽  
pp. 721-732 ◽  
Author(s):  
Marcella Rocchetti ◽  
Alessandra Besana ◽  
Georgina B. Gurrola ◽  
Lourival D. Possani ◽  
Antonio Zaza
Keyword(s):  
Guinea Pig ◽  
Action Potential ◽  
Delayed Rectifier ◽  
Rate Dependency ◽  
Ventricular Action Potential

Effect of simulated Ito on guinea pig and canine ventricular action potential morphology

2006 ◽  
Vol 291 (2) ◽  
pp. H631-H637 ◽  
Author(s):  
Min Dong ◽  
Xiaoyin Sun ◽  
Astrid A. Prinz ◽  
Hong-Sheng Wang
Keyword(s):  
Guinea Pig ◽  
Action Potential ◽  
Ventricular Myocytes ◽  
Phase 1 ◽  
Outward Current ◽  
Transient Outward Current ◽  
Ventricular Cells ◽  
Perforated Patch Clamp ◽  
Ventricular Action Potential

The transient outward current ( Ito) is a major repolarizing current in the heart. Marked reduction of Ito density occurs in heart failure and is accompanied by significant action potential duration (APD) prolongation. To understand the species-dependent role of Ito in regulating the ventricular action potential morphology and duration, we introduced simulated Ito conductance in guinea pig and canine endocardial ventricular myocytes using the dynamic clamp technique and perforated patch-clamp recordings. The effects of simulated Ito in both types of cells were complex and biphasic, separated by a clear density threshold of ∼40 pA/pF. Below this threshold, simulated Ito resulted in a distinct phase 1 notch and had little effect on or moderately prolonged the APD. Ito above the threshold resulted in all-or-none repolarization and precipitously reduced the APD. Qualitatively, these results agreed with our previous studies in canine ventricular cells using whole cell recordings. We conclude that 1) contrary to previous gene transfer studies involving the Kv4.3 current, the response of guinea pig ventricular myocytes to a fully inactivating Ito is similar to that of canine ventricular cells and 2) in animals such as dogs that have a broad cardiac action potential, Ito does not play a major role in setting the APD.

Opposite effects of halothane on guinea-pig ventricular action potential duration

2000 ◽  
Vol 390 (1-2) ◽  
pp. 95-101 ◽  
Author(s):  
Cécile Terrenoire ◽  
Vincent Piriou ◽  
Robert Bonvallet ◽  
Christophe Chouabe ◽  
Leon Espinosa ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Action Potential ◽  
Action Potential Duration ◽  
Ventricular Action Potential

Anion and cation modulation of the guinea-pig ventricular action potential during ?-adrenoceptor stimulation

1993 ◽  
Vol 424 (1) ◽  
pp. 54-62 ◽  
Author(s):  
P. C. Levesque ◽  
C. D. Clark ◽  
S. I. Zakarov ◽  
L. V. Rosenshtraukh ◽  
J. R. Hume
Keyword(s):  
Guinea Pig ◽  
Action Potential ◽  
Ventricular Action Potential
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