Effect of chrysotile asbestos on cytochrome P-450-dependent monooxygenase and glutathione-S-transferase activities in rat lung

1990 ◽  
Vol 75 (3) ◽  
pp. 305-313 ◽  
Author(s):  
Qamar Rahman ◽  
Sikandar G. Khan ◽  
Shahid Ali
Keyword(s):  
Chrysotile Asbestos ◽  
Rat Lung ◽  
Glutathione S Transferase ◽  
Cytochrome P 450

Rat lung and liver microsomal cytochrome P-450 isozymes involved in the hydroxylation of n-hexane

1986 ◽  
Vol 35 (21) ◽  
pp. 3733-3738 ◽  
Author(s):  
Rune Toftgård ◽  
Tapio Haaparanta ◽  
Lars Eng ◽  
James Halpert
Keyword(s):  
Rat Lung ◽  
Microsomal Cytochrome ◽  
Cytochrome P 450

Aniline and hexobarbital hydroxylases from rat lung and kidney: neither sex dependent nor inducible with phenobarbital

1982 ◽  
Vol 60 (10) ◽  
pp. 1247-1250 ◽  
Author(s):  
Janet L. Lister ◽  
Bruce B. Virgo
Keyword(s):  
Microsomal Protein ◽  
Female Rats ◽  
Rat Lung ◽  
Male And Female ◽  
Aniline Hydroxylase ◽  
Protein Levels ◽  
Male And Female Rats ◽  
Males And Females ◽  
Cytochrome P 450 ◽  
Lung And Kidney

The basal activities of aniline hydroxylase (AH), hexobarbital hydroxylase (HH), and ethylmorphine N-demethylase (ED) were measured in the 9000 × g supernatant of kidneys and lungs from male and female rats. No ED activity was detected in any tissue although all tissues N-demethylated three other substrates. The activities of AH and HH were not sex dependent in either kidney or lung. Similarly, pulmonary and renal microsomal protein concentrations were independent of sex. In addition, cytochrome P-450 levels in the kidney were the same in males and females (pulmonary P-450 was not measured). The pulmonary hydroxylases were more active than the renal enzymes in both sexes. In males, phenobarbital (ip, 50 rng∙kg−1∙day−1 for 3 days) failed to induce AH or HH in either kidney or lung; it did not increase the weight or microsomal protein levels of these organs and it also failed to increase renal P-450. Thus, the basal activities of AH and HH in lungs and kidneys are not different in male and female rats and are not increased by phenobarbital.

Effect of Chronic Exposure to Ozone and Nitric Acid on Cytochrome P-450 Monooxygenase System of Rat Lung and Liver

1996 ◽  
Vol 8 (7) ◽  
pp. 695-708 ◽  
Author(s):  
Ram K. Sindhu ◽  
William J. Mautz ◽  
Ichiro Fujita ◽  
Nai-San Wang ◽  
Yutaka Kikkawa
Keyword(s):  
Nitric Acid ◽  
Chronic Exposure ◽  
Monooxygenase System ◽  
Rat Lung ◽  
Cytochrome P 450

Responses of cytochrome P-450 isozymes of rat lung to in vivo exposure to ozone

1990 ◽  
Vol 54 (2-3) ◽  
pp. 327-335 ◽  
Author(s):  
Takahashi Yuji ◽  
Miura Takashi
Keyword(s):  
Rat Lung ◽  
Cytochrome P 450
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