Bacteroides fragilis toxin demonstrates polar action on the cytoskeleton and chloride secretion of T84 monolayers

1995 ◽  
Vol 108 (4) ◽  
pp. A321
Author(s):  
Michael P. Goheen ◽  
Charles E. Edmiston

The synergistic activity of antimicrobial combinants against aerobic and facultative microorganisms has been well documented. in comparison, few studies have been performed using obligate anaerobic isolates and antimicrobial combinants. For this study clinical strains of Bacteroides fragilis(BF) were selected to investigate both single/combinant drug activity and cellular morphologic changes when BF is exposed to Imipenem (I), Piperacillin (P), Cefpimizole (C), Imipenem/Piperacillin (I+P), and Imipenem/Cefpimizole (I+C).


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