scholarly journals Senescence in vitro and ionising radiations—the human diploid fibroblast model

1981 ◽  
Vol 15 (1) ◽  
pp. 51-63 ◽  
Author(s):  
A.F.G. Stevenson ◽  
T. Cremer
Keyword(s):  
Human Diploid Fibroblast ◽  
Diploid Fibroblast ◽  
Ionising Radiations ◽  
Fibroblast Model

scholarly journals The Cultured Diploid Fibroblast as a Model for the Study of Cellular Aging

1992 ◽  
Vol 3 (4) ◽  
pp. 353-370 ◽  
Author(s):  
Thomas H. Norwood ◽  
William R. Pendergrass
Keyword(s):  
Culture System ◽  
Proliferative Activity ◽  
Cellular Level ◽  
Cellular Aging ◽  
Pivotal Role ◽  
Proliferative Potential ◽  
Human Diploid Fibroblast ◽  
Diploid Fibroblast

The limited proliferative potential of the cultured human diploid fibroblast is now well established. A number of biological correlates suggest that this culture system is a model for the study of aging at the cellular level. The mechanism(s) that causes the loss of proliferative activity is unknown; the results of some recent studies indicate that specific genes may play a pivotal role in cellular aging in vitro. The extent to which changes in proliferative functions are causally related to aging in vivo is currently under investigation.

scholarly journals Senescence Delay of Human Diploid Fibroblast Induced by Anti-sense p16INK4aExpression

2001 ◽  
Vol 276 (51) ◽  
pp. 48325-48331 ◽  
Author(s):  
Jianming Duan ◽  
Zongyu Zhang ◽  
Tanjun Tong
Keyword(s):  
Human Diploid Fibroblast ◽  
Diploid Fibroblast
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