Dyslipidemias with desirable plasma total cholesterol levels and angiographically demonstrated coronary artery disease

1990 ◽  
Vol 65 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Michael Miller ◽  
Lucy A. Mead ◽  
Peter O. Kwiterovich ◽  
Thomas A. Pearson
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Total Cholesterol ◽  
Plasma Total Cholesterol ◽  
Cholesterol Levels ◽  
Artery Disease

Non-Attendance at Secondary Prevention Clinics: The Effect on Lipid Management

2005 ◽  
Vol 50 (2) ◽  
pp. 54-56 ◽  
Author(s):  
A L McLeod ◽  
L Brooks ◽  
V Taylor ◽  
A Wylie ◽  
P F Currie ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Secondary Prevention ◽  
Total Cholesterol ◽  
Outpatient Clinic ◽  
Lipid Profiles ◽  
Lipid Management ◽  
Cholesterol Levels ◽  
Artery Disease

Background: Secondary prevention of coronary artery disease is effective in reducing morbitiy and mortality. Our aim was to assess lipid management following non-attendance to a hospital based secondary prevention clinic Methods: Data were collected over 5 years on statin usage and total cholesterol levels for patients with coronary artery disease following attendance at a cardiac nurse led outpatient clinic. Lipid levels were taken from a central laboratory database, for both patients discharged from clinic and non-attenders. Results: From 935 inpatients discharged from hospital, 248 (29%) defaulted from outpatient follow up. Lipid lowering drug usage was similar (72% vs. 74% for non-attenders, p=NS). Attenders at the nurse led outpatient clinic were more likely to achieve a total cholesterol <5mmol/L at discharge than non-attenders (70% vs. 43%;p<0.001), with a lower mean total cholesterol (4.75 ± 0.06 mmol/L vs. 5.33±0.08 mmol/L; p<0.001). Non-attenders subsequently had a greater number of cholesterol measurements than those who were discharged from the hospital based clinic (range 0–12, c2 23.8 on 12df, p<0.05). Lipid profiles in hospital non-attenders remained inferior with fewer achieving a total cholesterol <5mmol/L (61% vs. 78%; p<0.001), and having greater mean total cholesterol levels (4.85 ± 0.06 mmol/L vs. 4.52 ± 0.05 mmol/L; p< 0.001). Conclusions: Patients defaulting from hospital follow up have higher total cholesterols with fewer at target level compared to attenders. Though non-attenders receive subsequent lipid measurement, inferior lipid profiles persist compared to patients who completed hospital follow up to be discharged. Further implementation strategies are needed with regard to lipid management in this patient group.

Association of remnant-like particle cholesterol with coronary artery disease in patients with normal total cholesterol levels

2000 ◽  
Vol 139 (2) ◽  
pp. 305-310 ◽  
Author(s):  
Hiroshi Masuoka ◽  
Shigeru Kamei ◽  
Hidetaka Wagayama ◽  
Morihiro Ozaki ◽  
Atsushi Kawasaki ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Total Cholesterol ◽  
Cholesterol Levels ◽  
Artery Disease

scholarly journals Clinical utility of brain-derived neurotrophic factor as a biomarker with left ventricular echocardiographic indices for potential diagnosis of coronary artery disease

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
K. G. Monisha ◽  
Paramasivam Prabu ◽  
M. Chokkalingam ◽  
Ram Murugesan ◽  
Dragan Milenkovic ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Total Cholesterol ◽  
Neurotrophic Factor ◽  
Left Ventricular ◽  
Healthy Controls ◽  
Two Dimensional ◽  
Bdnf Level ◽  
Artery Disease ◽  
Serum Bdnf

Abstract Brain-derived neurotrophic factor (BDNF) plays a central pivotal role in the development of the cardiovascular system. Recent evidence suggests that BDNF has adverse subclinical cardiac remodeling in participants with cardiovascular disease risk factors. Relating serum BDNF levels with two-dimensional echocardiographic indices will provide insights into the BDNF mediated pathophysiology in coronary artery disease (CAD) that may shed light upon potential diagnostic biomarkers. For the study, 221 participants were recruited and classified based on coronary angiogram examination as control (n = 105) and CAD (n = 116). All participants underwent routine blood investigation, two-dimensional echocardiography, and serum BDNF estimation. As a result, total cholesterol, triglyceride, low-density lipid, high-density lipid, HbA1c (glycosylated hemoglobin), serum creatinine, eosinophils, lymphocyte, monocytes, neutrophils, and platelets were significantly elevated in CAD individuals compared to controls. Notably, the serum BDNF was significantly lower in individuals with CAD (30.69 ± 5.45 ng/ml) than controls (46.58 ± 7.95 ng/ml). Multivariate regression analysis showed neutrophils, total cholesterol, left ventricular mass index, mitral inflow E/A ratio, and pulmonary vein AR duration were associated with low BDNF in CAD. Four independent support vector machine (SVM) models performed to ensure the BDNF level in the classification of CAD from healthy controls. Particularly, the model with serum BDNF concentration and blood parameters of CAD achieved significant improvement from 90.95 to 98.19% in detecting CAD from healthy controls. Overall, our analysis provides a significant molecular linkage between the serum BDNF level and cardiovascular function. Our results contribute to the emerging evidence of BDNF as a potential diagnostic value in CAD that might lead to clinical application.

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