Calculations of intrinsic isotope effects and the detection of tunneling in enzyme-catalyzed reactions

Bioorganic Chemistry ◽

10.1016/0045-2068(90)90026-2 ◽

1990 ◽

Vol 18 (4) ◽

pp. 435-439 ◽

Author(s):

Dexter B. Northrop ◽

Ronald G. Duggleby

Keyword(s):

Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

Download Full-text

Multiple Isotope Effects on Enzyme-Catalyzed Reactions

Annual Review of Biochemistry ◽

10.1146/annurev.bi.58.070189.002113 ◽

1989 ◽

Vol 58 (1) ◽

pp. 377-401 ◽

Author(s):

M H O'Leary

Keyword(s):

Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

Download Full-text

Isotope effects on enzyme-catalyzed reactions

Current Biology ◽

10.1016/0960-9822(92)90030-e ◽

1992 ◽

Vol 2 (10) ◽

pp. 548

Author(s):

Vernon E. Anderson

Keyword(s):

Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

Download Full-text

Calculation of substrate dissociation constants from steady-state isotope effects in enzyme-catalyzed reactions

Journal of the American Chemical Society ◽

10.1021/ja00290a052 ◽

1985 ◽

Vol 107 (4) ◽

pp. 1058-1060 ◽

Author(s):

Judith P. Klinman ◽

Rowena G. Matthews

Keyword(s):

Steady State ◽

Dissociation Constants ◽

Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

Download Full-text

Primary and secondary deuterium isotope effects on equilibrium constants for enzyme-catalyzed reactions

Biochemistry ◽

10.1021/bi00562a023 ◽

1980 ◽

Vol 19 (21) ◽

pp. 4853-4858 ◽

Author(s):

Paul F. Cook ◽

John S. Blanchard ◽

W. W. Cleland

Keyword(s):

Isotope Effects ◽

Equilibrium Constants ◽

Deuterium Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

Download Full-text

pH Variation of isotope effects in enzyme-catalyzed reactions. 2. Isotope-dependent step not pH dependent. Kinetic mechanism of alcohol dehydrogenase

Biochemistry ◽

10.1021/bi00510a015 ◽

1981 ◽

Vol 20 (7) ◽

pp. 1805-1816 ◽

Author(s):

Paul F. Cook ◽

W. W. Cleland

Keyword(s):

Alcohol Dehydrogenase ◽

Isotope Effects ◽

Kinetic Mechanism ◽

Ph Variation ◽

Ph Dependent ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

Download Full-text

[4] Determination of heavy-aton isotope effects on enzyme-catalyzed reactions

Methods in Enzymology - Enzyme Kinetics and Mechanism - Part B: Isotopic Probes and Complex Enzyme Systems ◽

10.1016/s0076-6879(80)64006-3 ◽

1980 ◽

pp. 83-104 ◽

Author(s):

Marion H. O'Leary

Keyword(s):

Isotope Effects ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

Download Full-text

The expression of kinetic isotope effects during the time course of enzyme-catalyzed reactions

Bioorganic Chemistry ◽

10.1016/0045-2068(89)90018-7 ◽

1989 ◽

Vol 17 (2) ◽

pp. 177-193 ◽

Author(s):

Ronald G. Duggleby ◽

Dexter B. Northrop

Keyword(s):

Time Course ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Kinetic Isotope ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

Download Full-text

Substrate and pH Dependence of Isotope Effects in Enzyme Catalyzed Reactions

Isotope Effects In Chemistry and Biology ◽

10.1201/9781420028027.ch30 ◽

2005 ◽

pp. 793-810 ◽

Author(s):

Paul Cook ◽

William Karsten

Keyword(s):

Isotope Effects ◽

Ph Dependence ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

Download Full-text

The Application of Transient-State Kinetic Isotope Effects to the Resolution of Mechanisms of Enzyme-Catalyzed Reactions

Molecules ◽

10.3390/molecules18078230 ◽

2013 ◽

Vol 18 (7) ◽

pp. 8230-8242 ◽

Author(s):

Harvey Fisher

Keyword(s):

Isotope Effects ◽

Transient State ◽

Kinetic Isotope Effects ◽

Kinetic Isotope ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions ◽

Download Full-text

CHAPTER 21. Molecular Dynamics Simulation of Kinetic Isotope Effects in Enzyme-Catalyzed Reactions

Theoretical and Computational Chemistry Series - Reaction Rate Constant Computations ◽

10.1039/9781849737753-00530 ◽

2013 ◽

pp. 530-549

Author(s):

Jiali Gao

Keyword(s):

Molecular Dynamics ◽

Molecular Dynamics Simulation ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Dynamics Simulation ◽

Kinetic Isotope ◽

Catalyzed Reactions ◽

Enzyme Catalyzed Reactions

Download Full-text