Spontaneous Regression of Friend Virus-Induced Erythroleukemia. II. Regression of Friend Murine Leukemia Virus-Induced Lymphocytic Leukemia2

1977 ◽  
Vol 59 (3) ◽  
pp. 957-961 ◽  
Author(s):  
Michael Dietz ◽  
Clifford Longley ◽  
Susan P. Fouchey ◽  
LaVonne Hall ◽  
Marvin A. Rich ◽  
...  
Keyword(s):  
Murine Leukemia Virus ◽  
Spontaneous Regression ◽  
Leukemia Virus ◽  
Friend Virus ◽  
Murine Leukemia

scholarly journals A new gene that controls the type of leukemia induced by Friend murine leukemia virus.

1983 ◽  
Vol 158 (2) ◽  
pp. 493-505 ◽  
Author(s):  
J E Silver ◽  
T N Fredrickson
Keyword(s):  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Dominant Gene ◽  
Helper Virus ◽  
Single Dominant Gene ◽  
Friend Virus ◽  
C57bl Mice ◽  
New Gene ◽  
Murine Leukemia

NB tropic Friend murine leukemia virus (F-MuLV) replicates equally well in BALB/c and C57BL mice inoculated as neonates but causes almost exclusively erythroblastosis in BALB/c mice and nonerythroid (lymphoid and myelogenous) leukemias in C57BL mice. The C57BL resistance to erythroblastosis appears to be controlled by a single dominant gene in first and second backcrosses to BALB/c. This resistance to erythroblastosis is distinct from other genes known to affect susceptibility to Friend virus including Fv-1, Fv-2, H-2, Rfv-3, Fv-4, and Rmcf. We suggest the name Fhe for the new gene controlling susceptibility to Friend helper virus erythroblastosis.

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