On the Role of Substance P, Galanin, Vasoactive Intestinal Peptide, and Calcitonin Gene?related Peptide in Mediation of Spinal Reflex Excitability in Rats with Intact and Sectioned Peripheral Nerves

1991 ◽  
Vol 632 (1 Substance P a) ◽  
pp. 198-211 ◽  
Author(s):  
Z. WIESENFELD-HALLIN ◽  
X-J. XU ◽  
R. HÅKANSON ◽  
D. M. FENG ◽  
K. FOLKERS ◽  
...  
Keyword(s):  
Substance P ◽  
Vasoactive Intestinal Peptide ◽  
Peripheral Nerves ◽  
Calcitonin Gene Related Peptide ◽  
Spinal Reflex ◽  
Reflex Excitability ◽  
Related Peptide ◽  
Calcitonin Gene

Plasma Changes of Calcitonin Gene-Related Peptide and Substance P in Patients with Dialysis Headache

Cephalalgia ◽  
2006 ◽  
Vol 26 (11) ◽  
pp. 1287-1293 ◽  
Author(s):  
M Alessandri ◽  
L Massanti ◽  
P Geppetti ◽  
G Bellucci ◽  
M Cipriani ◽  
...  
Keyword(s):  
Substance P ◽  
Plasma Concentrations ◽  
Calcitonin Gene Related Peptide ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Biochemical Factor ◽  
Before And After ◽  
Basal Plasma ◽  
Headache Patients

Little is known of mechanism of dialysis headache (DH). As suggested for migraine, a role for neuropeptides has been investigated. Twenty-four patients under haemodialysis were studied. Twelve of them suffered from DH. The remaining patients were headache free. Blood samples for radioimmunoassay of calcitonin gene-related peptide (CGRP) and substance P (SP) were collected from the arteriovenous fistula before and after dialysis treatment. Basal plasma concentrations of CGRP were found to be higher in headache patients. Dialysis significantly decreased CGRP concentrations in both groups. No difference in basal plasma concentrations of SP was observed between groups. At the end of the treatment plasma SP concentrations were reduced in headache-free patients but increased in headache patients. Elevated plasma concentrations of CGRP in patients with DH could represent a biochemical factor contributing to susceptibility to headache. Because of the disputable role of SP in migraine, the significance of the increase of the peptide in plasma during DH remains to be elucidated.

Effects of the three neuropeptides, vasoactive intestinal peptide, substance P, and calcitonin gene related peptide on basal and stimulated calcitonin release in the rat

1987 ◽  
Vol 115 (3) ◽  
pp. 297-300 ◽  
Author(s):  
B. Månsson ◽  
B. Ahrén ◽  
A. Nobin
Keyword(s):  
Substance P ◽  
Vasoactive Intestinal Peptide ◽  
Calcium Chloride ◽  
Single Injection ◽  
Peak Plasma ◽  
Calcitonin Gene Related Peptide ◽  
C Cells ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Calcitonin Secretion

Abstract. Calcitonin is secreted from the thyroidal C-cells. Except that calcitonin secretion is stimulated by calcium, little is known of its regulation. Vasoactive intestinal peptide (VIP), substance P, and calcitonin gene related peptide (CGRP) have recently been detected within intrathyroidal neurons, and CGRP also within the C-cells, and may therefore affect calcitonin secretion. In this study, we investigated whether VIP, substance P or CGRP could influence calcitonin secretion in the rat. Each of these peptides was administered as a single injection (1.5 nmol/animal) or as a 30-min infusion (1.5 nmol/animal per 30 min) during which calcium chloride, 456 μmol/animal, was injected iv. We found that the peptides had no effect on basal calcitonin secretion, but that VIP potentiated the calcium-induced calcitonin release. Thus, the peak plasma calcitonin level following calcium chloride injection was doubled by the infusion of VIP (P < 0.001). In contrast, neither substance P nor CGRP significantly influenced the calcium-induced calcitonin release. We conclude that VIP, a neuropeptide within intrathyroidal nerves, has the capacity to augment calcium-induced calcitonin secretion in the rat and we therefore suggest that VIP is a regulator of calcitonin secretion.

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