scholarly journals Synthesis and in vitro binding of N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides for the peripheral benzodiazepine binding sites

2006 ◽  
Vol 14 (11) ◽  
pp. 3938-3946 ◽  
Author(s):  
Taryn P. Homes ◽  
Filomena Mattner ◽  
Paul A. Keller ◽  
Andrew Katsifis
Keyword(s):  
Binding Sites ◽  
In Vitro Binding ◽  
Vitro Binding ◽  
Benzodiazepine Binding ◽  
Benzodiazepine Binding Sites

Anticonvulsant and anxiolytic-like effects of compounds isolated from Polygala sabulosa (Polygalaceae) in rodents: in vitro and in vivo interactions with benzodiazepine binding sites

2007 ◽  
Vol 197 (3) ◽  
pp. 351-360 ◽  
Author(s):  
Filipe Silveira Duarte ◽  
Mariel Marder ◽  
Alexandre Ademar Hoeller ◽  
Marcelo Duzzioni ◽  
Beatriz Garcia Mendes ◽  
...  
Keyword(s):  
Binding Sites ◽  
Benzodiazepine Binding ◽  
Benzodiazepine Binding Sites

scholarly journals The interaction of substituted benzamides with brain benzodiazepine binding sites in vitro

1988 ◽  
Vol 94 (4) ◽  
pp. 1234-1240 ◽  
Author(s):  
Roger W. Horton ◽  
Sandra Lowther ◽  
Jane Chivers ◽  
Peter Jenner ◽  
C. David Marsden ◽  
...  
Keyword(s):  
Binding Sites ◽  
Benzodiazepine Binding ◽  
Substituted Benzamides ◽  
Benzodiazepine Binding Sites

Muscarinic regulation of phospholipase A2 and iodide fluxes in FRTL-5 thyroid cells

1991 ◽  
Vol 125 (2) ◽  
pp. 192-200 ◽  
Author(s):  
Maria Di Girolamo ◽  
Daniela D'Arcangelo ◽  
Cinzia Bizzarri ◽  
Daniela Corda
Keyword(s):  
Arachidonic Acid ◽  
Adenylyl Cyclase ◽  
Muscarinic Receptor ◽  
Binding Sites ◽  
Signal Pathways ◽  
Thyroid Cells ◽  
In Vitro Binding ◽  
Vitro Binding ◽  
Stimulation Of

Abstract. FRTL-5 thyroid cells express a muscarinic receptor which inhibits the phospholipase C activity in a pirenzepine-insensitive manner. We here report that the cholinergic agonist carbachol decreases in these cells the steady-state iodide content, an effect correlated with the iodination of thyroglobulin and with thyroid hormone formation. Several signal pathways may be involved in this phenomenon since carbachol in addition to inhibiting phospholipase C, increased the arachidonic acid release and modified the adenylyl cyclase activity. In FRTL-5 cells, arachidonic acid is released via the direct stimulation of phospholipase A2 by a pirenzepine-sensitive muscarinic receptor coupled to a GTP binding protein sensitive to pertussis toxin. Regarding adenylyl cyclase, carbachol potentiated the thyrotropin-induced stimulation of the enzyme, whereas it did not affect the basal levels of cAMP. In vitro binding studies revealed the presence of two muscarinic binding sites. To summarize, the analysis of signal pathways and of in vitro binding sites indicates a complex muscarinic regulation of thyroid function, which includes the modulation of iodide fluxes.

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