Prenatal screening for Down's syndrome and human chorionic gonadotropin isoforms

1993 ◽  
Vol 223 (1-2) ◽  
pp. 173-177
Author(s):  
Philippe Defasque ◽  
Pascal Pigny ◽  
André Racadot ◽  
Jean-Pierre Farriaux ◽  
Arnold Boersma
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Prenatal Screening ◽  
Down's Syndrome ◽  
Down’S Syndrome

Free β-Chorionic Gonadotropin: A Cross-Reactivity Study of Two Immunometric Assays Used in Prenatal Maternal Serum Screening for Down's Syndrome

1993 ◽  
Vol 30 (1) ◽  
pp. 94-98 ◽  
Author(s):  
James N Macri ◽  
Kevin Spencer ◽  
Robert W Anderson ◽  
Edward J Cook
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Detection Efficiency ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Cross Reactivity ◽  
Maternal Serum ◽  
Glycoprotein Hormones ◽  
Maternal Serum Screening ◽  
Reactivity Study

We have evaluated the cross-reactivity characteristics of two distinct immunometric assays for the measurement of free β-human chorionic gonadotropin (free β). These maternal serum assays have been used in the initial studies which evaluated free β as a marker in the prenatal detection of Down's syndrome. It has been suggested that free β assays are subject to substantial potential for cross-reactivity. To confirm that free β was the analyte responsible for enhanced detection efficiency both non-competitive and competitive cross-reactivity evaluations were undertaken. These studies demonstrated acceptably small cross-reactivity to other glycoprotein hormones or their β components. We conclude that properly designed free β assays will provide specific analyte measurement and improved detection efficiency in Down's syndrome screening.

Defect of Syncytiotrophoblast Formation and Human Chorionic Gonadotropin Expression in Down's Syndrome

Placenta ◽  
2001 ◽  
Vol 22 ◽  
pp. S93-S97 ◽  
Author(s):  
N. Massin ◽  
J-L. Frendo ◽  
J. Guibourdenche ◽  
D. Luton ◽  
Y. Giovangrandi ◽  
...  
Keyword(s):  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Down's Syndrome ◽  
Down’S Syndrome

Prenatal screening for Down's syndrome

1992 ◽  
Vol 6 (2) ◽  
pp. 179
Author(s):  
J. Caesar ◽  
B. Bockel ◽  
M. Krawczak ◽  
M. Thiele ◽  
B. Hoppe-Sievert ◽  
...  
Keyword(s):  
Prenatal Screening ◽  
Down's Syndrome ◽  
Down’S Syndrome
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