Nonlinear least-squares regression analysis in pharmacokinetics: Application of a programmable calculator in model parameter estimation

1980 ◽  
Vol 13 (4) ◽  
pp. 307-316 ◽  
Author(s):  
Keith T. Muir
Keyword(s):  
Parameter Estimation ◽  
Regression Analysis ◽  
Least Squares ◽  
Nonlinear Least Squares ◽  
Least Squares Regression ◽  
Programmable Calculator ◽  
Model Parameter ◽  
Model Parameter Estimation

A New Programmable Calculator Procedure for Individualizing Phenytoin Dosage

1983 ◽  
Vol 17 (12) ◽  
pp. 890-893 ◽  
Author(s):  
Andrea Messori ◽  
Tommaso Valenza ◽  
Gaetano Zaccara ◽  
Graziano Arnetoli ◽  
Carlo Bartoli ◽  
...  
Keyword(s):  
Parameter Estimation ◽  
Least Squares ◽  
Theoretical Approach ◽  
Nonlinear Least Squares ◽  
Computer Programs ◽  
Pharmacokinetic Data ◽  
Programmable Calculator ◽  
Model Parameter ◽  
Least Squares Fit ◽  
Programming Skill

A programmable calculator procedure allowing nonlinear least-squares fit to pharmacokinetic data conforming to the Michaelis-Menten model is described. Model parameter estimation is performed according to the iterative Gauss-Newton technique as modified by Hartley. This procedure thus employs the same theoretical approach used by most pharmacokinetic computer programs. No programming skill is needed to run the program described. The proposed procedure is discussed in detail and applied to some sets of pharmacokinetic data.

Model-parameter estimation using least squares

1992 ◽  
Vol 26 (6) ◽  
pp. 789-796 ◽  
Author(s):  
Pablo B. Sáez ◽  
Bruce E. Rittmann
Keyword(s):  
Parameter Estimation ◽  
Least Squares ◽  
Model Parameter ◽  
Model Parameter Estimation
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