Benzodiazepine receptors studied in living primates by positron emission tomography: inverse agonist interactions

1987 ◽  
Vol 138 (2) ◽  
pp. 239-247 ◽  
Author(s):  
Philippe Hantraye ◽  
Chantal Chavoix ◽  
Bernard Guibert ◽  
Hiroshi Fukuda ◽  
Emmanuel Brouillet ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Benzodiazepine Receptors ◽  
Inverse Agonist ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Positron Emission Tomography Study of Brain Benzodiazepine Receptors in Friedreich's Ataxia

1990 ◽  
Vol 17 (4) ◽  
pp. 404-409 ◽  
Author(s):  
C. Chavoix ◽  
Y. Samson ◽  
S. Pappata ◽  
C. Prenant ◽  
M. Mazière ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Benzodiazepine Receptors ◽  
Friedreich’S Ataxia ◽  
Friedreich's Ataxia ◽  
Emission Tomography ◽  
Tracer Injection ◽  
Central Type ◽  
Positron Emission ◽  
Specific Antagonist ◽  
Kinetics Of

ABSTRACT:Central type benzodiazepine receptors were studied in 9 patients with Friedreich's ataxia and 12 healthy subjects using positron emission tomography (PET) and [11C]Ro 15-1788, a specific antagonist of the central type benzodiazepine receptors, as radioligand. A standard PET procedure was used in 5 patients and 8 controls to obtain brain kinetics of the total binding of the radioligand. The remaining subjects were intravenously injected with a saturating dose of unlabeled Ro 15-1788, 30 minutes after the tracer injection, to determine the nondisplaceable binding of [11C]Ro 15-1788. A semi-quantitative method was used to quantify the [11C]Ro 15-1788 data. None of the quantification indices in the cerebellar hemispheres, or in the other brain areas investigated, was significantly modified in patients with Friedreich's ataxia. These findings suggest that brain benzodiazepine receptors are unaffected in Friedreich's ataxia.

scholarly journals Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand

NeuroImage ◽  
2009 ◽  
Vol 48 (2) ◽  
pp. 362-370 ◽  
Author(s):  
Garth E. Terry ◽  
Jeih-San Liow ◽  
Sami S. Zoghbi ◽  
Jussi Hirvonen ◽  
Amanda G. Farris ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Human Brain ◽  
Inverse Agonist ◽  
Emission Tomography ◽  
Cb1 Receptors ◽  
Healthy Human ◽  
Positron Emission
Sign in / Sign up

Export Citation Format

Share Document