Effects of dietary protein on urinary calcium in normal subjects and in patients with nephrolithiasis

Metabolism ◽  
1979 ◽  
Vol 28 (9) ◽  
pp. 895-900 ◽  
Author(s):  
Angelo A. Licata ◽  
Ernestina Bou ◽  
Frederic C. Bartter ◽  
James Cox
Keyword(s):  
Dietary Protein ◽  
Normal Subjects ◽  
Urinary Calcium

THE DEPENDENCE OF URINARY CALCIUM AND OTHER ELECTROLYTES ON ADRENAL FUNCTION DURING ACUTE SODIUM DEPLETION AND LOADING

1970 ◽  
Vol 64 (1) ◽  
pp. 65-74 ◽  
Author(s):  
Lars Runeberg ◽  
B.-A. Lamberg ◽  
P. Reissell ◽  
H. Adlercreutz
Keyword(s):  
Sodium Excretion ◽  
Extracellular Volume ◽  
Normal Subjects ◽  
Urinary Calcium ◽  
Calcium Excretion ◽  
Minor Importance ◽  
Sodium Depletion ◽  
Sodium Loading ◽  
Urinary Potassium ◽  
Normal Controls

ABSTRACT The time course of the renal excretion of calcium, magnesium, sodium, and potassium during sodium depletion and the rapid correction of the extracellular volume deficit was studied in normal subjects and in patients with Addison's disease (AD). The decrease in body weight was similar in the two groups, but the haematocrit value increased more in the patients with AD. Sodium depletion suppressed sodium excretion much more efficiently in normal controls than in the AD patients. Calcium excretion was roughly equally depressed in two groups. During sodium loading there was an immediate increase in renal sodium excretion in the patients with AD, whereas the sodium-retaining state generally continued for about one day in the normal controls. Urinary potassium decreased gradually during the first day of sodium loading in the normal controls but not in the AD patients. In the normal subjects calcium excretion remained low during the first day and increased on the second day of sodium loading. In the AD patients there was a gradual increase in urinary calcium during the first day of sodium loading, which did not, however, parallel the changes in urinary sodium content in individual urine samples. Urinary magnesium did not change significantly. It is concluded that the effect of adrenal steroids on renal calcium excretion is of minor importance. They may, however, to some extent induce calcium retention.

Does Dietary Protein Increase Urinary Calcium?

1991 ◽  
Vol 121 (1) ◽  
pp. 151-151
Author(s):  
Herta Spencer ◽  
Lois Kramer
Keyword(s):  
Dietary Protein ◽  
Urinary Calcium

The Measurement of Intestinal Calcium Absorption by External Radioisotope Counting: Application to Study of Nephrolithiasis

1970 ◽  
Vol 39 (1) ◽  
pp. 95-106 ◽  
Author(s):  
M. R. Wills ◽  
E. Zisman ◽  
J. Wortsman ◽  
R. G. Evens ◽  
C. Y. C. Pak ◽  
...  
Keyword(s):  
Calcium Absorption ◽  
Scintillation Counter ◽  
Renal Stones ◽  
Normal Subjects ◽  
Total Radioactivity ◽  
Urinary Calcium ◽  
Intestinal Calcium Absorption ◽  
Absolute Amount ◽  
Calcium Load ◽  
Fractional Calcium Absorption

1. Gastro-intestinal absorption of calcium was studied in man by the measurement of forearm radioactivity in a large-volume liquid scintillation counter following separate oral and intravenous doses of 47CaCl2. From the ratio of the percentages of total radioactivity appearing in the forearm following these separate determinations the fractional absorption of calcium was estimated. 2. Changes of forearm radioactivity with time following the administration of this isotope were studied; evidence is presented that the radioactivity in the forearm at 4 h after administration of the isotope gives a valid assessment of fractional calcium absorption. 3. Fractional calcium absorption determined by this technique correlated well with the net calcium absorption as determined from stool radioactivity after oral administration of isotope. 4. In normal subjects it was shown that fractional calcium absorption measured by this technique varies inversely with the stable calcium load and that the absolute amount of calcium absorbed from given loads increases with the size of the load in the range 20–1000 mg calcium. 5. Gastro-intestinal calcium absorption was measured at various oral calcium loads in a group of fifteen patients with recurrent calcium-containing renal stones. All the patients were normocalcaemic; some had hypercalciuria. In the patients with hypercalciuria, calcium absorption, fractional and absolute, was significantly increased at all calcium loads as compared to that of patients with normal urinary calcium. 6. It is concluded that hyperabsorption of calcium from the gastro-intestinal tract plays a crucial role in the aetiology of hypercalciuria, probably by causing an increase in the renal filtered calcium load.

scholarly journals Effects of Dietary Protein Levels on Kidney and Urinary Calcium in Female Rats.

1994 ◽  
Vol 47 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Shoji AZAMI ◽  
Shizuko HIRATSUKA ◽  
Takao KITANO ◽  
Takatoshi ESASHI
Keyword(s):  
Dietary Protein ◽  
Urinary Calcium ◽  
Female Rats ◽  
Protein Levels

scholarly journals Protein absorption and ammonia production: the effects of dietary protein and removal of the colon

1976 ◽  
Vol 35 (1) ◽  
pp. 61-65 ◽  
Author(s):  
J. A. Gibson ◽  
G. E. Sladen ◽  
A. M. Dawson
Keyword(s):  
Protein Content ◽  
Dietary Protein ◽  
Significant Variation ◽  
Normal Subjects ◽  
Ammonia Production ◽  
Rectal Anastomosis ◽  
N Content ◽  
Protein Absorption ◽  
Faecal Nitrogen

1. The effect of increasing dietary protein content on the amount of faecal nitrogen was measured in six normal subjects and five subjects without functioning colons (three with ileostomy and two with ileo-rectal anastomosis).2. There was a significant increase in the amount of faecal N with increased dietary protein content in the subjects without functioning colons.3. In normal subjects with intact colons, faecal N content was found to be lower than that in subjects without colons, and furthermore there was no significant variation with diet.4. The source of the increase in faecal N with increased dietary protein content in subjects without functioning colons is discussed and the significance of these findings in relation to the efficiency of protein absorption is considered.

EFFECT OF DEXAMETHASONE ON CALCIUM METABOLISM AND 47Ca KINETICS IN NORMAL SUBJECTS

1969 ◽  
Vol 61 (1) ◽  
pp. 173-192 ◽  
Author(s):  
Bernardo Léo Wajchenberg ◽  
Virgilio Gonçalves Pereira ◽  
Julio Kieffer ◽  
Silvio Ursic
Keyword(s):  
Direct Effect ◽  
Calcium Metabolism ◽  
Kinetic Studies ◽  
Compartmental Analysis ◽  
Active Phase ◽  
Normal Subjects ◽  
Intestinal Wall ◽  
Urinary Calcium ◽  
Calcium Excretion ◽  
Mucosal Cell

ABSTRACT The effects of pharmacological doses of dexamethasone on calcium metabolism were evaluated in 4 normal subjects, by stable calcium and phosphorus balances and 47Ca kinetic studies. The radioactivity data were satisfactorily fitted to a model with 2 exchanging compartments. There was a significant increase in urinary calcium excretion rate with higher specific activities. The total faecal calcium did not alter despite changes in its components, i. e. a fall in endogenous faecal calcium and an increase in unabsorbed dietary calcium. The data suggest that dexamethasone inhibits the rate of calcium transfer across the intestinal wall. more intensely from the mucosal cell to the lumen (secretion). From the constants of compartmental analysis, the only significant and consistent change was the increase in bone resorption rate. Bone deposition rate increased in 2 and decreased in the remaining 2 subjects. The results of our studies indicate that dexamethasone has a direct effect on the way calcium is dealt with by the kidney and the gut and that the drug has a direct effect on the skeleton. For comparison a patient with Cushing's syndrome was studied during the active phase and also after clinical and laboratorial remission of the disease.

Dietary Protein Increases Urinary Calcium

1990 ◽  
Vol 120 (1) ◽  
pp. 134-136 ◽  
Author(s):  
Jane E. Kerstetter ◽  
Lindsay H. Allen
Keyword(s):  
Dietary Protein ◽  
Urinary Calcium
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