Management of Increased Intraocular Pressure After Cataract Extraction

Objective: To assess incidence and risk factors of cataract extraction in patients with primary congenital glaucoma, surgical outcome, and complications. Material and method: Retrospective cohort study, in which 108 patients with primary congenital glaucoma were included. Data collected were need for cataract extraction and at what age, intraocular pressure at diagnosis of primary congenital glaucoma, required antiglaucomatous surgeries, possible mutation in the CYP1B1 gene, and final visual acuity. Among the patients who required cataract extraction were visual acuity, intraocular pressure, and complications, evaluated preoperatively and postoperatively. The data were analysed with STATA. Results: A total of 198 eyes of 108 patients were included, with a median follow-up of 8 years (range: 5–53). In all, 32 eyes (16.2%) of 24 patients (22%) required cataract extraction. The median age for cataract extraction was 12.94 years (interquartile range: 2.42–22). The main identified risk factors associated with cataract extraction were antiglaucomatous surgeries (hazard ratio 1.48, p < 0.001) and valvular implant (hazard ratio 2.78, p < 0.001). Lens was implanted in 30/32 eyes and the main complications were intraocular pressure decontrol ( n = 13), capsular fibrosis ( n = 7), corneal decompensation ( n = 4), lens subluxation ( n = 4), and endophthalmitis ( n = 1). Visual acuity improvement was observed after cataract extraction in 66.67% of eyes. Conclusions: There is a high incidence of cataract surgery in patients with primary congenital glaucoma, but generally outside of pediatric age. A greater risk of cataract extraction was identified in those patients with a greater number of antiglaucomatous surgeries, especially after valvular implantation. Despite the high rate of complications related to cataract extraction in primary congenital glaucoma, good visual improvement was observed after surgery.

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One-year results of gonioscopy-assisted transluminal trabeculotomy: Evaluation of prognostic factors

European Journal of Ophthalmology ◽

10.1177/1120672120908716 ◽

2020 ◽

pp. 112067212090871 ◽

Cited By ~ 2

Author(s):

Mehmet Ozgur Cubuk ◽

Erkan Unsal

Keyword(s):

Intraocular Pressure ◽

Success Rate ◽

Open Angle Glaucoma ◽

Multivariate Logistic Regression Analysis ◽

Cataract Extraction ◽

Glaucoma Surgery ◽

Open Angle ◽

Multivariate Logistic Regression ◽

Surgical Success ◽

Corrected Visual Acuity

Purpose: To present the results and complications of gonioscopy-assisted transluminal trabeculotomy in adults with open-angle glaucoma using our different approaches during and after surgery. Method: A retrospective comparative study was designed. Patients with regular 12-month follow-up history were included. Two groups were defined: group 1 comprised patients with open-angle glaucoma who underwent gonioscopy-assisted transluminal trabeculotomy surgery alone; group 2 included patients with open-angle glaucoma who underwent combined gonioscopy-assisted transluminal trabeculotomy and cataract extraction. A 30% reduction in preoperative intraocular pressure or postoperative intraocular pressure below 18 mm Hg was considered as surgical success. The success rate, alteration in intraocular pressure, alteration in best-corrected visual acuity, alteration in the need for antiglaucomatous medications, surgical complications, and the need for additional glaucoma surgery were evaluated and compared between the groups. Multivariate logistic regression analysis was used to show the association between the surgical success and possible prognostic factors. Results: A total of 37 eyes fulfilled the inclusion criteria and were analyzed in this study. An overall mean decrease in intraocular pressure of 11.3 ± 9.3 mm Hg was shown at 12 months (p < 0.001). The medication-free surgical success rate was 37.8% (14/37), and the surgical success rate with medication was 91.8% (33/37) at 12 months. Surgical outcomes were similar between patients who underwent gonioscopy-assisted transluminal trabeculotomy alone and those who had combined gonioscopy-assisted transluminal trabeculotomy and cataract extraction (p > 0.05). The most common postoperative complication was hyphemia (89.1%). There were no complications that threatened best-corrected visual acuity. Multivariate logistic regression analysis revealed one significant association between the presence of blood in Schlemm’s canal and surgical success (odds ratio = 1.47; 95% confidence interval = 1.25–1.68; p = 0.047). Conclusion: This study showed that the gonioscopy-assisted transluminal trabeculotomy procedure is an effective and minimally invasive form of glaucoma surgery. Its effect was related to intraoperative blood in Schlemm’s canal.

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Comparing iStent versus CyPass with or without phacoemulsification in patients with glaucoma: a meta-analysis

Therapeutic Advances in Chronic Disease ◽

10.1177/2040622318820850 ◽

2019 ◽

Vol 10 ◽

pp. 204062231882085 ◽

Cited By ~ 1

Author(s):

Ali Mahdavi Fard ◽

Sangita P. Patel ◽

Leili Pourafkari ◽

Nader D. Nader

Keyword(s):

Intraocular Pressure ◽

Meta Analysis ◽

Cochrane Review ◽

Cataract Extraction ◽

Lowering Effect ◽

The Mean ◽

Mean Differences ◽

Review Manager

Bacground: The aim of this study was to conduct a meta-analysis to compare the overall intraocular pressure (IOP)-lowering effect of iStent or CyPass as isolated procedures or in combination with cataract extraction. Materials and methods: Cochrane review manager 5.3 software (RevMan® 5.3) was used for a meta-analysis of IOPs and the number of antiglaucoma medications in six groups according to the type and number of stents and whether the procedure was isolated or in combination with cataract extraction. Main results: A total of 33 out of 446 publications retrieved have been enrolled. The mean changes in IOP in the groups with one iStent and more than two iStents with concurrent cataract extraction were −3.78 ± 0.53 mmHg and −3.89 ± 0.73 mmHg, respectively. The mean differences in IOP in the groups with one iStent and more than two iStents without concurrent cataract extraction were −3.96 ± 0.25 mmHg and −7.48 ± 0.55 mmHg, respectively. The mean changes in IOP in the groups with CyPass implantation with and without concurrent cataract extraction were −4.97 ± 1.38 mmHg and −8.96 ± 0.16 mmHg, respectively. Conclusions: Both iStent and CyPass either in combination with cataract extraction or as isolated procedures effectively decrease IOP. This effect is greatest with isolated implantation of CyPass followed by multiple iStents and then single iStent implantation and lasts up to 2 years.

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Effects of 0.5% and 0.25% Apraclonidine on Postoperative Intraocular Hypertension after Cataract Extraction

European Journal of Ophthalmology ◽

10.1177/112067219800800203 ◽

1998 ◽

Vol 8 (2) ◽

pp. 67-70 ◽

Cited By ~ 3

Author(s):

S. Simsek ◽

A. Demirok ◽

T. Yasar ◽

A. Çinal ◽

A. Bayram ◽

...

Keyword(s):

Intraocular Pressure ◽

Side Effects ◽

Prospective Study ◽

Cataract Extraction ◽

Control Group ◽

Extracapsular Cataract Extraction ◽

Artificial Tears ◽

Iol Implantation ◽

The Third ◽

Applanation Tonometer

Purpose We conducted a double-masked, prospective study to evaluate the effect of 0.5% and 0.25% apraclonidine on postoperative intraocular pressure (IOP) in patients undergoing extracapsular cataract extraction (ECCE) with intraocular lens (IOL) implantation. Methods Fifty-four patients scheduled for ECCE were randomly divided into three groups of 18. The first group received one drop of 0.50% apraclonidine topically one hour before surgery and immediately after the end of the procedure. The second group received the same regimen but with 0.25% apraclonidine. The third group received artificial tears as the control group. IOP was measured 12 h preoperatively and 6 and 24 h postoperatively. All the measurements were made using the same Goldmann applanation tonometer by the same surgeon who did not know to which group the patient belonged. Results Preoperative mean IOP was 13.66 ± 2.76 mmHg in the first group, 14.27 ± 2.24 mmHg in the second and 14.5 ± 1.34 mmHg in the control group. The differences were not significant (p=0.398). Mean IOP at the early postoperative visit (6 h) was significantly lower in the first group (17.44 ± 4.95 mmHg) than the second (21.78 ± 7.19 mmHg) and the control group (24.55 ± 5.65 mmHg) (p<0.001). Mean postoperative IOP at 24 h was again significantly lower in the first group (14.33 ± 3.75 mmHg) than the second (17.11 ± 4.16 mmHg) and the control group (19.61 ± 3.20 mmHg) (p<0.001). Conclusions Our findings indicate that topical 0.5% apraclonidine controlled early postoperative intraocular hypertension after cataract extraction without any side effects, while the 0.25% drops were not effective.

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