Estimation of Pharmacokinetic Parameters Using Nonlinear Fixed Effects One Compartment Open Model

Pharmacokinetic parameters of a ketamine (10 mg/kg, iv) bolus in decerebrate and intact cats were compared. A two-compartment open model best described the data in both groups. The apparent volume of distribution of the peripheral compartment, the apparent volume of distribution of the drug in the body, and the half-life of the postdistributive phase were significantly less (p < 0.05) in the decerebrate animals. These results emphasize the importance of correlating behavior and neuronal activity with plasma or blood concentrations of drug in animals rather than assuming that, for a given drug dose, blood (and thus tissue) levels of the agent will be similar regardless of how the animal is prepared for study.

Download Full-text

Identification of pharmacokinetic parameters of two compartment open model with first order absorption

International Journal of Bio-Medical Computing ◽

10.1016/0020-7101(85)90013-3 ◽

1985 ◽

Vol 16 (2) ◽

pp. 127-133 ◽

Cited By ~ 5

Author(s):

Y. Cherruault ◽

V.B. Sarin

Keyword(s):

Pharmacokinetic Parameters ◽

Open Model ◽

First Order ◽

Compartment Open Model

Download Full-text

Estimation of the pharmacokinetic parameters of the two-compartment open model from post-infusion plasma concentration data

Journal of Pharmaceutical Sciences ◽

10.1002/jps.2600580921 ◽

1969 ◽

Vol 58 (9) ◽

pp. 1133-1135 ◽

Cited By ~ 18

Author(s):

Milo Gibaldi

Keyword(s):

Plasma Concentration ◽

Pharmacokinetic Parameters ◽

Concentration Data ◽

Open Model ◽

Post Infusion ◽

Compartment Open Model

Download Full-text

Estimation of Population Pharmacokinetic Parameters Using Destructively Obtained Experimental Data: A Simulation Study of the One-Compartment Open Model

Drug Metabolism Reviews ◽

10.3109/03602538409015065 ◽

1984 ◽

Vol 15 (1-2) ◽

pp. 195-264 ◽

Cited By ~ 16

Author(s):

F. Tom Lindstrom ◽

David S. Birkes

Keyword(s):

Experimental Data ◽

Simulation Study ◽

Pharmacokinetic Parameters ◽

Population Pharmacokinetic ◽

Open Model ◽

The One ◽

Compartment Open Model

Download Full-text

In VitroDissolution andIn VivoBioavailability of Six Brands of Ciprofloxacin Tablets Administered in Rabbits and Their Pharmacokinetic Modeling

BioMed Research International ◽

10.1155/2014/590848 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 5

Author(s):

Sahar Fahmy ◽

Eman Abu-Gharbieh

Keyword(s):

Pharmacokinetic Modeling ◽

Pharmacokinetic Parameters ◽

Noncompartmental Analysis ◽

Dose Oral ◽

Generic Products ◽

Ensure Product Quality ◽

Pharmacopoeial Requirements ◽

Compartment Open Model

This study was undertaken to assess thein vitrodissolution andin vivobioavailability of six brands of ciprofloxacin oral tablets available in the UAE market using rabbits. Thein vitrodissolution profiles of the six ciprofloxacin products were determined using the USP dissolution paddle method. Pharmacokinetic modeling using compartmental and noncompartmental analysis was done to determine the pharmacokinetic parameters of ciprofloxacin after single-dose oral administration.In vitrorelease study revealed that the amount of ciprofloxacin released in 20 minutes was not less than 80% of the labeled amount which is in accordance with the pharmacopoeial requirements. All tested products are considered to be very rapid dissolving except for formulae A and D. Ciprofloxacin plasma concentration in rabbits was best fitted to a two-compartment open model. The lowest bioavailability was determined to be for product A (93.24%) while the highest bioavailability was determined to be for product E (108.01%). Postmarketing surveillance is very crucial to ensure product quality and eliminating substandard products to be distributed and, consequently, ensure better patient clinical outcome. The tested ciprofloxacin generic products distributed in the UAE market were proven to be of good quality and could be used interchangeably with the branded ciprofloxacin product.

Download Full-text

A model system for investigating the biliary excretion of an anion in the rat

Biochemical Journal ◽

10.1042/bj1480303 ◽

1975 ◽

Vol 148 (2) ◽

pp. 303-307 ◽

Cited By ~ 3

Author(s):

G M Powell ◽

J G Jones ◽

A H Olavesen ◽

C G Curtis

Keyword(s):

Kinetic Analysis ◽

Continuous Infusion ◽

Biliary Excretion ◽

Essential Feature ◽

Model System ◽

Open Model ◽

Compartment Open Model

1. The biliary excretion of phenolphthalein di[35S]sulphate was studied in rats. 2. The conjugate was administered by continuous infusion at rates of 3, 4.5, 6, 9 and 12 mug/min, and kinetic analysis of the rate of biliary excretion was consistent with a two-compartment open-model system. 3. The results obtained after single injections of the ester were also consistent with the model. 4. An essential feature of the model is the presence of a compartment into which the ester may pass as an alternative to direct excretion via the bile. 5. It is suggested that such a compartment may be located within the liver.

Download Full-text