Noticeable levels of reduced antimicrobial susceptibility in Bacteroides fragilis group bacteria isolated from faecal samples from healthy children in Denmark

2016 ◽  
Author(s):  
Thomas Vognbjerg Sydenham
Keyword(s):  
Antimicrobial Susceptibility ◽  
Bacteroides Fragilis ◽  
Healthy Children ◽  
Faecal Samples ◽  
Bacteroides Fragilis Group

scholarly journals Effect of pH on in vitro antimicrobial susceptibility of the Bacteroides fragilis group.

1997 ◽  
Vol 41 (9) ◽  
pp. 2047-2049 ◽  
Author(s):  
M E Falagas ◽  
L McDermott ◽  
D R Snydman
Keyword(s):  
Antimicrobial Susceptibility ◽  
Ph Effect ◽  
Geometric Mean ◽  
Bacteroides Fragilis ◽  
Acidic Ph ◽  
Effect Of Ph ◽  
Bacteroides Fragilis Group ◽  
Group Species

We studied the effect of pH (7.1, 6.3, and 5.8) on the in vitro susceptibilities of 59 isolates of Bacteroides fragilis and 60 isolates of other B. fragilis group species to trovafloxacin, ciprofloxacin, clindamycin, ampicillin-sulbactam, piperacillin-tazobactam, imipenem, and meropenem. For each agent tested the geometric mean MIC was highest at pH 5.8, intermediate at pH 6.3, and lowest at pH 7.1. The magnitude of the pH effect varied greatly among different antibiotics. These data show that an acidic pH decreases the in vitro susceptibilities of the B. fragilis group to several antibiotics.

scholarly journals Surveillance of Antimicrobial Susceptibility of Anaerobe Clinical Isolates in Southeast Austria: Bacteroides fragilis Group Is on the Fast Track to Resistance

Antibiotics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 479
Author(s):  
Elisabeth König ◽  
Hans P. Ziegler ◽  
Julia Tribus ◽  
Andrea J. Grisold ◽  
Gebhard Feierl ◽  
...  
Keyword(s):  
Antimicrobial Susceptibility ◽  
Anaerobic Bacteria ◽  
Bacteroides Fragilis ◽  
Beta Lactam ◽  
Gram Positive ◽  
Beta Lactam Antibiotics ◽  
Disk Diffusion Testing ◽  
Bacteroides Fragilis Group ◽  
Resistance Rates ◽  
Human Infections

Anaerobic bacteria play an important role in human infections. Bacteroides spp. are some of the 15 most common pathogens causing nosocomial infections. We present antimicrobial susceptibility testing (AST) results of 114 Gram-positive anaerobic isolates and 110 Bacteroides-fragilis-group-isolates (BFGI). Resistance profiles were determined by MIC gradient testing. Furthermore, we performed disk diffusion testing of BFGI and compared the results of the two methods. Within Gram-positive anaerobes, the highest resistance rates were found for clindamycin and moxifloxacin (21.9% and 16.7%, respectively), and resistance for beta-lactams and metronidazole was low (<1%). For BFGI, the highest resistance rates were also detected for clindamycin and moxifloxacin (50.9% and 36.4%, respectively). Resistance rates for piperacillin/tazobactam and amoxicillin/clavulanic acid were 10% and 7.3%, respectively. Two B. fragilis isolates were classified as multi-drug-resistant (MDR), with resistance against all tested beta-lactam antibiotics. The comparative study of 109 BFGI resulted in 130 discrepancies in 763 readings (17%) with a high number of Very Major Errors (VME) and Major Errors (ME). In summary, resistance rates, with the exception of clindamycin and moxifloxacin, are still low, but we are facing increasing resistance rates for BFGI. Surveillance studies on a regular basis are still recommended.

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