Idiopathic Neonatal Hepatitis in One DNA Fingerprint Identical Twin

PEDIATRICS ◽  
1992 ◽  
Vol 89 (2) ◽  
pp. 329-330
Author(s):  
PIETRO VAJRO ◽  
ANGIOLA FONTANELLA ◽  
EMILIA VUTTARIELLO ◽  
ANNA DE VINCENZO ◽  
GIULIANA FORTUNATO
Keyword(s):  
Biliary Atresia ◽  
Hepatobiliary Disease ◽  
Identical Twin ◽  
Dna Fingerprint ◽  
Neonatal Hepatitis ◽  
Neonatal Cholestasis ◽  
Injury Site ◽  
Extrahepatic Biliary Atresia ◽  
Dizygotic Twins ◽  
Idiopathic Neonatal Hepatitis

For the practicing pediatrician, the most commonly encountered causes of neonatal cholestasis are idiopathic neonatal hepatitis (INH) and extrahepatic biliary atresia (EHBA). However, despite extensive research, little improvement in our understanding of the etiology of INH and EHBA has occurred.1 It has been proposed that both of them may be part of a continuum of hepatobiliary disease caused by a common insult with a different predominant injury site.2 In this respect, it is interesting that, up to the present, several cases of discordance for EHBA in twins of various zygosity have been reported,3-8 whereas no data are available about either concordance or discordance for INH both in monozygotic and dizygotic twins.

Serum 5’-Nucleotidase in Neonatal Hepatitis and Biliary Atresia: Preliminary Observations

PEDIATRICS ◽  
1972 ◽  
Vol 50 (5) ◽  
pp. 812-814
Author(s):  
C. Y. YEUNG
Keyword(s):  
Bile Duct ◽  
Biliary Atresia ◽  
Diagnostic Value ◽  
Hepatobiliary Disease ◽  
Neonatal Hepatitis ◽  
Bile Duct Proliferation ◽  
Extrahepatic Biliary Atresia

This study is in agreement with the observation that the serum 5’ nucleotidase level is related to the degree of bile duct proliferation in hepatobiliary disease. In infants with congenital extrahepatic biliary atresia, where ductal proliferation is a feature, the enzyme levels are markedly raised and are significantly different from those with neonatal hepatitis. Such finding is of diagnostic value in differentiating between the two conditions.

scholarly journals Usefulness of clinical and laboratory parameters for differentiation of biliary atresia from idiopathic neonatal hepatitis: Experience in a tertiary care hospital of Bangladesh

2015 ◽  
Vol 4 (1) ◽  
pp. 30-36
Author(s):  
Kaniz Sultana ◽  
Ariful Haque ◽  
Nadira Musabbir ◽  
Syeda Afria Anwar ◽  
Faika Hussain ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Biliary Atresia ◽  
Tertiary Care ◽  
Neonatal Hepatitis ◽  
Care Hospital ◽  
Neonatal Cholestasis ◽  
Cross Sectional ◽  
Laboratory Parameters ◽  
Upper Limit ◽  
Idiopathic Neonatal Hepatitis

Background: The two most common and important causes of neonatal cholestasis (NC) are biliary atresia (BA) and Idiopathic neonatal hepatitis (INH). There is no single test that can definitely differentiate these two entities. Objective: To evaluate the diagnostic accuracy of clinical and laboratory parameters for diagnosis of biliary atresia. Methods: This cross-sectional study was conducted at the department of Pediatric Gastroenterology and Nutrition of Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, from August 2013 through July 2015 among purposively sampled infants with neonatal cholestasis. Results: Total 86 neonatal cholestatic cases were studied. Term baby and good birth weight are significantly higher in BA cases. The presence of persistent pale colored stool is significantly more in patients with BA (p 0.000). GGT is the only liver enzyme that was found to be useful differentiating BA from INH at a cut-off value ≥ 524U/L or 9.5 times higher than upper limit normal with sensitivity and specificity of 81.6% and 72.9% respectively. In the present study the diagnostic accuracy of persistent pale colored stool found to be highest (79.1 %). Conclusion: The present study showed that Persistent pale colored stool and serum level of GGT with a cut-off value ≥524 U/L or 9.5 times higher than upper limit normal can be considered as predictive markers for differentiation of Biliary atresia from Idiopathic neonatal hepatitis. CBMJ 2015 January: Vol. 04 No. 01 P: 30-36

ERRATUM

PEDIATRICS ◽  
1992 ◽  
Vol 89 (6) ◽  
pp. 1131-1131
Keyword(s):  
Case Reports ◽  
Identical Twin ◽  
Dna Fingerprint ◽  
Neonatal Hepatitis ◽  
Idiopathic Neonatal Hepatitis

In the article, "Idiopathic Neonatal Hepatitis in One DNA Fingerprint Identical Twin'" by Vajro et al(Pediatrics.1992;2:329-330) there is an error unde"Case Reports." Instead of "At age 13 weeks the infant had acholic stools . . .," it should read "At age 3 weeks . . ." In addition, under "Discussion," the fourth paragraph should read, "Our case reports show that, as observed previously in EHBA also in INH the responsible initiating event may affect only one identical twin."

The role of CK7, Ki-67, CD34 and vimentin in the differentiation between biliary atresia and idiopathic neonatal hepatitis in Egyptian cholestatic neonates

Apmis ◽  
2012 ◽  
Vol 120 (7) ◽  
pp. 529-538 ◽  
Author(s):  
HAYAM ABDEL SAMIE AIAD ◽  
MONA ABDEL HALIM KANDIL ◽  
REHAB MONIR SAMAKA ◽  
MERVAT MAHMOUD SULTAN ◽  
MOHAMED TAWFIK BADR ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Neonatal Hepatitis ◽  
Ki 67 ◽  
Idiopathic Neonatal Hepatitis

scholarly journals Neonatal hepatitis and extrahepatic biliary atresia in the same sibship.

1981 ◽  
Vol 133 (4) ◽  
pp. 445-450 ◽  
Author(s):  
JUNKO SUDA ◽  
SHUNICHI NAKAJIMA ◽  
MARIKO OKANIWA ◽  
SHIGEHIKO KAMOSHITA
Keyword(s):  
Biliary Atresia ◽  
Neonatal Hepatitis ◽  
Extrahepatic Biliary Atresia

scholarly journals CD 56 staining in liver biopsies does not help in differentiating extrahepatic biliary atresia from other causes of neonatal cholestasis

2008 ◽  
Vol 3 (1) ◽  
pp. 10 ◽  
Author(s):  
Fatemeh E Mahjoub ◽  
Reza Khairkhah ◽  
Mehri Sani ◽  
Guiti Irvanloo ◽  
Maryam Monajemzadeh
Keyword(s):  
Biliary Atresia ◽  
Neonatal Cholestasis ◽  
Extrahepatic Biliary Atresia ◽  
Liver Biopsies
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