Semisynthetic synthesis and biological activity of a Clostridial-type ferredoxin free of aromatic amino acid residues

1974 ◽  
Vol 61 (1) ◽  
pp. 163-169 ◽  
Author(s):  
Eglis T. Lode ◽  
Cheryl L. Murray ◽  
Jesse C. Rabinowitz
Keyword(s):  
Biological Activity ◽  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Amino Acid Residues

Configurational requirements of aromatic amino acid residues for the activity of PRP-hexapeptide

1988 ◽  
Vol 53 (11) ◽  
pp. 2583-2590 ◽  
Author(s):  
Aleksandra Kubik ◽  
Zbigniew Szewczuk ◽  
Ignacy Z. Siemion ◽  
Zbigniew Wieczorek ◽  
Krystyna Spiegel ◽  
...  
Keyword(s):  
Immune Response ◽  
Biological Activity ◽  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Amino Acid Residues ◽  
Aromatic Rings

The three analogues with D-amino acid substituents at position 1 and 5 of PRP-hexapeptide were synthesized and tested for its biological activity to check the influence of the spacial orientation of aromatic rings on the immune response. One of the analogs (Tyr-Val-Pro-Leu-D-Phe-Pro) was found to have the immunoregulatory activity.

Biological Function and Chemistry of Endothelin. A Review

1999 ◽  
Vol 64 (8) ◽  
pp. 1211-1252 ◽  
Author(s):  
Jan Hlaváček ◽  
Renáta Marcová
Keyword(s):  
Biological Activity ◽  
Amino Acid ◽  
Biological Function ◽  
Biological Properties ◽  
Structural Basis ◽  
Amino Acid Residues ◽  
Snake Venoms ◽  
Vasoactive Peptides ◽  
Physico Chemical ◽  
Endothelin A

The first part of this review deals with the biosynthesis and a biological function of strongly vasoactive peptides named endothelins (ETs) including vasoactive intestinal contractor. Where it was useful, snake venoms sarafotoxins which are structural endothelin derivatives, were also mentioned. In the second part, an attention is paid to structural basis of the ETs biological activity, with respect to alterations of amino acid residues in the parent peptides modifying the conformation and consequently the physico-chemical and biological properties in corresponding ETs analogs. Special attention is focussed on the area of ETs receptors and their interaction with peptide and non peptide agonists and antagonists, important in designing selective inhibitors of ETs receptors potentially applicable as drugs in a medicine. A review with 182 references.

“In vivo” amplification of biological activity of tetragastrin by amino acid hydroxamates

1984 ◽  
Vol 4 (12) ◽  
pp. 1009-1015 ◽  
Author(s):  
J. P. Bali ◽  
H. Mattras ◽  
A. Previero ◽  
M. A. Coletti-Previero
Keyword(s):  
Biological Activity ◽  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Aminopeptidase Activity ◽  
Proteolytic Degradation ◽  
Short Peptides ◽  
Rat Blood ◽  
Active Peptides

Rat blood was shown to contain an aminopeptidase which rapidly hydrolyses short peptides containing an aromatic amino acid as N-terminal residue. Using tetragastrin (Trp-Met-Asp-PheNH 2) as substrate, we showed that some amino acid hydroxamates inhibit rat aminopeptidase activity ‘in vitro’ in the following order: HTrpNHOH > HPheNHOH ≫ HAIaNHOH. The same hydroxamates markedly enhanced the biological activity of tetragastrin ‘in vivo’. The amplification of the secretory effect, correlated with the amount of the hydroxamate used, strongly suggests that these compounds can stabilize a number of active peptides in vivo by inhibiting their proteolytic degradation.

Metal complexes of polymers with amino acid residues. formation, stability and controlled biological activity

1990 ◽  
Vol 14 (1) ◽  
pp. 61-70 ◽  
Author(s):  
V.A. Lee ◽  
R.I. Musin ◽  
R.I. Tashmukhamedov ◽  
M.I. Shtilman ◽  
S.Sh. Rashidova
Keyword(s):  
Biological Activity ◽  
Amino Acid ◽  
Metal Complexes ◽  
Amino Acid Residues

Reductant‐Induced Free Radical Fluoroalkylation of Nitrogen Heterocycles and Innate Aromatic Amino Acid Residues in Peptides and Proteins

2019 ◽  
Vol 25 (69) ◽  
pp. 15779-15785 ◽  
Author(s):  
Kheironnesae Rahimidashaghoul ◽  
Iveta Klimánková ◽  
Martin Hubálek ◽  
Michal Korecký ◽  
Matúš Chvojka ◽  
...  
Keyword(s):  
Free Radical ◽  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Nitrogen Heterocycles ◽  
Amino Acid Residues

Fibrous Aggregates of Short Peptides Containing Two Distinct Aromatic Amino Acid Residues

2019 ◽  
Vol 16 (11) ◽  
Author(s):  
Wojciech Lipinski ◽  
Joanna Wasko ◽  
Malgorzata Walczak ◽  
Justyna Fraczyk ◽  
Zbigniew J. Kaminski ◽  
...  
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Short Peptides ◽  
Amino Acid Residues

Conformations and Orientations of Aromatic Amino Acid Residues of Tachyplesin I in Phospholipid Membranes†

Biochemistry ◽  
1997 ◽  
Vol 36 (14) ◽  
pp. 4352-4359 ◽  
Author(s):  
Osamu Oishi ◽  
Shoji Yamashita ◽  
Etsuko Nishimoto ◽  
Sannamu Lee ◽  
Gohsuke Sugihara ◽  
...  
Keyword(s):  
Amino Acid ◽  
Aromatic Amino Acid ◽  
Phospholipid Membranes ◽  
Amino Acid Residues ◽  
Tachyplesin I
Sign in / Sign up

Export Citation Format

Share Document