Mechanism of the plasma cholesterol lowering effect of tazasubrate in rats: Accelerated plasma cholesterol transport with increased liver lipoprotein receptor activity

1986 ◽  
Vol 18 (3) ◽  
pp. 203-216 ◽  
Author(s):  
H.W. Diekmann ◽  
H. Sailer ◽  
A. Garbe ◽  
H. Nowak ◽  
M.R. Lovati ◽  
...  
Keyword(s):  
Plasma Cholesterol ◽  
Receptor Activity ◽  
Cholesterol Transport ◽  
Lipoprotein Receptor ◽  
Cholesterol Lowering ◽  
Lowering Effect ◽  
Cholesterol Lowering Effect

scholarly journals Cholesterol-lowering effect of soyabean lecithin in normolipidaemic rats by stimulation of biliary lipid secretion

1996 ◽  
Vol 75 (3) ◽  
pp. 471-481 ◽  
Author(s):  
Elisabeth Polichetti ◽  
Nicolas Diaconescu ◽  
Paulette Lechene De La Porte ◽  
Lina Malli ◽  
Henri Portugal ◽  
...  
Keyword(s):  
Plasma Cholesterol ◽  
Hdl Cholesterol ◽  
Biliary Lipid ◽  
Total Lipids ◽  
High Fat ◽  
Cholesterol Lowering ◽  
Lowering Effect ◽  
Low Fat Diet ◽  
Fat Diets ◽  
Cholesterol Lowering Effect

AbstractThe purpose of the present study was to assess the role of the liver in the plasma-cholesterol-lowering effect of soyabean lecithin. Normolipidaemic rats were fed on lecithin-enriched or control diets with the same amount of protein. The lecithin diets contained 200 g/kg high-fat commercial semi-purified soyabean lecithin (230 g/kg total lipids as soyabean phosphatidylcholine) or 200 g/kg high-fat purified soyabean lecithin (930 g/kg total lipids as soyabean phosphatidylcholine). The control diets were a low-fat diet (40 g fat/kg) and a high-fat triacylglycerol-rich diet (200 g fat/kg). The high-fat diets were isoenergetic. The cholesterol-lowering effect of the lecithin-enriched diets was associated with significantly lower levels of plasma total- and HDL-cholesterol and significantly higher levels of bile phosphatidylcholine (PC), bile salts and cholesterol. These findings suggest that the liver plays a major role in the reduction of plasma cholesterol, the increased biliary lipid being provided by both HDL and the hepatic microsomal pools of PC and cholesterol.

scholarly journals Rosuvastatin Reduces Atherosclerosis Development Beyond and Independent of Its Plasma Cholesterol–Lowering Effect in APOE*3-Leiden Transgenic Mice

Circulation ◽  
2003 ◽  
Vol 108 (11) ◽  
pp. 1368-1374 ◽  
Author(s):  
Robert Kleemann ◽  
Hans M.G. Princen ◽  
Jef J. Emeis ◽  
J. Wouter Jukema ◽  
Ruud D. Fontijn ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Plasma Cholesterol ◽  
Cholesterol Lowering ◽  
Lowering Effect ◽  
Atherosclerosis Development ◽  
Cholesterol Lowering Effect
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