The structure of a cyclic peptide toxin, cyanogenosin-rr from microcystis aeruginosa

1988 ◽  
Vol 29 (1) ◽  
pp. 11-14 ◽  
Author(s):  
Prabha Painuly ◽  
Ricardo Perez ◽  
Toshio Fukai ◽  
Yuzuru Shimizu
Keyword(s):  
Microcystis Aeruginosa ◽  
Cyclic Peptide ◽  
Peptide Toxin

Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice

Toxicology ◽  
2003 ◽  
Vol 188 (2-3) ◽  
pp. 285-296 ◽  
Author(s):  
Nidhi Gupta ◽  
S.C. Pant ◽  
R. Vijayaraghavan ◽  
P.V.Lakshmana Rao
Keyword(s):  
Cyclic Peptide ◽  
Toxicity Evaluation ◽  
Comparative Toxicity ◽  
Peptide Toxin

Injury to hepatocytes induced by a peptide toxin from the cyanobacterium Microcystis aeruginosa

Toxicon ◽  
1987 ◽  
Vol 25 (11) ◽  
pp. 1235-1239 ◽  
Author(s):  
Maria T.C. Runnegar ◽  
Joanne Andrews ◽  
Robert G. Gerdes ◽  
Ian R. Falconer
Keyword(s):  
Microcystis Aeruginosa ◽  
Peptide Toxin

Enzymatic pathway for the bacterial degradation of the cyanobacterial cyclic peptide toxin microcystin LR.

1996 ◽  
Vol 62 (11) ◽  
pp. 4086-4094 ◽  
Author(s):  
D G Bourne ◽  
G J Jones ◽  
R L Blakeley ◽  
A Jones ◽  
A P Negri ◽  
...  
Keyword(s):  
Cyclic Peptide ◽  
Bacterial Degradation ◽  
Peptide Toxin

Rapid microfilament reorganization induced in isolated rat hepatocytes by microcystin-LR, a cyclic peptide toxin

1989 ◽  
Vol 185 (1) ◽  
pp. 86-100 ◽  
Author(s):  
J.E. Eriksson ◽  
G.I.L. Paatero ◽  
J.A.O. Meriluoto ◽  
G.A. Codd ◽  
G.E.N. Kass ◽  
...  
Keyword(s):  
Cyclic Peptide ◽  
Rat Hepatocytes ◽  
Isolated Rat Hepatocytes ◽  
Peptide Toxin ◽  
Isolated Rat

scholarly journals Chemical Study of the Hepatotoxins from Microcystis Aeruginosa Collected in California

1993 ◽  
Vol 5 (3) ◽  
pp. 409-412 ◽  
Author(s):  
S. E. DeVries ◽  
M. Namikoshi ◽  
F. D. Galey ◽  
J. E. Merritt ◽  
K. L. Rinehart ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Microcystis Aeruginosa ◽  
High Performance ◽  
Fast Atom Bombardment ◽  
Cyclic Peptide ◽  
Algal Cell ◽  
Chemical Study ◽  
Blue Green Alga ◽  
Peptide Toxins ◽  
Layer Chromatography

Four cyclic peptide toxins were purified and quantified from the aqueous extract of algal cell material utilizing high performance liquid chromatography, thin layer chromatography, and fast atom bombardment mass spectrometry. The cyclic peptide toxins appear to be similar structurally to hepatotoxins Iron previously identified blooms of the blue-green alga Microcystis aeruginosa.

ISOLATION AND IDENTIFICATION OF THE FAST-DEATH FACTOR IN MICROCYSTIS AERUGINOSA NRC-1

1959 ◽  
Vol 37 (1) ◽  
pp. 453-471 ◽  
Author(s):  
C. T. Bishop ◽  
E. F. L. J. Anet ◽  
P. R. Gorham
Keyword(s):  
Amino Acids ◽  
Molecular Weight ◽  
Body Weight ◽  
Microcystis Aeruginosa ◽  
Sodium Salt ◽  
Cyclic Peptide ◽  
Isolation And Identification ◽  
Toxic Compound ◽  
Molar Ratios ◽  
Crude Preparation

The fast-death factor in Microcystis aeruginosa NRC-1 is an acidic, probably cyclic peptide containing the following amino acids in the molar ratios indicated: L-aspartic (1); L-glutamic (2); D-serine (1); L-valine (1); L-ornithine (1); L-alanine (2); L-leucine (2). It is possible, although not likely, that one of the residues of glutamic, alanine, or leucine also is in the D-configuration. The toxin, in the form of its sodium salt, was extracted from lyophilized algal cells by water, separated from pigments by extraction into n-butanol, and freed from high-molecular-weight impurities by dialysis. No separation of a single toxic compound could be obtained by countercurrent distribution, chromatography, or electrophoresis in carbonate, acetate, or phosphate buffers. Electrophoresis of the crude toxin on cellulose in 0.1 M borate yielded five peptides one of which was toxic and accounted for 100% of the toxicity present in the crude preparation. The intraperitoneal LD50of the pure toxin for mice was 0.466 ± 0.013 mg/kg body weight.

Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR

1992 ◽  
Vol 118 (6) ◽  
pp. 420-424 ◽  
Author(s):  
Rie Nishiwaki-Matsushima ◽  
Tetsuya Ohta ◽  
Shinji Nishiwaki ◽  
Masami Suganuma ◽  
Kiyomi Kohyama ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Cyclic Peptide ◽  
Tumor Promotion ◽  
Peptide Toxin
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