Induction of polycystic ovarian disease in rats by continuous light. IV. Effect of a bovine pineal gland extract

1969 ◽  
Vol 105 (2) ◽  
pp. 274-275 ◽  
Author(s):  
Krishna B. Singh
Keyword(s):  
Pineal Gland ◽  
Continuous Light ◽  
Polycystic Ovarian Disease ◽  
Ovarian Disease ◽  
Gland Extract ◽  
Bovine Pineal Gland

INHIBITION OF OVULATION INDUCED WITH PMSG AND HCG IN PREPUBERAL MICE BY BOVINE PINEAL GLAND EXTRACTS OF DIFFERENT MOLECULAR WEIGHTS

1979 ◽  
Vol 59 (2) ◽  
pp. 375-380
Author(s):  
MARTIN T. SØRENSEN ◽  
R. R. HACKER
Keyword(s):  
Molecular Weight ◽  
Body Weight ◽  
Pineal Gland ◽  
Detrimental Effect ◽  
Inhibitory Effect ◽  
Positive Linear Relationship ◽  
Molecular Weights ◽  
Gland Extract ◽  
Different Molecular Weight ◽  
Bovine Pineal Gland

Bovine pineal gland extract was separated into fractions of different molecular weight via successive ultrafiltrations. The 1000–10 000 dalton fraction was purified by column chromatography yielding fractions A and B. The pineal fractions were tested for their ability to inhibit ovulation induced by PMSG and HCG in prepuberal mice. Administration of pineal fractions of molecular weights below 500 daltons, 500–1000 daltons, and fraction A (1000–10 000 daltons) suppressed the number of ovulations per mouse (P < 0.01). The 10 000–100 000 dalton fraction was the least potent (P < 0.10) of the inhibitory fractions and fraction B (1000–10 000 daltons) did not exhibit any inhibitory effect (P > 0.10). There was a positive linear relationship (P < 0.025) between the molecular weight of the inhibitory fractions administered and the proportion of mice that ovulated. All pineal extract fractions had a detrimental effect on body weight.

THE PRESENCE OF A »GONADOTROPHIN INHIBITING SUBSTANCE« IN PINEAL GLAND EXTRACTS

1965 ◽  
Vol 48 (4) ◽  
pp. 561-564 ◽  
Author(s):  
Louis J. Soffer ◽  
Marvin Fogel ◽  
Amiel Z. Rudavsky
Keyword(s):  
Pineal Gland ◽  
Inhibitory Activity ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Uterine Weight ◽  
Gland Extract ◽  
Human Menopausal Gonadotrophin ◽  
Bovine Pineal Gland

ABSTRACT A bovine pineal gland extract was found to inhibit the stimulatory effect of both human chorionic gonadotrophin (HCG) and human menopausal gonadotrophin (HMG) on mouse uterine weight, while melatonin displayed no such inhibitory activity. The pineal gland extract did not inhibit the stimulatory effect of oestrone.

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