The differential diagnosis of neonatal hepatitis and biliary atresia

1974 ◽  
Vol 9 (5) ◽  
pp. 699-705 ◽  
Author(s):  
David P. Campbell ◽  
J.Rainer Poley ◽  
Petar Alaupovic ◽  
E.Ide Smith
Keyword(s):  
Differential Diagnosis ◽  
Biliary Atresia ◽  
Neonatal Hepatitis

99mTc sestamibi imaging

2009 ◽  
Vol 48 (03) ◽  
pp. 100-103 ◽  
Author(s):  
H. R. Kianifar ◽  
V. R. D. Kakhki ◽  
R. Zakavi ◽  
K. Ansari ◽  
R. Sadeghi
Keyword(s):  
Differential Diagnosis ◽  
Biliary Atresia ◽  
Neonatal Hepatitis ◽  
Hepatobiliary Scintigraphy ◽  
Neonatal Cholestasis ◽  
Major Disadvantage ◽  
99Mtc Mibi ◽  
Diagnostic Work ◽  
Mibi Scintigraphy ◽  
99Mtc Sestamibi

Summary Aim: Hepatobiliary scintigraphy is an integral part in the diagnostic work-up of the neonatal cholestasis syndrome. However, less than optimal specificity is its major disadvantage. Differentiation between biliary atresia and neonatal hepatitis is nearly impossible in some cases with poor hepatocellular function. 99mTc sestamibi (MIBI) is a cationic lipophilic agent which is a substrate of P-glycoprotein. This glycoprotein is normally expressed in biliary canalicular surfaces of hepatocytes. This property provides a hepatic excretory mechanism which is different from bilirubin excretion. In this study we evaluated the value of 99mTc MIBI in differential diagnosis of neonatal cholestasis. Patients, methods: 20 infants with a mean age of 2.41 months (range, 0.1–5 months) were included in the study. Ten infants turned out to have extrahepatic biliary atresia and the other ten had neonatal hepatitis. Hepatobiliary (with 99mTc BrIDA) and 99mTc MIBI scintigraphy were performed for all the patients. Results: 99mTc MIBI scintigraphy has shown bowel activity in all patients, including the patients with biliary atresia. Hepatobiliary scintigraphy revealed bowel activity only in five patients with neo natal hepatitis. Conclusion: Bowel visualization with 99mTc MIBI may be seen in patients with biliary atresia and 99mTc MIBI has limited value in differential diagnosis of neonatal chole stasis.

THE RED CELL PEROXIDE HEMOLYSIS TEST IN THE DIFFERENTIAL DIAGNOSIS OF OBSTRUCTIVE JAUNDICE IN THE NEWBORN PERIOD

PEDIATRICS ◽  
1971 ◽  
Vol 48 (4) ◽  
pp. 562-565
Author(s):  
Bertram H. Lubin ◽  
Robert L. Baehner ◽  
Elias Schwartz ◽  
Stephen B. Shohet ◽  
David G. Nathan
Keyword(s):  
Differential Diagnosis ◽  
Obstructive Jaundice ◽  
Biliary Atresia ◽  
Rose Bengal ◽  
Biliary Obstruction ◽  
The Other ◽  
Neonatal Hepatitis ◽  
Red Cell ◽  
Newborn Period ◽  
Hemolysis Test

The erythrocyte peroxide hemolysis test (PHT) was compared to the I131 rose bengal excretion test (RBE) in the detection of complete biliary obstruction in the newborn period. Twenty-three infants with obstructive jaundice were studied. In 16 infants with surgically proven biliary atresia both the PHT and RBE were abnormal. During the course of evaluation of the other seven patients, with neonatal hepatitis, the PHT was normal in six and abnormal in one, whereas, RBE was normal in two patients and abnormal in five. The simplicity and reliability of the PHT and the ease with which it can be repeated indicate that it may be more valuable than the RBE in evaluating the cause of obstructive jaundice in infants.

Differential Diagnosis of Extrahepatic Biliary Atresia from Neonatal Hepatitis

1994 ◽  
Vol 18 (2) ◽  
pp. 121-127 ◽  
Author(s):  
Ming-Wei Lai ◽  
Mei-Hwei Chang ◽  
Shun-Chien Hsu ◽  
Hey-Chi Hsu ◽  
Cheng-Tau Su ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Biliary Atresia ◽  
Neonatal Hepatitis ◽  
Extrahepatic Biliary Atresia

The role of CK7, Ki-67, CD34 and vimentin in the differentiation between biliary atresia and idiopathic neonatal hepatitis in Egyptian cholestatic neonates

Apmis ◽  
2012 ◽  
Vol 120 (7) ◽  
pp. 529-538 ◽  
Author(s):  
HAYAM ABDEL SAMIE AIAD ◽  
MONA ABDEL HALIM KANDIL ◽  
REHAB MONIR SAMAKA ◽  
MERVAT MAHMOUD SULTAN ◽  
MOHAMED TAWFIK BADR ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Neonatal Hepatitis ◽  
Ki 67 ◽  
Idiopathic Neonatal Hepatitis

Idiopathic Neonatal Hepatitis in One DNA Fingerprint Identical Twin

PEDIATRICS ◽  
1992 ◽  
Vol 89 (2) ◽  
pp. 329-330
Author(s):  
PIETRO VAJRO ◽  
ANGIOLA FONTANELLA ◽  
EMILIA VUTTARIELLO ◽  
ANNA DE VINCENZO ◽  
GIULIANA FORTUNATO
Keyword(s):  
Biliary Atresia ◽  
Hepatobiliary Disease ◽  
Identical Twin ◽  
Dna Fingerprint ◽  
Neonatal Hepatitis ◽  
Neonatal Cholestasis ◽  
Injury Site ◽  
Extrahepatic Biliary Atresia ◽  
Dizygotic Twins ◽  
Idiopathic Neonatal Hepatitis

For the practicing pediatrician, the most commonly encountered causes of neonatal cholestasis are idiopathic neonatal hepatitis (INH) and extrahepatic biliary atresia (EHBA). However, despite extensive research, little improvement in our understanding of the etiology of INH and EHBA has occurred.1 It has been proposed that both of them may be part of a continuum of hepatobiliary disease caused by a common insult with a different predominant injury site.2 In this respect, it is interesting that, up to the present, several cases of discordance for EHBA in twins of various zygosity have been reported,3-8 whereas no data are available about either concordance or discordance for INH both in monozygotic and dizygotic twins.

scholarly journals Neonatal hepatitis and biliary atresia: John E. Fogarty symposium

1980 ◽  
Vol 78 (4) ◽  
pp. 875-876
Author(s):  
Babu S. Bangaru ◽  
Murray Davidson
Keyword(s):  
Biliary Atresia ◽  
Neonatal Hepatitis
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