The hydrolysis product of ICRF-187 promotes iron-catalysed hydroxyl radical production via the Fenton reaction

1993 ◽  
Vol 45 (10) ◽  
pp. 1967-1972 ◽  
Author(s):  
Carin Thomas ◽  
Glenn F. Vile ◽  
Christine C. Winterbourn
Keyword(s):  
Hydroxyl Radical ◽  
Fenton Reaction ◽  
Hydrolysis Product ◽  
Radical Production

Fenton chemistry in biology and medicine

2007 ◽  
Vol 79 (12) ◽  
pp. 2325-2338 ◽  
Author(s):  
Josef Prousek
Keyword(s):  
Hydroxyl Radical ◽  
Fenton Reaction ◽  
Brown Rot ◽  
White Rot ◽  
Practical Utilization ◽  
Fenton Chemistry ◽  
Radical Production

Various aspects of the participation of Fenton chemistry in biology and medicine are reviewed. Accumulated evidence shows that both hydroxyl radical and ferryl [Fe(IV)=O]2+ can be formed under a variety of Fenton and Fenton-like reactions. Some examples of metal-independent hydroxyl radical production are included. Extracellular Fenton reaction is illustrated by the white rot and brown rot wood-decaying fungi. The natural and practical utilization of catechol-driven Fenton reaction is also presented.

scholarly journals Fe-EDTA-Bisamide and Fe-ADR-925, The Iron-Bound Hydrolysis Product of the Cardioprotective Agent Dexrazoxane, Cleave DNA Via the Hydroxyl Radical

1997 ◽  
Vol 4 (4) ◽  
pp. 199-205 ◽  
Author(s):  
Thomas J. Magliery ◽  
Lizabeth K. Vitellaro ◽  
Ndeye Khady Diop ◽  
Rosemary A. Marusak
Keyword(s):  
Side Effects ◽  
Hydroxyl Radical ◽  
Plasmid Dna ◽  
Dna Cleavage ◽  
Antitumor Agents ◽  
Hydrolysis Product ◽  
Solution Chemistry ◽  
Radical Scavenger ◽  
Radical Production ◽  
Radical Generation

Use of the antitumor drug doxorubicin is limited by cardiomyopathic side-effects which are believed to be due to iron-mediated hydroxyl radical generation. Dexrazoxane reduces this cardiotoxicity, possibly by removal of iron from doxorubicin by the EDTA-like hydrolysis product of dexrazoxane, ADR-925. However, EDTA-diimides like dexrazoxane, previously used as antitumor agents, are themselves carcinogenic, and recent studies have found that Fe-ADR-925 can also promote hydroxyl radical production. This study demonstrates that, like Fe-EDTA, Fe-ADR-925 and a related desmethyl complex can cleave plasmid DNA under Fenton conditions, and suggests by radical scavenger study that this cleavage is probably via the hydroxyl radical. Differences in DNA cleavage dependence upon concentrations of Fe-EDTA, Fe-ADR-925 and Fe-EDTA-bisamide can be explained by differences in the solution chemistry of the complexes.

Hydroxyl radical production by a heterogeneous Fenton reaction supported in insoluble tannin from bark of Pinus radiata

2016 ◽  
Vol 24 (7) ◽  
pp. 6135-6142 ◽  
Author(s):  
Romina Romero ◽  
David Contreras ◽  
Cristina Segura ◽  
Brigitte Schwederski ◽  
Wolfgang Kaim
Keyword(s):  
Hydroxyl Radical ◽  
Pinus Radiata ◽  
Fenton Reaction ◽  
Heterogeneous Fenton ◽  
Radical Production ◽  
Heterogeneous Fenton Reaction

Quinolinic acid — Iron(II) complexes: Slow autoxidation, but enhanced hydroxyl radical production in the Fenton reaction

2001 ◽  
Vol 34 (5) ◽  
pp. 445-459 ◽  
Author(s):  
Jan Pláteník ◽  
Pavel Stopka ◽  
Martin Vejražka ◽  
Stanislav Štípek
Keyword(s):  
Hydroxyl Radical ◽  
Quinolinic Acid ◽  
Fenton Reaction ◽  
Radical Production
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