The nucleotide sequence of the gene encoding the newcastle disease virus membrane protein and comparisons of membrane protein sequences

Virology ◽  
1987 ◽  
Vol 156 (2) ◽  
pp. 221-228 ◽  
Author(s):  
L McGinnes
1986 ◽  
Vol 14 (22) ◽  
pp. 9051-9061 ◽  
Author(s):  
Philip Chambers ◽  
Neil S. Millar ◽  
Simon G. Platt ◽  
Peter T. Emmerson

2001 ◽  
Vol 82 (7) ◽  
pp. 1729-1736 ◽  
Author(s):  
Zhuhui Huang ◽  
Sateesh Krishnamurthy ◽  
Aruna Panda ◽  
Siba K. Samal

A previous report showed that insertion of a foreign gene encoding chloramphenicol acetyltransferase (CAT) between the HN and L genes of the full-length cDNA of a virulent Newcastle disease virus (NDV) yielded virus with growth retardation and attenuation. The NDV vector used in that study was pathogenic to chickens; it is therefore not suitable for use as a vaccine vector. In the present study, an avirulent NDV vector was generated and its potential to express CAT protein was evaluated. The CAT gene was under the control of NDV transcriptional start and stop signals and was inserted immediately before the open reading frame of the viral 3′-proximal nucleocapsid protein gene. A recombinant NDV expressing CAT activity at a high level was recovered. The replication and pathogenesis of the CAT-expressing recombinant NDV were not modified significantly. These results indicate the potential utility of an avirulent NDV as a vaccine vector.


Virology ◽  
1988 ◽  
Vol 165 (1) ◽  
pp. 291-295 ◽  
Author(s):  
Ulrike M. Schaper ◽  
Frederick J. Fuller ◽  
Marsha D.W. Ward ◽  
Yasmin Mehrotra ◽  
Henry O. Stone ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document