Identification of pharmacokinetic parameters of two compartment open model with first order absorption

1985 ◽  
Vol 16 (2) ◽  
pp. 127-133 ◽  
Author(s):  
Y. Cherruault ◽  
V.B. Sarin
Keyword(s):  
Pharmacokinetic Parameters ◽  
Open Model ◽  
First Order ◽  
Compartment Open Model

Ketamine kinetics: decerebrate vs. intact cats

1979 ◽  
Vol 57 (8) ◽  
pp. 878-881 ◽  
Author(s):  
James E. Heavner ◽  
Duane C. Bloedow
Keyword(s):  
Apparent Volume ◽  
Volume Of Distribution ◽  
Drug Dose ◽  
The Body ◽  
Pharmacokinetic Parameters ◽  
Peripheral Compartment ◽  
Blood Concentrations ◽  
Open Model ◽  
Apparent Volume Of Distribution ◽  
Compartment Open Model

Pharmacokinetic parameters of a ketamine (10 mg/kg, iv) bolus in decerebrate and intact cats were compared. A two-compartment open model best described the data in both groups. The apparent volume of distribution of the peripheral compartment, the apparent volume of distribution of the drug in the body, and the half-life of the postdistributive phase were significantly less (p < 0.05) in the decerebrate animals. These results emphasize the importance of correlating behavior and neuronal activity with plasma or blood concentrations of drug in animals rather than assuming that, for a given drug dose, blood (and thus tissue) levels of the agent will be similar regardless of how the animal is prepared for study.

Pharmacokinetic Predictions Based on a Variable Dosage Frequency in Chronic Treatment

1983 ◽  
Vol 17 (4) ◽  
pp. 290-292 ◽  
Author(s):  
Andrea Messori ◽  
Giancarlo Donati-Cori ◽  
Enrico Tendi
Keyword(s):  
Oral Administration ◽  
Chronic Treatment ◽  
Plasma Drug ◽  
Programmable Calculator ◽  
Open Model ◽  
Dosing Interval ◽  
Drug Levels ◽  
First Order ◽  
Compartment Open Model ◽  
Dosage Frequency

After repeated intramuscular or oral administration, plasma drug levels are predicted by using a programmable calculator. Predictions are based on a one-compartment, open model with first-order absorption. The actual times of dosing are considered, so that the assumption of a constant dosing interval is not required. A brief analysis of the pharmacokinetic consequences that may result from a variable dosage frequency is presented.

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