Liposomal α-galactosylceramide is taken up by gut-associated lymphoid tissue and stimulates local and systemic immune responses

2017 ◽  
Vol 69 (12) ◽  
pp. 1724-1735 ◽  
Author(s):  
Kan Kaneko ◽  
Arlene McDowell ◽  
Yasuyuki Ishii ◽  
Sarah Hook
Keyword(s):  
Immune Responses ◽  
Lymphoid Tissue

scholarly journals Lymphocyte Homing to Bronchus-associated Lymphoid Tissue (BALT) Is Mediated by L-selectin/PNAd, α4β1 Integrin/VCAM-1, and LFA-1 Adhesion Pathways

2003 ◽  
Vol 197 (10) ◽  
pp. 1255-1267 ◽  
Author(s):  
Baohui Xu ◽  
Norbert Wagner ◽  
Linh Nguyen Pham ◽  
Vincent Magno ◽  
Zhongyan Shan ◽  
...  
Keyword(s):  
Immune Responses ◽  
Lymphoid Tissue ◽  
Lymphoid Tissues ◽  
Lymphocyte Migration ◽  
High Endothelial Venules ◽  
Level Of Involvement ◽  
Selectin Ligand ◽  
High Level ◽  
Migration Pathways ◽  
B And T Lymphocytes

Bronchus-associated lymphoid tissue (BALT) participates in airway immune responses. However, little is known about the lymphocyte–endothelial adhesion cascades that recruit lymphocytes from blood into BALT. We show that high endothelial venules (HEVs) in BALT express substantial levels of VCAM-1, in marked contrast to HEVs in other secondary lymphoid tissues. BALT HEVs also express the L-selectin ligand PNAd. Anti–L-selectin, anti-PNAd, and anti–LFA-1 mAbs almost completely block the homing of B and T lymphocytes into BALT, whereas anti–α4 integrin and anti–VCAM-1 mAbs inhibit homing by nearly 40%. α4β7 integrin and MAdCAM-1 are not involved. Importantly, we found that mAbs against α4 integrin and VCAM-1 significantly block the migration of total T cells (80% memory phenotype) but not naive T and B cells to BALT. These results suggest that an adhesion cascade, which includes L-selectin/PNAd, α4β1 integrin/VCAM-1, and LFA-1, targets specific lymphocyte subsets to BALT. This high level of involvement of α4β1 integrin/VCAM-1 is unique among secondary lymphoid tissues, and may help unify lymphocyte migration pathways and immune responses in BALT and other bronchopulmonary tissues.

scholarly journals Immunological association of inducible bronchus-associated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice

2018 ◽  
Vol 30 (10) ◽  
pp. 471-481 ◽  
Author(s):  
Takahiro Nagatake ◽  
Hidehiko Suzuki ◽  
So-ichiro Hirata ◽  
Naomi Matsumoto ◽  
Yasuko Wada ◽  
...  
Keyword(s):  
Immune Responses ◽  
Lymphoid Tissue ◽  
Mucosal Immune Responses

scholarly journals Prebiotics Modulate Immune Responses in the Gut-Associated Lymphoid Tissue of Chickens

2009 ◽  
Vol 139 (7) ◽  
pp. 1404-1409 ◽  
Author(s):  
Vijaya Janardhana ◽  
Mary M. Broadway ◽  
Matthew P. Bruce ◽  
John W. Lowenthal ◽  
Mark S. Geier ◽  
...  
Keyword(s):  
Immune Responses ◽  
Lymphoid Tissue

scholarly journals Nasal-Associated Lymphoid Tissue Is a Mucosal Inductive Site for Virus-Specific Humoral and Cellular Immune Responses

2002 ◽  
Vol 168 (4) ◽  
pp. 1796-1803 ◽  
Author(s):  
Adrian W. Zuercher ◽  
Susan E. Coffin ◽  
M. Christine Thurnheer ◽  
Petra Fundova ◽  
John J. Cebra
Keyword(s):  
Immune Responses ◽  
Lymphoid Tissue ◽  
Cellular Immune Responses ◽  
Cellular Immune

Splenomegaly and other disorders of the spleen

2018 ◽  
Author(s):  
Chris Bunch
Keyword(s):  
Particulate Matter ◽  
Immune Responses ◽  
Lymphoid Tissue ◽  
Lymphoid Organ ◽  
Dual Role ◽  
White Pulp ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Upper Abdomen ◽  
Red Pulp

The spleen is a predominantly lymphoid organ, normally about the size of a clenched fist located beneath the diaphragm in the left upper abdomen. It has a dual role as a filter for the circulation, and a primary lymphoid organ in its own right. About three-quarters of its volume is a matrix of capillaries and sinuses (the red pulp), through which blood is able to percolate slowly and come into contact with fixed macrophages, which are able to remove senescent or damaged red cells, or other particulate matter such as bacteria. The lymphoid tissue is organized into scattered follicles (the white pulp), which have a particularly important role in initiating primary humoral immune responses and antibody (IgM) synthesis. The spleen commonly enlarges when either its filtration function is increased—as in haemolysis—or it is stimulated by infection or inflammation. It may also be involved in myeloproliferative and lymphoproliferative neoplasias. This chapter covers hypersplenism, splenectomy, hyposplenism, overwhelming post-splenectomy infection (OPSI), and other infections in hyposplenic patients.

Inhibition of Cell Proliferation in Renal Failure and its Significance to the Uraemic Syndrome: A Review

1975 ◽  
Vol 20 (6) ◽  
pp. 317-327 ◽  
Author(s):  
Frances T. McDermott ◽  
Andrew J. Galbraith ◽  
Russell J. Corlett
Keyword(s):  
Cell Proliferation ◽  
Renal Failure ◽  
Immune Responses ◽  
Lymphoid Tissue ◽  
Kinetic Studies ◽  
Inhibitory Effect ◽  
Impaired Wound Healing ◽  
Population Kinetic ◽  
Generation Cycle ◽  
Proliferative Cell

The effect of acute and chronic renal failure on cell proliferation in rapidly dividing tissues has been examined in man and animal models. The evidence reviewed supports the hypothesis that renal failure results in a general inhibition of cell proliferation. Cell population kinetic studies of gastrointestinal and skin epithelia in experimental acute renal failure show a prolongation of the cell generation cycle. Less detailed investigations of other proliferative cell systems indicate an inhibitory effect on proliferation within the generative compartment of the erythroid series, lymphoid tissue, seminiferous epithelia and wound granulation tissue. This inhibition appears partly responsible for anaemia and impaired wound healing and may contribute to the abnormal immune responses, gastrointestinal tract lesions and male sterility found in renal failure.

scholarly journals The role of personal hygiene on non complicated pediatric appendicitis patients

2018 ◽  
Vol 5 (5) ◽  
pp. 1614
Author(s):  
Budhi Ida Bagus ◽  
Azka Rumaisha ◽  
Suwardi Suwardi ◽  
Yudhani Ratih Dewi
Keyword(s):  
Immune Responses ◽  
Lymphoid Tissue ◽  
Sampling Method ◽  
Observational Research ◽  
Personal Hygiene ◽  
The Poor ◽  
Common Etiology ◽  
Independent Variable ◽  
Emergency Abdominal Surgery

Background: Appendicitis is an inflammation that occurs in appendix vermiformis and is the most common cause of abdominal pain. Appendicitis is also an indication of emergency abdominal surgery in children. The incidence of child appendicitis is 1.66 per 1000. If the diagnosis is delayed, 97% of cases of acute appendicitis will lead to perforation with a mortality rate of 5.1 per 1000 cases. The most common etiology of appendicitis is lymphoid tissue hyperplasia which represents one of the immune responses to infection. One of the infection factors was the poor personal hygiene level. This research aimed to discover personal hygiene level description in pediatric non complicated appendicitis.Methods: This research used descriptive quantitative observational research conducted in Moewardi General Hospital Surakarta. The sampling method was total sampling in appendicitis patient with, 33 respondents. Assessment in patients was calculated using personal hygiene scale questionnaire consisting of 12 items. The independent variable in this research was personal hygiene level, and the dependent variable was the incidence of pediatric appendicitis. Data were analyzed statistically for descriptive analysis.Results: The result showed that 51.5% of patients with pediatric appendicitis had poor personal hygiene.  Conclusions: Pediatric appendicitis patient had poor personal hygiene level.

scholarly journals Histogenesis of Human Fetal Spleen

2017 ◽  
Vol 06 (01) ◽  
pp. 01-08
Author(s):  
Sonali Thomas ◽  
DN Sinha ◽  
AK Singh ◽  
Deepa Deopa ◽  
Richa Niranjan
Keyword(s):  
Immune Responses ◽  
Lymphoid Tissue ◽  
Light Microscope ◽  
Lymphoid Follicle ◽  
Germinal Centers ◽  
Human Fetuses ◽  
Government Hospital ◽  
Lymphatic Organ ◽  
Haemopoietic Cells ◽  
Literature Material

Abstract Background and Aims: Spleen is the largest secondary lymphatic organ. It acts as a graveyard for RBCs, is essential for immune responses, performs lymphopoiesis in adults and haemopoiesis in fetuses. The present study was conducted to assess the histogenesis of spleen in human fetuses in view of existing literature. Material and Methods: The study was carried out on 34 formalin preserved human fetuses procured from Dr Sushila Tiwari Government Hospital, Haldwani with due clearance from ethical committee. The 6 pm sections of the spleen were stained with Haematoxylin and Eosin and observed under light microscope. Results: At 14 tol5 weeks, spleen had extensive sinusoids filled with RBCs and few lymphocytes. At 16-18 weeks, trabecular arteries were noticed more towards centre along with extensive haemopoietic cells in the venous sinusoids. By 20th week lymphocytic aggregation had started around arterioles. By 24 weeks periarteriolar lymphatic sheath was clearly observed. At term (37-40 weeks), classical primary lymphoid follicle was present but germinal centers were not observed. Conclusion: During earlier differentiation, spleen symbolizes the function of haemopoietic activities and gradually during subsequent gestation; it establishes its identity as a principle lymphoid tissue.

Sign in / Sign up

Export Citation Format

Share Document