Role of dopamine and GABA in the control of motor activity elicited from the rat nucleus accumbens

1991 ◽  
Vol 38 (4) ◽  
pp. 829-835 ◽  
Author(s):  
Lisa S. Wong ◽  
Galia Eshel ◽  
Jakub Dreher ◽  
Jenny Ong ◽  
David M. Jackson
1999 ◽  
Vol 19 (10) ◽  
pp. 4123-4131 ◽  
Author(s):  
Louk J. M. J. Vanderschuren ◽  
George Wardeh ◽  
Taco J. De Vries ◽  
Arie H. Mulder ◽  
Anton N. M. Schoffelmeer

1993 ◽  
Vol 31 (5) ◽  
pp. 621-625 ◽  
Author(s):  
Milagros Méndez ◽  
Julio Morán ◽  
Sherwin Wilk ◽  
Patricia Joseph-Bravo ◽  
Jean-Louis Charli

2001 ◽  
Vol 281 (4) ◽  
pp. R1232-R1242 ◽  
Author(s):  
Brian A. Baldo ◽  
Ann E. Kelley

Amylin, a calcitonin gene-related peptide-like peptide coreleased with insulin, exerts anorexic effects on central administration. Because previous studies revealed dense amylin binding in the nucleus accumbens (Acb), we investigated the behavioral effects of amylin infusions (10, 30, and 100 ng/side) into Acb subregions. Intra-Acb shell amylin infusions decreased ambulation, rearing, feeding, and drinking in either food-deprived rats or water-deprived rats; motor activity was affected more potently than ingestive behavior. Moreover, intra-Acb shell amylin reduced motor activity in nondeprived rats tested in the absence of food or water, indicating that the expression of amylin's effects is independent of drive or proximal incentives. Intra-Acb core amylin infusions in water-deprived rats also decreased ambulation and water intake, although anterior Acb placements were associated with smaller motor effects, regardless of Acb subregion. In contrast to amylin's effects, intra-Acb shell infusions of orexin-A (50, 100, and 500 ng/side) had no effects on motor activity, feeding, or drinking. Hence the Acb may be a target for behavioral regulation by satiety-related peptides like amylin.


2010 ◽  
Vol 68 ◽  
pp. e422
Author(s):  
Shigenobu Toda ◽  
Sakurako Kosugi ◽  
Hao-wei Shen ◽  
Yoshio Iguchi ◽  
Tetsu Hirosawa ◽  
...  

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