Substance P, calcitonin gene-related peptide, and vasoactive intestinal peptide increase in nasal secretions after allergen challenge in atopic patients

1993 ◽  
Vol 92 (1) ◽  
pp. 95-104 ◽  
Author(s):  
B MOSIMANN ◽  
M WHITE ◽  
R HOHMAN ◽  
M GOLDRICH ◽  
H KAULBACH ◽  
...  
Keyword(s):  
Substance P ◽  
Vasoactive Intestinal Peptide ◽  
Allergen Challenge ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Nasal Secretions

Effects of the three neuropeptides, vasoactive intestinal peptide, substance P, and calcitonin gene related peptide on basal and stimulated calcitonin release in the rat

1987 ◽  
Vol 115 (3) ◽  
pp. 297-300 ◽  
Author(s):  
B. Månsson ◽  
B. Ahrén ◽  
A. Nobin
Keyword(s):  
Substance P ◽  
Vasoactive Intestinal Peptide ◽  
Calcium Chloride ◽  
Single Injection ◽  
Peak Plasma ◽  
Calcitonin Gene Related Peptide ◽  
C Cells ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Calcitonin Secretion

Abstract. Calcitonin is secreted from the thyroidal C-cells. Except that calcitonin secretion is stimulated by calcium, little is known of its regulation. Vasoactive intestinal peptide (VIP), substance P, and calcitonin gene related peptide (CGRP) have recently been detected within intrathyroidal neurons, and CGRP also within the C-cells, and may therefore affect calcitonin secretion. In this study, we investigated whether VIP, substance P or CGRP could influence calcitonin secretion in the rat. Each of these peptides was administered as a single injection (1.5 nmol/animal) or as a 30-min infusion (1.5 nmol/animal per 30 min) during which calcium chloride, 456 μmol/animal, was injected iv. We found that the peptides had no effect on basal calcitonin secretion, but that VIP potentiated the calcium-induced calcitonin release. Thus, the peak plasma calcitonin level following calcium chloride injection was doubled by the infusion of VIP (P < 0.001). In contrast, neither substance P nor CGRP significantly influenced the calcium-induced calcitonin release. We conclude that VIP, a neuropeptide within intrathyroidal nerves, has the capacity to augment calcium-induced calcitonin secretion in the rat and we therefore suggest that VIP is a regulator of calcitonin secretion.

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