β-Methasone increases neonatal sepsis Simpson G, Harbert G: Use of β-methasone in management of preterm gestation with premature rupture of membranes. OBSTET GYNECOL 66:168, 1985

1986 ◽  
Vol 31 (2) ◽  
pp. 109
Keyword(s):  
Neonatal Sepsis ◽  
Obstet Gynecol ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture

Different Management Strategies for Term Newborns Delivered with Premature rupture of membranes

2021 ◽  
Vol 15 (6) ◽  
pp. 1423-1425
Author(s):  
J. Zain ◽  
M. Asim ◽  
K. Firdos ◽  
T. Laique
Keyword(s):  
Treatment Group ◽  
Neonatal Sepsis ◽  
Controlled Trial ◽  
Full Term ◽  
Ethical Review ◽  
Large Sample Size ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Insignificant Difference ◽  
Term Newborns

Background: Premature rupture of membranes (PROM) is a leading cause of neonatal morbidity and mortality. Aim: To compare the outcomes of prophylactic versus selective antibiotics in term newborns born after PROM > 18 hours in terms of neonatal sepsis and resistance of neonatal. Study design: Randomized controlled trial. Methodology: This study enrolled (n=120) asymptomatic term (37+ weeks) babies of either gender with PROM > 18 hours after ethical review committee’s (ERC) approval. This study held at DHQ Hospital, Rawalpindi-Pakistan in 2019. Data was collected through a structured proforma with informed consent. Data was analyzed by SPSS, v-20. The study outcomes were neonatal sepsis and resistant neonatal flora. Chi-square test was applied with p≤0.05 taken as significant. Results: The neonatal sepsis was diagnosed in 8 (13.3%) and 9(15%) babies in the prophylactic treatment group and the selective treatment group, respectively having statistically insignificant difference (p>0.05). Likewise, resistant neonatal flora between both groups showed statistically insignificant difference (p>0.05). Conclusion: We concluded that there was insignificant difference in terms of rates of neonatal sepsis and resistant neonatal flora between two treatment groups. However, there is a need to conduct large sample size, multicentre studies to validate these results before making recommendations for routine treatment of full term babies with PROM >18 hours in our clinical settings. Keywords: Neonates, Premature Rupture Of Membranes, Full Term, Neonatal Sepsis and Resistant Neonatal Flora.

scholarly journals Effect of antibiotics on inflammatory marker (IL-6) and perinatal outcomes in women with preterm premature rupture of membranes

2018 ◽  
Vol 7 (10) ◽  
pp. 4068
Author(s):  
Ashima Arora ◽  
Ratna Biswas ◽  
Bhawna Dubey ◽  
Binita Goswami ◽  
Sonal Saxena
Keyword(s):  
Neonatal Sepsis ◽  
Neonatal Intensive Care ◽  
Inflammatory Marker ◽  
Perinatal Outcomes ◽  
Admission Rate ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Adverse Perinatal Outcomes ◽  
High Level

Background: The aim is to study the effect of antibiotics on inflammatory marker (IL-6) and perinatal outcomes in women with preterm premature rupture of membranes (PPROM).Methods: 60 women with PPROM at 28–34 weeks of gestation were enrolled in the study. All the women were given antibiotics as per hospital protocol and were subjected to blood sampling for Interleukin -6(IL-6) at admission, delivery and umbilical cord blood. IL-6 levels were assessed for associations with adverse perinatal outcomes and the effect of antibiotic treatment on IL-6 and perinatal outcomes were studied. The data were analyzed using t test and χ2 test.Results: Increased level of IL-6 was associated with chorioamnionitis and neonatal sepsis (p<0.001). High level of IL-6 led to early delivery and complete course of antibiotics suppressed IL-6 (p<0.001) and clinical chorioamnionitis in women with PROM. Full course of antibiotics also decreased the admission rate of babies to neonatal intensive care unit and suppressed respiratory distress syndrome, neonatal sepsis.Conclusions: Increased level of IL-6 is seen in women with chorioamnionitis and neonatal sepsis. Antibiotics suppress the IL-6 levels, chorioamnionitis and neonatal sepsis.

scholarly journals Low Vitamin D Levels Increase the Risk of Early Onset Neonatal Sepsis

2020 ◽  
pp. 87-91
Author(s):  
Lisnawati Yuyun ◽  
Ali Sungkar ◽  
Rinawati Rohsiswatno ◽  
Noroyono Wibowo ◽  
Denni Hermartin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Umbilical Cord ◽  
Neonatal Sepsis ◽  
Medical Records ◽  
Early Onset ◽  
Study Data ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Vitamin D Levels

Abstract Objective: To identify the association between maternal and umbilical cord vitamin D levels with suspects of early-onset of neonatal sepsis (EONS) in newborns from mothers with preterm premature rupture of membranes (PPROM).Methods: This is a retrospective cohort study conducted from January 2017 to Augusts 2018. Data was taken consecutively from medical records and previous study data at Dr. Cipto Mangunkusumo and Persahabatan Hospital, Jakarta.Results: From total of 72 infants from mothers with PPROM, 22 infants (31%) were EONS-suspected and 50 infants (69%) were not EONS-suspected. There was a significant association between maternal and umbilical cord vitamin D levels with EONS.Conclusion: There was a significant association between maternal and umbilical cord vitamin D levels with EONS.Keywords: early-onset neonatal sepsis, preterm premature rupture of membrane, vitamin D,   Abstrak Tujuan: Untuk mengetahui hubungan antara kadar vitamin D maternal dan tali pusat dengan risiko tejadinya Sepsis Neonatal Awitan Dini (SNAD) pada bayi dari ibu dengan Ketuban Pecah Dini (KPD).Metode: Desain penelitian kohort retrospektif secara consecutive sampling. Data diambil dari rekam medis dan data penelitian sebelumnya di Rumah Sakit Umum Pusat Nasional (RSUPN) Dr. Cipto Mangunkusumo dan Rumah Sakit Umum Pusat (RSUP) Persahabatan, Jakarta. Hasil:  Dari 72 bayi yang dilahirkan dari ibu dengan KPD, 22 bayi (31%) diantaranya diduga mengalami SNAD, sedangkan 50 bayi lainnya tidak mengalami SNAD. Terdapat hubungan yang bermakna antara kadar vitamin D maternal dan tali pusat dengan kejadian SNAD. Kesimpulan:Terdapathubungan yang bermakna antara kadar vitamin D maternal dan tali pusat dengan kejadian SNAD.Kata kunci: ketuban pecah dini,  sepsis neonatal awitan dini, vitamin D

Risk of Neonatal Sepsis with Rescue Steroids in Preterm Premature Rupture of Membranes versus Intact Membranes [25F]

2018 ◽  
Vol 131 ◽  
pp. 70S
Author(s):  
Emily E. TenBrink ◽  
Angela Quain ◽  
Joanne Daggy ◽  
David Michael Haas ◽  
Anthony Shanks
Keyword(s):  
Neonatal Sepsis ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture

Can neonatal sepsis be predicted in late preterm premature rupture of membranes? Development of a prediction model

2014 ◽  
Vol 176 ◽  
pp. 90-95 ◽  
Author(s):  
David P. van der Ham ◽  
Sander van Kuijk ◽  
Brent C. Opmeer ◽  
Christine Willekes ◽  
Johannes J. van Beek ◽  
...  
Keyword(s):  
Prediction Model ◽  
Neonatal Sepsis ◽  
Late Preterm ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture

scholarly journals Faktor Risiko Ibu Dalam Meningkatkan Kejadian Sepsis Neonatorum Di RSUD Dr. H. Moch. Ansari Saleh Banjarmasin

2019 ◽  
pp. 73-83
Author(s):  
Fitri Yuliana ◽  
Mahpolah Mahpolah ◽  
Eriza Nopariyanti
Keyword(s):  
Risk Factors ◽  
Gestational Age ◽  
Neonatal Sepsis ◽  
Case Control ◽  
Maternal Risk Factors ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Maternal Risk ◽  
Purposive Sampling ◽  
Prolonged Labor

Latar Belakang: Penyebab utama kematian bayi baru lahir atau neonatal di dunia antara lain bayi lahir premature 29%, sepsis dan pneumonia 25% dan 23% merupakan bayi baru lahir dengan asfiksia dan trauma. Sepsis neonatorum merupakan salah satu penyakit infeksi yang dapat menyebabkan kematian pada bayi baru lahir, angka kejadian sepsis di Indonesia masih tinggi yaitu 8,7% sampai 30,29% dengan angka kematian 11,56% sampai 49,9%.  Kejadian sepsis neonatorum di RSUD dr. H. Moch. Ansari Saleh pada tahun 2014 sebanyak 2,9%, tahun 2015 sebanyak 1,2%, dan tahun 2016 sebanyak 1,2%.Tujuan: Menganalisis faktor risiko ibu dalam meningkatkan kejadian sepsis neonatorum di RSUD Dr. H. Moch. Ansari Saleh Tahun 2017.Metode: Penelitian kuantitatif dengan rancangan case control. Populasi penelitian ini adalah semua bayi baru lahir yang tercatat di rekam medik RSUD dr. H. Moch Ansari Saleh tahun 2017 sebanyak 4516 orang. Sampel kasus diambil dengan total sampling sebanyak 55 orang sedangkan sampel kontrol diambil dengan teknik purposive sampling sebanyak 55 orang. Data dianalisis menggunakan uji chi-square.Hasil: Faktor risiko ibu yang terjadi selama kehamilan terbukti dapat meningkatkan kejadian sepsis neonatorum yaitu persalinan lama (ρ=0,032 a=0,05), ketuban pecah dini (ρ=0,015 a=0,05), dan usia kehamilan (ρ=0,022 a=0,05). Dari ketiga faktor tersebut ibu yang mengalami ketuban pecah dini merupakan faktor yang paling berisiko menyebabkan sepsis neonatorum dibandingkan dengan yang tidak mengalami ketuban pecah dini (OR = 2,571) sedangkan faktor risiko ibu yang tidak berhubungan adalah infeksi antepartum dan komplikasi kehamilan.Simpulan: Dari lima faktor risiko ibu terdapat tiga faktor yang dapat meningkatkan kejadian sepsis neonatorum yaitu faktor yang paling beresiko adalah ketuban pecah dini dan faktor lainnya adalah persalinan lama dan usia kehamilan. Kata Kunci: Ketuban pecah dini, Persalinan lama, Sepsis neonatorum, Usia kehamilan Mother Risk Factors In Increasing The Incidence Of Neonatal Sepsis At Dr. H. Moch. Ansari Saleh Hospital Of BanjarmasinABSTRACT  Background: The main causes of newborn or neonatal deaths in the world include premature babies 29%, sepsis and pneumonia 25% and 23% are newborns with asphyxia and trauma. Neonatal sepsis is one of the infectious diseases that can cause death in newborns, the incidence of sepsis in Indonesia is still high at 8.7% to 30.29% with a mortality rate of 11.56% to 49.9%. The incidence of Neonatal Sepsis at Dr. H. Moch. Ansari Saleh Hospital of Banjarmasin in 2014 as much as 2.9%, in 2015 as many as 1.2%, and in 2016 as many as 1.2%.Objective: To analyzing maternal risk factors in increasing the incidence of neonatal sepsis at Dr. H. Moch. Ansari Saleh Hospital of Banjarmasin in 2017.Methods: Quantitative research with case control design. The study population was all newborns recorded in the medical record at Dr. H. Moch. Ansari Saleh Hospital of Banjarmasin in 2017 as many as 4516 people. Case samples were taken with a total sampling of 55 people while the control samples were taken with a purposive sampling technique of 55 people. Data were analyzed using the chi-square test.Results: Maternal risk factors that occur during pregnancy have been shown to increase the incidence of neonatal sepsis, prolonged labor (ρ=0,032 a=0,05), premature rupture of membranes (ρ=0,015 a=0,05), and gestational age (ρ=0,022 a=0,05). Of the three factors, mothers who experienced premature rupture of membranes were the most at risk for causing neonatal sepsis compared with those who did not experience premature rupture of membranes (OR = 2,571) while unrelated maternal risk factors were antepartum infection and pregnancy complications.Conclusion: Of the five maternal risk factors there are three factors that can increase the incidence of neonatal sepsis, which is the most risky factor is premature rupture of the membranes and other factors are prolonged labor and gestational age.  Key Words: Gestational age, Neonatal sepsis, Premature rupture of membranes, Prolonged labor  

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