Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids III. Efficacy and safety of unfractionated and high-molecular-weight preparations in rhinoconjunctivitis and asthma

1989 ◽  
Vol 84 (4) ◽  
pp. 546-556 ◽  
Author(s):  
J BOUSQUET ◽  
H MAASCH ◽  
A HEJJAOUI ◽  
W SKASSABROCIEK ◽  
R WAHL ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Grass Pollen ◽  
Efficacy And Safety ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Mixed Grass

Double-Blind, Placebo-Controlled Immunotherapy with a High-Molecular-Weight, Formalinized Allergoid in Grass Pollen Allergy

1987 ◽  
Vol 82 (3-4) ◽  
pp. 550-552 ◽  
Author(s):  
Jean Bousquet ◽  
Edda Frank ◽  
Michel Soussana ◽  
Adnan Hejjaoui ◽  
Hans J. Maasch ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Grass Pollen ◽  
Pollen Allergy ◽  
Grass Pollen Allergy ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Acute and Short-term Chronic Testosterone Fluctuation Effects on Glucose Homeostasis, Insulin Sensitivity, and Adiponectin: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

2014 ◽  
Vol 99 (6) ◽  
pp. E1088-E1096 ◽  
Author(s):  
Christian Høst ◽  
Lars C. Gormsen ◽  
David M. Hougaard ◽  
Jens S. Christiansen ◽  
Steen B. Pedersen ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Glucose Metabolism ◽  
Crossover Study ◽  
High Molecular Weight ◽  
Glucose Disposal ◽  
Short Term ◽  
High Molecular Weight Adiponectin ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Total Glucose

Context: Low levels of adiponectin and T in men have been shown to predict development of the metabolic syndrome, but the effects of T on glucose metabolism are incompletely understood and may be influenced either directly or indirectly through changes in body composition or in levels of adiponectin. Objective: The aim of the study was to test whether T exerts its effects on glucose metabolism directly or indirectly. Design, Setting, and Participants: In a randomized, double-blind, placebo-controlled, crossover study, 12 healthy young males were studied on four separate occasions. They received GnRH agonist treatment 1 month before 3 of 4 trial days to induce castrate levels of T. On trial days, T gel containing either high or low physiological T dose or placebo was applied to the body. On a fourth trial day, participants constituted their own eugonadal controls. Intervention: Each study comprised a 5-hour basal period and a 3-hour hyperinsulinemic euglycemic clamp. Main Outcome Measures: We measured the effect of acute T on peripheral glucose disposal, total adiponectin and subforms, and other indices of glucose metabolism. Results: Short-term hypogonadism was associated with increased high molecular weight adiponectin levels (P < .03) and increased oxidative glucose disposal (P = .03) but not total glucose disposal (P = .07). Acute T treatment was an independent suppressor of high molecular weight adiponectin levels (P = .04) but did not affect total glucose disposal (P = .17). Conclusions: These data show that T can act through putative fast nongenomic pathways to affect adiponectin levels in humans. The early hypogonadal state is characterized by a marked shift in fuel oxidation from lipids toward glucose, which may rely partly on buffering capabilities of adiponectin.

Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids

1990 ◽  
Vol 85 (2) ◽  
pp. 490-497 ◽  
Author(s):  
J. Bousquet ◽  
A. Hejjaoui ◽  
M. Soussana ◽  
F-B. Michel
Keyword(s):  
Grass Pollen ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Mixed Grass
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