Interferon-mediated inhibition of mouse mammary tumor virus expression in cultured cells

Virology ◽  
1977 ◽  
Vol 82 (1) ◽  
pp. 232-236 ◽  
Author(s):  
James A. Strauchen ◽  
Nathaniel A. Young ◽  
Robert M. Friedman
Keyword(s):  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Cultured Cells ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Virus Expression

scholarly journals Interleukin-4 Up-Regulates Mouse Mammary Tumor Virus Expression yet Is Not Required for In Vivo Virus Spread

2001 ◽  
Vol 75 (23) ◽  
pp. 11886-11890 ◽  
Author(s):  
Jennifer Czarneski ◽  
Jennifer Meyers ◽  
Tao Peng ◽  
Valsamma Abraham ◽  
Rosemarie Mick ◽  
...  
Keyword(s):  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Interleukin 4 ◽  
Mammary Tissue ◽  
Virus Spread ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Virus Expression

ABSTRACT The mouse mammary tumor virus (MMTV) superantigen induces T-cell production of cytokines, such as interleukin-4, which in turn increase MMTV transcription. However, interleukin-4 is not required for in vivo virus spread, because mice lacking interleukin-4 or the STAT6 transcription factor showed wild-type infection of lymphoid and mammary tissue. In spite of this, mammary tumor incidence was decreased in STAT6 null mice.

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