Antigenic determinants of influenza virus hemagglutinin XII. The epitopes of a synthetic peptide representing the C-terminus of HA1

Virology ◽  
1986 ◽  
Vol 155 (2) ◽  
pp. 625-632 ◽  
Author(s):  
David C. Jackson ◽  
Xi-Lin Tang ◽  
Lorena E. Brown ◽  
Julie M. Murray ◽  
David O. White ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Synthetic Peptide ◽  
Antigenic Determinants ◽  
C Terminus ◽  
Influenza Virus Hemagglutinin

scholarly journals Idiotypy of clonal responses to influenza virus hemagglutinin.

1981 ◽  
Vol 154 (5) ◽  
pp. 1525-1538 ◽  
Author(s):  
Y N Liu ◽  
C A Bona ◽  
J L Schulman
Keyword(s):  
Influenza Virus ◽  
Monoclonal Antibodies ◽  
Binding Sites ◽  
Cross Reactivity ◽  
Secondary Response ◽  
Antigenic Determinants ◽  
Antiviral Responses ◽  
Influenza Virus Hemagglutinin ◽  
The Cross

Anti-idiotype antisera were raised in syngeneic (BALB/c mice) and homologous (A/J mice) systems to study the cross-reactive idiotypes among monoclonal antibodies to PR8 and B/Lee virus HA and the expression of these idiotypes during primary and secondary antiviral responses of BALB/c mice. Extensive idiotypic cross-reactivity was demonstrated among monoclonal antibodies specific for distinct antigenic determinants on PR8 hemagglutinin (HA). The study of idiotypy of monoclonal antibodies against the same or overlapping antigenic determinants on B/Lee HA showed that these monoclonal antibodies may bear (a) a true individual idiotype not shared by other monoclonal antibodies, (b) idiotypes shared by few monoclonal antibodies, and (c) true cross-reactive idiotypes shared by all of these monoclonal antibodies. In contrast, no cross-reactive idiotypes were detectable among monoclonal antibodies to B/Lee HA and monoclonal antibodies to PR8 HA. Furthermore, we have shown that the anti-idiotype antibodies we used recognize determinants on monoclonal antibodies closely associated with antigenic binding sites. Finally, studies of the idiotypes expressed during primary and secondary antiviral HA responses of mice immunized with B/Lee virus revealed persistence of some idiotypes during both primary and secondary responses, whereas others were only expressed in the primary or secondary response.

scholarly journals ANTIBODY RESPONSES TO ANTIGENIC DETERMINANTS OF INFLUENZA VIRUS HEMAGGLUTININ

1974 ◽  
Vol 140 (6) ◽  
pp. 1571-1578 ◽  
Author(s):  
Jean-Louis Virelizier ◽  
Anthony C. Allison ◽  
Geoffrey C. Schild
Keyword(s):  
Influenza Virus ◽  
Antibody Responses ◽  
Secondary Response ◽  
Antigenic Determinants ◽  
Memory Cells ◽  
Spleen Cells ◽  
Experimental Conditions ◽  
Influenza Virus Hemagglutinin ◽  
Kinetics Of ◽  
Antibody Secretion

Mice immunized sequentially with two related influenza virus hemagglutinins (HA) produced a secondary antibody response with two different specificities. Some antibodies were specific for determinants common to both HA's. Paradoxically, some antibodies were directed to determinants existing only in the HA first encountered. Primed spleen cells treated with anti-θ serum and complement were transferred from animals immunized with the first HA to either normal, irradiated, or thymus-deprived recipients. These memory cells were boosted in the recipients with either the homologous or the heterologous cross-reacting HA. B-memory lymphocytes were shown to be directly triggered by both HA's and to be able to secrete, independently of T lymphocytes, antibodies to both kinds of determinants. However, T cells were shown to modulate this secondary response by either enhancing or suppressing antibody secretion by B-memory cells, depending on experimental conditions. These results are discussed in terms of antigen recognition by B cells and of kinetics of development of immunological memory.

Glycosylation of a Synthetic Peptide Representing a T-Cell Determinant of Influenza Virus Hemagglutinin Results in Loss of Recognition by CD4+ T-Cell Clones

Virology ◽  
1994 ◽  
Vol 199 (2) ◽  
pp. 422-430 ◽  
Author(s):  
David C. Jackson ◽  
Heidi E. Drummer ◽  
Laszlo Urge ◽  
Laszlo Otvos ◽  
Lorena E. Brown
Keyword(s):  
Influenza Virus ◽  
T Cell ◽  
Synthetic Peptide ◽  
Cd4 T Cell ◽  
T Cell Clones ◽  
Influenza Virus Hemagglutinin ◽  
Cell Clones

scholarly journals Antigenic determinants in influenza virus hemagglutinin.

1979 ◽  
Vol 24 (3) ◽  
pp. 804-807 ◽  
Author(s):  
Z I Rovnova ◽  
P N Kosyakov ◽  
O N Berezina ◽  
E I Isayeva ◽  
V M Zhdanov
Keyword(s):  
Influenza Virus ◽  
Antigenic Determinants ◽  
Influenza Virus Hemagglutinin
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