Relationship between testosterone binding globulin and the failure of androgens to suppress serum gonadotropin concentrations in long-term castrated adult male rhesus monkeys (Macaca mulatta)

1981 ◽  
Vol 14 (11) ◽  
pp. 1223-1227 ◽  
Author(s):  
Stephen J. Winters ◽  
Philip Troen ◽  
Tony M. Plant
2015 ◽  
Vol 78 (1) ◽  
pp. 152-166 ◽  
Author(s):  
Matthew J. Kessler ◽  
Qian Wang ◽  
Antonietta M. Cerroni ◽  
Marc D. Grynpas ◽  
Olga D. Gonzalez Velez ◽  
...  

1997 ◽  
Vol 272 (5) ◽  
pp. E901-E907 ◽  
Author(s):  
J. J. Ramsey ◽  
E. B. Roecker ◽  
R. Weindruch ◽  
J. W. Kemnitz

Energy expenditure, activity, and body composition were measured in 30 adult male rhesus monkeys used in a study having the long-term goal of determining the effects of moderate dietary restriction (DR) on aging. All animals were fed a defined diet, with the restricted animals maintained at approximately 70% of the caloric intakes of the controls. After 12 mo of DR, body fat mass of restricted monkeys was 33% less than that of controls (P = 0.004), whereas lean body mass differences were not present until after 24 mo. At the 24- and 30-mo assessments, nighttime energy expenditure was significantly reduced (P < 0.01) in the restricted compared with control monkeys after adjustment for lean body mass differences, whereas morning, afternoon, and total energy expenditure were not significantly different (P > 0.05). No significant differences (P > 0.05) in activity were noticed between treatment groups at any time point. DR resulted in a prolonged decrease in resting energy expenditure, which could contribute to the possible life-extending action of this treatment.


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