Reversal of human platelet aggregation by low concentrations of nitroglycerin in vitro in normal subjects

1992 ◽  
Vol 70 (7) ◽  
pp. 802-806 ◽  
Author(s):  
Yuliy Y. Chirkov ◽  
Jurate I. Naujalis ◽  
Sylvia Barber ◽  
R.Edward Sage ◽  
David W. Gove ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Normal Subjects ◽  
Human Platelet Aggregation ◽  
Low Concentrations

Human Platelet Aggregation and Release Reaction Induced by Platelet Activating Factor (PAF-Acether) – Effects of Acetylsalicylic Acid and External Ionized Calcium

1985 ◽  
Vol 53 (02) ◽  
pp. 221-224 ◽  
Author(s):  
Marco Cattaneo ◽  
Maria Teresa Canciani ◽  
Pier Mannuccio Mannucci
Keyword(s):  
Platelet Aggregation ◽  
Acetylsalicylic Acid ◽  
Human Platelet ◽  
Platelet Rich Plasma ◽  
Normal Subjects ◽  
Human Platelet Aggregation ◽  
Low Concentrations ◽  
Before And After ◽  
Platelet Secretion

SummaryThe effects of the cyclo-oxygenase inhibition on PAF-acether- induced human platelet aggregation and secretion are controversial. We studied the above parameters on citrated platelet-rich plasma of 12 normal subjects before and after the in vivo administration of acetylsalicylic acid (ASA). Individual sensitivities to PAF-acether were highly variable. ASA completely inhibited the platelet secretion induced by low concentrations of PAF-acether, but caused only partial inhibition when platelets were exposed to high concentrations of PAF-acether. The concentration of PAF-acether which overcame the cyclo-oxygenase inhibition varied substantially, depending on the individual sensitivity of the platelets to it. The addition of CaCl2 2 mM to the samples did not affect the extent of the platelet secretion, but increased irreversible aggregation in samples taken both before and after the ASA administration. These data suggest that low concentrations of PAF-acether stimulate the human platelet secretion by activating the cyclo-oxygenase pathway, whereas higher concentrations also trigger other mechanism(s) that suffice to induce human platelet secretion and full aggregation.

In Vitro Assay of Quinoa (Chenopodium quinoa Willd.) and Lupin (Lupinus spp.) Extracts on Human Platelet Aggregation

2020 ◽  
Vol 75 (2) ◽  
pp. 215-222
Author(s):  
Marcelo Alarcón ◽  
Michelle Bustos ◽  
Diego Mendez ◽  
Eduardo Fuentes ◽  
Ivan Palomo ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Chenopodium Quinoa ◽  
In Vitro Assay ◽  
Vitro Assay ◽  
Human Platelet Aggregation

scholarly journals Inhaled Nitric Oxide Inhibits Human Platelet Aggregation, P-Selectin Expression, and Fibrinogen Binding In Vitro and In Vivo

Circulation ◽  
1998 ◽  
Vol 97 (15) ◽  
pp. 1481-1487 ◽  
Author(s):  
André Gries ◽  
Christoph Bode ◽  
Karlheinz Peter ◽  
Axel Herr ◽  
Hubert Böhrer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Platelet Aggregation ◽  
Human Platelet ◽  
Inhaled Nitric Oxide ◽  
Human Platelet Aggregation ◽  
Fibrinogen Binding

In vitro and ex vivo effect of cimetidine on human platelet aggregation

1986 ◽  
Vol 42 (1) ◽  
pp. 113-114
Author(s):  
B. Gachályi ◽  
K. Tihanyi ◽  
Á. Vas ◽  
B. Nádas ◽  
A. Káldor
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Ex Vivo ◽  
Human Platelet Aggregation

In vitro enhancement of human platelet aggregation by somatostatin

1988 ◽  
Vol 44 (10) ◽  
pp. 892-894 ◽  
Author(s):  
P. P. Gazzaniga ◽  
G. Di Macco ◽  
R. La Mancusa ◽  
A. Oddi ◽  
G. Pappalardo ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Human Platelet Aggregation

Dehydroepiandrosterone Inhibits Human Platelet Aggregation in Vitro and in Vivoa

2006 ◽  
Vol 774 (1) ◽  
pp. 281-290 ◽  
Author(s):  
ROBERT L. JESSE ◽  
KATHY LOESSER ◽  
DAVID M. EICH ◽  
YONG ZHEN QIAN ◽  
MICHAEL L. HESS ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Human Platelet Aggregation

Low concentrations of reactive γ-ketoaldehydes prime thromboxane-dependent human platelet aggregation via p38-MAPK activation

2009 ◽  
Vol 1791 (4) ◽  
pp. 307-313 ◽  
Author(s):  
Nathalie Bernoud-Hubac ◽  
Denise Al Alam ◽  
Jennifer Lefils ◽  
Sean S. Davies ◽  
Venkataraman Amarnath ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
P38 Mapk ◽  
Human Platelet ◽  
Mapk Activation ◽  
Human Platelet Aggregation ◽  
Low Concentrations

2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) attenuates human platelet aggregation, secretion and spreading in vitro

2014 ◽  
Vol 133 (2) ◽  
pp. 211-217 ◽  
Author(s):  
Ke Xiang ◽  
Gang Liu ◽  
Ya-Jun Zhou ◽  
Hong-Zhen Hao ◽  
Zhao Yin ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Human Platelet Aggregation

Effect of Armagnac fractions on human platelet aggregation in vitro and on rat arteriovenous shunt thrombosis in vivo probably not related only to polyphenols

2007 ◽  
Vol 119 (4) ◽  
pp. 407-413 ◽  
Author(s):  
Najim A. Al Awwadi ◽  
Anne Borrot-Bouttefroy ◽  
Anwar Umar ◽  
Cédric Saucier ◽  
Marie-Claude Segur ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Arteriovenous Shunt ◽  
Shunt Thrombosis ◽  
Human Platelet Aggregation
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