Mouse Mammary Tumor Virus Expression and Mammary Tumor Development

1983 ◽  
pp. 57-78 ◽  
Author(s):  
Rob Michalides ◽  
Albert Van Ooyen ◽  
Roeland Nusse
Keyword(s):  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Tumor Development ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Virus Expression

Interferon-mediated inhibition of mouse mammary tumor virus expression in cultured cells

Virology ◽  
1977 ◽  
Vol 82 (1) ◽  
pp. 232-236 ◽  
Author(s):  
James A. Strauchen ◽  
Nathaniel A. Young ◽  
Robert M. Friedman
Keyword(s):  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Cultured Cells ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Virus Expression

scholarly journals Interleukin-4 Up-Regulates Mouse Mammary Tumor Virus Expression yet Is Not Required for In Vivo Virus Spread

2001 ◽  
Vol 75 (23) ◽  
pp. 11886-11890 ◽  
Author(s):  
Jennifer Czarneski ◽  
Jennifer Meyers ◽  
Tao Peng ◽  
Valsamma Abraham ◽  
Rosemarie Mick ◽  
...  
Keyword(s):  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Interleukin 4 ◽  
Mammary Tissue ◽  
Virus Spread ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Virus Expression

ABSTRACT The mouse mammary tumor virus (MMTV) superantigen induces T-cell production of cytokines, such as interleukin-4, which in turn increase MMTV transcription. However, interleukin-4 is not required for in vivo virus spread, because mice lacking interleukin-4 or the STAT6 transcription factor showed wild-type infection of lymphoid and mammary tissue. In spite of this, mammary tumor incidence was decreased in STAT6 null mice.

scholarly journals A Novel Mechanism of Resistance to Mouse Mammary Tumor Virus Infection

2000 ◽  
Vol 74 (6) ◽  
pp. 2752-2759 ◽  
Author(s):  
Tatyana V. Golovkina
Keyword(s):  
Mammary Gland ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Inbred Mice ◽  
Tumor Development ◽  
Mammary Glands ◽  
Mammary Tissue ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus

ABSTRACT Exogenous mouse mammary tumor virus (MMTV) is carried from the gut of suckling pups to the mammary glands by lymphocytes and induces mammary gland tumors. MMTV-induced tumor incidence in inbred mice of different strains ranges from 0 to as high as 100%. For example, mice of the C3H/HeN strain are highly susceptible, whereas mice of the I/LnJ strain are highly resistant. Of the different factors that together determine the susceptibility of mice to development of MMTV-induced mammary tumors, genetic elements play a major role, although very few genes that determine a susceptibility-resistance phenotype have been identified so far. Our data indicate that MMTV fails to infect mammary glands in I/LnJ mice foster nursed on viremic C3H/HeN females, even though the I/LnJ mammary tissue is not refractory to MMTV infection. Lymphocytes from fostered I/LnJ mice contained integrated MMTV proviruses and shed virus but failed to establish infection in the mammary glands of susceptible syngeneic (I × C3H.JK)F1 females. Based on the susceptible-resistant phenotype distribution in N2 females, both MMTV mammary gland infection and mammary gland tumor development in I/LnJ mice are controlled by a single locus.

scholarly journals The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice

2018 ◽  
Vol 188 (2) ◽  
pp. 515-524 ◽  
Author(s):  
Amanda S. Peretti ◽  
Dayna Dominguez ◽  
Martha M. Grimes ◽  
Helen J. Hathaway ◽  
Eric R. Prossnitz ◽  
...  
Keyword(s):  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Tumor Development ◽  
T Antigen ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Polyoma Middle T Antigen ◽  
Middle T Antigen
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