The action of pyrethroids on sodium channels in myelinated nerve fibres and spinal ganglion cells of the frog

SynopsisThin sections of the spinal ganglion of the rat were cut and examined with the electron microscope. Two main types of nerve cell are described. Type A with equal electron density of nucleus and cytoplasm. The cytoplasm contains large aggregates of Nissl's substance discretely scattered throughout the cell, mitochondria and osmophilic granules. Type B with a “light” nucleus and a “dark” cytoplasm. The cytoplasm is closely packed and homogeneous so that it is difficult to separate out the various cytoplasmic elements.There is a well-marked nuclear membrane about 500 Å thick and characteristic strawberry nucleolus.The capsular cells are closely applied to the nerve cell with no intervening boundaries. A system of cytoplasmic filaments—the “endoplasmic reticulum”—is present in the intercellular regions.There are nerve fibres with lamellated myelin sheath, axolemma, Schwann cells and Schwann membrane.

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Difference in phosphorylation of neurofilament proteins in motor neurons and spinal ganglion cells

Neurochemistry International ◽

10.1016/0197-0186(89)90165-4 ◽

1989 ◽

Vol 15 (4) ◽

pp. 467-473 ◽

Cited By ~ 2

Author(s):

I TOYOSHIMA ◽

A YAMAMOTO ◽

O MASAMUNE ◽

S YAMADA ◽

M SATAKE

Keyword(s):

Motor Neurons ◽

Ganglion Cells ◽

Spinal Ganglion ◽

Neurofilament Proteins ◽

Spinal Ganglion Cells

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Structure of the Golgi apparatus of spinal ganglion cells as shown by the application of desilvering methods to standard Da Fano preparations

Journal of Morphology ◽

10.1002/jmor.1050900202 ◽

1952 ◽

Vol 90 (2) ◽

pp. 201-215 ◽

Cited By ~ 8

Author(s):

F. B. Adamstone

Keyword(s):

Golgi Apparatus ◽

Ganglion Cells ◽

Spinal Ganglion ◽

Spinal Ganglion Cells

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Changes in Nuclear DNA Molecular Pattern of Spinal Ganglion Cells during Regeneration of Spinal Nerves of the Cat

Proteins and Nucleic Acids ◽

10.1016/b978-0-12-281401-3.50021-4 ◽

1973 ◽

pp. 303-337

Author(s):

Isidore Gersh ◽

Peter J. Hand

Keyword(s):

Nuclear Dna ◽

Ganglion Cells ◽

Spinal Ganglion ◽

Spinal Nerves ◽

Molecular Pattern ◽

Spinal Ganglion Cells

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Electron Microscopic Observations on Spinal Ganglion Cells of Rana pipiens after Injection of Malononitrile

The Journal of Cell Biology ◽

10.1083/jcb.4.1.83 ◽

1958 ◽

Vol 4 (1) ◽

pp. 83-86 ◽

Cited By ~ 22

Author(s):

Everett Anderson ◽

V. L. van Breemen

Keyword(s):

Golgi Complex ◽

Rana Pipiens ◽

Ganglion Cells ◽

Morphological Changes ◽

Membrane System ◽

Spinal Ganglion ◽

Electron Microscopic ◽

Biochemical Alterations ◽

Spinal Ganglion Cells ◽

Electron Microscopes

Spinal ganglionic cells of Rana pipiens were studied with light and electron microscopes in normal animals and in animals which had received graded dosages of malononitrile intraperitoneally. After treatment no increase in the intensity of staining was noted in the Nissl substance when spinal ganglion cells were examined with the light microscope. The electron micrographs demonstrated the following in malononitrile-treated animals: 1. The cisternae of the endoplasmic reticulum composing the Nissl bodies appeared to fragment and lose their parallel orientation. 2. The microvesicular components of the Golgi complex appeared to increase in number, and the increase was apparently due to fragmentation of the membrane system of the Golgi complex. 3. The mitochondria enlarged and became pleomorphic, but displayed no alterations of internal structure. The morphological changes may be interpreted as reflections of biochemical alterations.

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