Pregnancy and nephrotic syndrome due to renal amyloidosis

An interesting and unusual case of an 11-year-old white male with chronically infected burns of his lower extremities who developed amyloidosis and the nephrotic syndrome is reported. The case is considered from the following aspects: (1) the rarity of amyloidosis in burns, (2) the short duration between the onset of the primary disease and the amyloidosis, (3) the age of the patient, and (4) the striking clinical improvement of the renal manifestations after the treatment of the burn. The treatment of the burns, using homografts, and the importance of renal biopsy in the diagnosis and follow-up are also discussed. Addendum: A third renal biopsy was performed in August, 1963, about one year following the second one. The amount of amyloid seen in the glomeruli did not seem to have diminished.

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Remission of the Nephrotic Syndrome in Renal Amyloidosis

New England Journal of Medicine ◽

10.1056/nejm197001152820304 ◽

1970 ◽

Vol 282 (3) ◽

pp. 128-132 ◽

Cited By ~ 87

Author(s):

J. Lowenstein ◽

G. Gallo

Keyword(s):

Nephrotic Syndrome ◽

Renal Amyloidosis

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139 Renal Ablation Using Ureteral Ligation in Nephrotic Syndrome Due to Renal Amyloidosis

American Journal of Kidney Diseases ◽

10.1053/j.ajkd.2011.02.142 ◽

2011 ◽

Vol 57 (4) ◽

pp. B51

Author(s):

Mira T. Keddis ◽

Stephen C. Textor

Keyword(s):

Nephrotic Syndrome ◽

Renal Amyloidosis ◽

Renal Ablation

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Nephrotic syndrome

10.1093/med/9780199568741.003.0161 ◽

2018 ◽

Author(s):

William G. Herrington ◽

Aron Chakera ◽

Christopher A. O’Callaghan

Keyword(s):

Nephrotic Syndrome ◽

Diabetic Nephropathy ◽

Membranous Nephropathy ◽

Clinical Syndrome ◽

Minimal Change ◽

Renal Amyloidosis ◽

Creatinine Ratio ◽

Heavy Proteinuria ◽

Nephrotic Range Proteinuria ◽

Secondary Causes

Nephrotic syndrome is a clinical syndrome of heavy proteinuria (greater than 3.5 g per 24 hours), oedema, and hypoalbuminaemia, which is associated with hyperlipidaemia and a procoagulant state. Causes of nephrotic syndrome are traditionally classified by their histopathological descriptions. In most cases, the histological picture can have a primary (idiopathic) or secondary cause. Minimal change, membranous nephropathy, and focal segmental glomerulosclerosis account for over 60% of cases. Diabetic nephropathy and renal amyloidosis are common secondary causes of nephrotic syndrome. Nephrotic-range proteinuria will show up as at least 3+ protein on urinalysis. The diagnosis is confirmed by a urinary protein-to-creatinine ratio over 300 mg/mmol, and hypalbuminaemia. In adults, renal biopsy is the diagnostic test. This chapter addresses the causes, diagnosis, and management of nephrotic syndrome in adults.

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