Model system for study of virus-specific immune responses in gut-associated lymphoid tissue (GALT)

1995 ◽  
Vol 108 (4) ◽  
pp. A904
Keyword(s):  
Immune Responses ◽  
Lymphoid Tissue ◽  
Model System

scholarly journals Lymphocyte Homing to Bronchus-associated Lymphoid Tissue (BALT) Is Mediated by L-selectin/PNAd, α4β1 Integrin/VCAM-1, and LFA-1 Adhesion Pathways

2003 ◽  
Vol 197 (10) ◽  
pp. 1255-1267 ◽  
Author(s):  
Baohui Xu ◽  
Norbert Wagner ◽  
Linh Nguyen Pham ◽  
Vincent Magno ◽  
Zhongyan Shan ◽  
...  
Keyword(s):  
Immune Responses ◽  
Lymphoid Tissue ◽  
Lymphoid Tissues ◽  
Lymphocyte Migration ◽  
High Endothelial Venules ◽  
Level Of Involvement ◽  
Selectin Ligand ◽  
High Level ◽  
Migration Pathways ◽  
B And T Lymphocytes

Bronchus-associated lymphoid tissue (BALT) participates in airway immune responses. However, little is known about the lymphocyte–endothelial adhesion cascades that recruit lymphocytes from blood into BALT. We show that high endothelial venules (HEVs) in BALT express substantial levels of VCAM-1, in marked contrast to HEVs in other secondary lymphoid tissues. BALT HEVs also express the L-selectin ligand PNAd. Anti–L-selectin, anti-PNAd, and anti–LFA-1 mAbs almost completely block the homing of B and T lymphocytes into BALT, whereas anti–α4 integrin and anti–VCAM-1 mAbs inhibit homing by nearly 40%. α4β7 integrin and MAdCAM-1 are not involved. Importantly, we found that mAbs against α4 integrin and VCAM-1 significantly block the migration of total T cells (80% memory phenotype) but not naive T and B cells to BALT. These results suggest that an adhesion cascade, which includes L-selectin/PNAd, α4β1 integrin/VCAM-1, and LFA-1, targets specific lymphocyte subsets to BALT. This high level of involvement of α4β1 integrin/VCAM-1 is unique among secondary lymphoid tissues, and may help unify lymphocyte migration pathways and immune responses in BALT and other bronchopulmonary tissues.

scholarly journals Immunological association of inducible bronchus-associated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice

2018 ◽  
Vol 30 (10) ◽  
pp. 471-481 ◽  
Author(s):  
Takahiro Nagatake ◽  
Hidehiko Suzuki ◽  
So-ichiro Hirata ◽  
Naomi Matsumoto ◽  
Yasuko Wada ◽  
...  
Keyword(s):  
Immune Responses ◽  
Lymphoid Tissue ◽  
Mucosal Immune Responses

scholarly journals Prebiotics Modulate Immune Responses in the Gut-Associated Lymphoid Tissue of Chickens

2009 ◽  
Vol 139 (7) ◽  
pp. 1404-1409 ◽  
Author(s):  
Vijaya Janardhana ◽  
Mary M. Broadway ◽  
Matthew P. Bruce ◽  
John W. Lowenthal ◽  
Mark S. Geier ◽  
...  
Keyword(s):  
Immune Responses ◽  
Lymphoid Tissue

Liposomal α-galactosylceramide is taken up by gut-associated lymphoid tissue and stimulates local and systemic immune responses

2017 ◽  
Vol 69 (12) ◽  
pp. 1724-1735 ◽  
Author(s):  
Kan Kaneko ◽  
Arlene McDowell ◽  
Yasuyuki Ishii ◽  
Sarah Hook
Keyword(s):  
Immune Responses ◽  
Lymphoid Tissue

scholarly journals Nasal-Associated Lymphoid Tissue Is a Mucosal Inductive Site for Virus-Specific Humoral and Cellular Immune Responses

2002 ◽  
Vol 168 (4) ◽  
pp. 1796-1803 ◽  
Author(s):  
Adrian W. Zuercher ◽  
Susan E. Coffin ◽  
M. Christine Thurnheer ◽  
Petra Fundova ◽  
John J. Cebra
Keyword(s):  
Immune Responses ◽  
Lymphoid Tissue ◽  
Cellular Immune Responses ◽  
Cellular Immune

Splenomegaly and other disorders of the spleen

2018 ◽  
Author(s):  
Chris Bunch
Keyword(s):  
Particulate Matter ◽  
Immune Responses ◽  
Lymphoid Tissue ◽  
Lymphoid Organ ◽  
Dual Role ◽  
White Pulp ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Upper Abdomen ◽  
Red Pulp

The spleen is a predominantly lymphoid organ, normally about the size of a clenched fist located beneath the diaphragm in the left upper abdomen. It has a dual role as a filter for the circulation, and a primary lymphoid organ in its own right. About three-quarters of its volume is a matrix of capillaries and sinuses (the red pulp), through which blood is able to percolate slowly and come into contact with fixed macrophages, which are able to remove senescent or damaged red cells, or other particulate matter such as bacteria. The lymphoid tissue is organized into scattered follicles (the white pulp), which have a particularly important role in initiating primary humoral immune responses and antibody (IgM) synthesis. The spleen commonly enlarges when either its filtration function is increased—as in haemolysis—or it is stimulated by infection or inflammation. It may also be involved in myeloproliferative and lymphoproliferative neoplasias. This chapter covers hypersplenism, splenectomy, hyposplenism, overwhelming post-splenectomy infection (OPSI), and other infections in hyposplenic patients.

Significance of Immune Responses to Mucosal Carcinogens: A Hypothesis and a Workable Model System

1986 ◽  
Vol 5 (3-5) ◽  
pp. 265-277 ◽  
Author(s):  
David F. Keren ◽  
Lawrence K. Silbart ◽  
Pamela M. Lincoln ◽  
Thomas M. Annesley
Keyword(s):  
Immune Responses ◽  
Model System

Inhibition of Cell Proliferation in Renal Failure and its Significance to the Uraemic Syndrome: A Review

1975 ◽  
Vol 20 (6) ◽  
pp. 317-327 ◽  
Author(s):  
Frances T. McDermott ◽  
Andrew J. Galbraith ◽  
Russell J. Corlett
Keyword(s):  
Cell Proliferation ◽  
Renal Failure ◽  
Immune Responses ◽  
Lymphoid Tissue ◽  
Kinetic Studies ◽  
Inhibitory Effect ◽  
Impaired Wound Healing ◽  
Population Kinetic ◽  
Generation Cycle ◽  
Proliferative Cell

The effect of acute and chronic renal failure on cell proliferation in rapidly dividing tissues has been examined in man and animal models. The evidence reviewed supports the hypothesis that renal failure results in a general inhibition of cell proliferation. Cell population kinetic studies of gastrointestinal and skin epithelia in experimental acute renal failure show a prolongation of the cell generation cycle. Less detailed investigations of other proliferative cell systems indicate an inhibitory effect on proliferation within the generative compartment of the erythroid series, lymphoid tissue, seminiferous epithelia and wound granulation tissue. This inhibition appears partly responsible for anaemia and impaired wound healing and may contribute to the abnormal immune responses, gastrointestinal tract lesions and male sterility found in renal failure.

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