Identification of an epitope encoded in the env gene of friend murine leukemia virus recognized by anti-friend virus cytotoxic T lymphocytes

Virology ◽  
1991 ◽  
Vol 181 (1) ◽  
pp. 91-100 ◽  
Author(s):  
Ke-San Ruan ◽  
Frank Lilly
Keyword(s):  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Friend Virus ◽  
Murine Leukemia

scholarly journals Specificity studies on cytolytic T lymphocytes directed against murine leukemia virus-induced tumors. Analysis of monoclonal cytolytic T lymphocytes.

1982 ◽  
Vol 155 (4) ◽  
pp. 1050-1062 ◽  
Author(s):  
F Plata
Keyword(s):  
T Lymphocytes ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Target Cells ◽  
Cytolytic T Lymphocytes ◽  
Tumor Target ◽  
Induced Tumors ◽  
Definition Of ◽  
Leukemia Viruses ◽  
Murine Leukemia

The specificities of cloned cytolytic T lymphocytes (CTL) were studied for the analysis of CTL populations generated against murine leukemia viruses (MuLV) in H-2 congenic BALB/c (H-2d) and BALB.B (H-2b) mice. In particular, CTL generated in response to tumors induced by Gross MuLV and Friend MuLV were studied; these tumors expressed virus-induced antigens that do not cross-react and that can be distinguished from each other. The systematic study of 92 CTL clones clearly indicated that MuLV-immune CTL were highly heterogeneous with respect to both the intensities of target cell lysis that they mediated and to their specificity of recognition of MuLV-induced tumor target cells. Various categories of CTL clones were identified, ranging from CTL clones tht were tightly H-2 restricted and specific for the immunizing tumor to CTL clones that displayed no discernible patterns of specificity and that attacked a large number of different target cells. In addition, the surface markers of these cloned CTL were defined, and the best conditions for their prolonged maintenance in culture were determined. The present data indicate that future efforts in the definition of target antigens recognized by tumor-specific CTL should be performed with monoclonal lymphocytes.

Spontaneous Regression of Friend Virus-Induced Erythroleukemia. II. Regression of Friend Murine Leukemia Virus-Induced Lymphocytic Leukemia2

1977 ◽  
Vol 59 (3) ◽  
pp. 957-961 ◽  
Author(s):  
Michael Dietz ◽  
Clifford Longley ◽  
Susan P. Fouchey ◽  
LaVonne Hall ◽  
Marvin A. Rich ◽  
...  
Keyword(s):  
Murine Leukemia Virus ◽  
Spontaneous Regression ◽  
Leukemia Virus ◽  
Friend Virus ◽  
Murine Leukemia

scholarly journals Thymic targets for Abelson murine leukemia virus are early gamma/delta T lymphocytes.

1991 ◽  
Vol 88 (9) ◽  
pp. 3700-3704 ◽  
Author(s):  
G. D. Holland ◽  
K. Ito ◽  
D. A. Kaehler ◽  
S. Tonegawa ◽  
R. Risser
Keyword(s):  
T Lymphocytes ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Gamma Delta ◽  
Abelson Murine Leukemia Virus ◽  
Murine Leukemia
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