Energy expenditure of adult male rhesus monkeys during the first 30 mo of dietary restriction

1997 ◽  
Vol 272 (5) ◽  
pp. E901-E907 ◽  
Author(s):  
J. J. Ramsey ◽  
E. B. Roecker ◽  
R. Weindruch ◽  
J. W. Kemnitz
Keyword(s):  
Energy Expenditure ◽  
Lean Body Mass ◽  
Body Mass ◽  
Dietary Restriction ◽  
Adult Male ◽  
Rhesus Monkeys ◽  
Resting Energy Expenditure ◽  
Treatment Groups ◽  
Male Rhesus

Energy expenditure, activity, and body composition were measured in 30 adult male rhesus monkeys used in a study having the long-term goal of determining the effects of moderate dietary restriction (DR) on aging. All animals were fed a defined diet, with the restricted animals maintained at approximately 70% of the caloric intakes of the controls. After 12 mo of DR, body fat mass of restricted monkeys was 33% less than that of controls (P = 0.004), whereas lean body mass differences were not present until after 24 mo. At the 24- and 30-mo assessments, nighttime energy expenditure was significantly reduced (P < 0.01) in the restricted compared with control monkeys after adjustment for lean body mass differences, whereas morning, afternoon, and total energy expenditure were not significantly different (P > 0.05). No significant differences (P > 0.05) in activity were noticed between treatment groups at any time point. DR resulted in a prolonged decrease in resting energy expenditure, which could contribute to the possible life-extending action of this treatment.

Dietary Restriction of Adult Male Rhesus Monkeys: Design, Methodology, and Preliminary Findings From the First Year of Study

1993 ◽  
Vol 48 (1) ◽  
pp. B17-B26 ◽  
Author(s):  
J. W. Kemnitz ◽  
R. Weindruch ◽  
E. B. Roecker ◽  
K. Crawford ◽  
P. L. Kaufman ◽  
...  
Keyword(s):  
Dietary Restriction ◽  
Adult Male ◽  
Rhesus Monkeys ◽  
Design Methodology ◽  
First Year ◽  
Male Rhesus

scholarly journals Dietary Restriction and Beta-Cell Sensitivity to Glucose in Adult Male Rhesus Monkeys

2003 ◽  
Vol 58 (7) ◽  
pp. B598-B610 ◽  
Author(s):  
T. A. Gresl ◽  
R. J. Colman ◽  
T. C. Havighurst ◽  
D. B. Allison ◽  
D. A. Schoeller ◽  
...  
Keyword(s):  
Beta Cell ◽  
Dietary Restriction ◽  
Adult Male ◽  
Rhesus Monkeys ◽  
Cell Sensitivity ◽  
Male Rhesus

scholarly journals Energy expenditure and body composition in children with Crohn’s disease: effect of enteral nutrition and treatment with prednisolone

Gut ◽  
1997 ◽  
Vol 41 (2) ◽  
pp. 203-208 ◽  
Author(s):  
M Azcue ◽  
M Rashid ◽  
A Griffiths ◽  
P B Pencharz
Keyword(s):  
Body Composition ◽  
Anorexia Nervosa ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Energy Expenditure ◽  
Enteral Nutrition ◽  
Lean Body Mass ◽  
Body Mass ◽  
Resting Energy Expenditure ◽  
Body Compartments

Background—Malnutrition and growth retardation are common complications of Crohn’s disease in children. The contribution of resting energy expenditure (REE) to malnutrition is unclear.Aims—To characterise the REE and body composition in children with Crohn’s disease and compare them with normal controls and patients with anorexia nervosa; to compare the effects of prednisolone and enteral nutrition on energy expenditure and body composition.Subjects—Twenty four children with Crohn’s disease, 19 malnourished females with anorexia nervosa, and 22 healthy control subjects were studied.Methods—In children with Crohn’s disease measurements were done when the disease was acute and repeated at one and three months after treatment with either prednisolone or enteral nutrition. Resting energy expenditure was measured by indirect calorimetry and body composition by anthropometry, bioelectrical impedance analysis, total body potassium, H218O, and bromide space studies.Results—Body weight and ideal body weight were significantly lower in patients with Crohn’s disease than in healthy controls. Lean tissue was depleted and there was an increase in extracellular water. Per unit of lean body mass, there was no difference between REE in patients with Crohn’s disease and controls, whereas patients with anorexia nervosa had significantly reduced REE. With enteral nutrition all body compartments and REE increased significantly (p<0.001). In a subgroup of age-matched men there was a significant increase in height after three months of enteral nutrition compared with prednisolone (p<0.01). Those treated with steroids did not show a significant change in height but did show an increase in all body compartments. However, intracellular water as well as lean body mass accretion were significantly higher in the enteral nutrition group than in the prednisolone group.Conclusions—Despite being malnourished, children with Crohn’s disease fail to adapt their REE per unit of lean body mass. This might be a factor contributing to their malnutrition. Lean tissue accretion is higher in patients treated with enteral nutrition than in those treated with prednisolone.

scholarly journals No consistent evidence of a disproportionately low resting energy expenditure in long-term successful weight-loss maintainers

2018 ◽  
Vol 108 (4) ◽  
pp. 658-666 ◽  
Author(s):  
Danielle M Ostendorf ◽  
Edward L Melanson ◽  
Ann E Caldwell ◽  
Seth A Creasy ◽  
Zhaoxing Pan ◽  
...  
Keyword(s):  
Weight Loss ◽  
Energy Expenditure ◽  
Body Mass ◽  
Resting Energy Expenditure ◽  
Weight Loss Maintenance ◽  
Fat Free Mass ◽  
Predictive Equations ◽  
Successful Weight Loss ◽  
Resting Energy

Abstract Background Evidence in humans is equivocal in regards to whether resting energy expenditure (REE) decreases to a greater extent than predicted for the loss of body mass with weight loss, and whether this disproportionate decrease in REE persists with weight-loss maintenance. Objectives We aimed to1) determine if a lower-than-predicted REE is present in a sample of successful weight-loss maintainers (WLMs) and 2) determine if amount of weight loss or duration of weight-loss maintenance are correlated with a lower-than-predicted REE in WLMs. Design Participants (18–65 y old) were recruited in 3 groups: WLMs (maintaining ≥13.6 kg weight loss for ≥1 y, n = 34), normal-weight controls [NCs, body mass index (BMI; in kg/m2) similar to current BMI of WLMs, n = 35], and controls with overweight/obesity (OCs, BMI similar to pre–weight-loss maximum BMI of WLMs, n = 33). REE was measured (REEm) with indirect calorimetry. Predicted REE (REEp) was determined via 1) a best-fit linear regression developed with the use of REEm, age, sex, fat-free mass, and fat mass from our control groups and 2) three standard predictive equations. Results REEm in WLMs was accurately predicted by equations developed from NCs and OCs (±1%) and by 3 standard predictive equations (±3%). In WLMs, individual differences between REEm and REEp ranged from −257 to +163 kcal/d. A lower REEm compared with REEp was correlated with amount of weight lost (r = 0.36, P < 0.05) but was not correlated with duration of weight-loss maintenance (r = 0.04, P = 0.81). Conclusions We found no consistent evidence of a significantly lower REE than predicted in a sample of long-term WLMs based on predictive equations developed from NCs and OCs as well as 3 standard predictive equations. Results suggest that sustained weight loss may not always result in a substantial, disproportionately low REE. This trial was registered at clinicaltrials.gov as NCT03422380.

Regional lean body mass and resting energy expenditure in non-obese adults

2001 ◽  
Vol 40 (3) ◽  
pp. 93-97 ◽  
Author(s):  
Manfred J. Müller ◽  
Kirsten Illner ◽  
Anja Bosy-Westphal ◽  
Gisbert Brinkmann ◽  
Martin Heller
Keyword(s):  
Energy Expenditure ◽  
Lean Body Mass ◽  
Body Mass ◽  
Resting Energy Expenditure ◽  
Obese Adults ◽  
Resting Energy

Resting Energy Expenditure in Peritoneal Dialysis Patients

2006 ◽  
Vol 26 (6) ◽  
pp. 697-704 ◽  
Author(s):  
Ana P. Bazanelli ◽  
Maria A. Kamimura ◽  
Camila Barbosa da Silva ◽  
Carla M. Avesani ◽  
Miriam G. Garcia Lopes ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Energy Expenditure ◽  
Lean Body Mass ◽  
Body Mass ◽  
Body Fat ◽  
Resting Energy Expenditure ◽  
Healthy Individuals ◽  
Female Patients ◽  
Male Patients ◽  
And Gender

Objectives This study aimed to evaluate whether resting energy expenditure (REE) of patients undergoing peritoneal dialysis (PD) therapy differs from that of healthy individuals, as well as to investigate the factors associated with REE in this sample of patients. Design Cross-sectional study. Setting Dialysis Unit of the Nephrology Division, Federal University of Sao Paulo–Oswaldo Ramos Foundation, Brazil. Subjects and Methods The study examined the REE of 37 patients (20 males, age 44.5 ± 13 years) undergoing PD therapy. Only patients older than 18 years, on PD for at least 3 months, without catabolic illness, and with normal thyroid function were included. Patients were pair matched for age and gender with 37 healthy individuals. REE was measured by indirect calorimetry. Body composition was assessed by dual-energy x-ray absorptiometry in the patients and by bioelectrical impedance in the healthy individuals. Results The REE of PD patients was similar to that of pair-matched controls (1372 ± 266 and 1453 ± 252 kcal/day respectively, p = 0.13) even when adjusted for lean body mass and gender ( p = 0.56). The REE of PD patients was positively correlated with lean body mass ( r = 0.60, p < 0.01), fat mass ( r = 0.43, p < 0.01), body mass index (r = 0.60, p < 0.01), serum glucose (r = 0.36, p < 0.05), and protein equivalent of nitrogen appearance (PNA; r = 0.42, p < 0.01). There were no correlations between REE and glucose absorption, dialysis-related parameters, C-reactive protein, and energy or protein intake by 3-day food diary. In the multiple linear regression analysis, using REE as the dependent variable, the final model showed that lean body mass and female gender were determinants of REE in PD patients ( R2 = 0.44). When separate analysis by gender was performed, REE correlated directly with body fat in female patients (r = 0.70, p < 0.01) but not in male patients ( r = 0.29, p = 0.21). On the other hand, lean body mass was significantly correlated with REE in male patients ( r = 0.78, p < 0.01) but not in female patients ( r = 0.47, p = 0.06). Conclusions This study showed that REE of PD patients did not differ from that of healthy individuals. The strong association between body fat and REE in female patients remains to be further investigated.

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