Prevalence of maternal HIV infection in Scotland based on unlinked anonymous testing of newborn babies

The Lancet ◽  
1991 ◽  
Vol 337 (8757) ◽  
pp. 1565-1567 ◽  
Author(s):  
F. Cockburn ◽  
D.M. Tappin ◽  
R.W.A. Girdwood ◽  
R. Kennedy ◽  
A.J. Brown ◽  
...  
1993 ◽  
Vol 38 (1) ◽  
pp. 16-17 ◽  
Author(s):  
D.M. Tappin ◽  
R.W.A. Girdwood ◽  
E.A.C. Follett ◽  
R. Kennedy ◽  
A.J. Brown ◽  
...  

In January 1990, unlinked anonymous testing of Guthrie cards for HIV antibody commenced in Scotland. Ethics Committee approval allowed testing of 99.6% of Scottish births. Twenty-one mothers spontaneously refused to allow testing of their baby's blood. Samples were coded by district postcodes. For 1990 through 1991, eluates of 132,531 dried blood spots were initially tested for HIV-1 antibody with the Fujirebio technique. Of the 49 positive samples 38 were confirmed to be positive by enzyme-linked immunosorbent assay and western blot (seroprevalence 0.3 per 1000). Thirty-five of 38 samples came from large metropolitan areas in Scotland. Prevalences were 2.0 per 1000 for Edinburgh city, 0.7 per 1000 for Dundee and Aberdeen, 0.15 per 1000 for Glasgow and 0.05 per thousand for all other areas in Scotland. Recent spread of HIV infection to Aberdeen may have occurred. These figures do not support an overall increase of HIV infection in childbearing women in Scotland.


The Lancet ◽  
1990 ◽  
Vol 335 (8688) ◽  
pp. 516-519 ◽  
Author(s):  
C.S Peckham ◽  
A.E Ades ◽  
C O'Connor ◽  
R.S Tedder ◽  
M Briggs ◽  
...  

1990 ◽  
Vol 153 (7) ◽  
pp. 383-386 ◽  
Author(s):  
Mary‐Louise McLaws ◽  
David A Cooper ◽  
Andrew R D Brown ◽  
Bridget Wilcken ◽  
Phillip H. Cunningham ◽  
...  

1997 ◽  
Vol 11 (4) ◽  
pp. 447-461 ◽  
Author(s):  
Beth A. Kotchick ◽  
Rex Forehand ◽  
Gene Brody ◽  
Lisa Armistead ◽  
Patricia Simon ◽  
...  

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Joan T PRICE ◽  
Bellington VWALIKA ◽  
Jessie K EDWARDS ◽  
Stephen R COLE ◽  
Margaret P KASARO ◽  
...  

Author(s):  
Rashmi S. Desai ◽  
Geetha Shivamurthy ◽  
Sameer Desai

Background: The effect of HIV on obstetric complications is known to vary across regions of world. The variation may be due to HIV infection per se or it may be due to complex interaction of related medical and social conditions that affect pregnancy. Incidence of these obstetric complications in HIV infected pregnant women is not well reported in India. So, this prospective cohort study was carried to observe the demographics and incidence of obstetrics complications like abortions, still birth, premature rupture of membranes, preterm delivery, opportunistic infections in HIV infected pregnant women.Methods: All pregnant women who were screened positive for HIV test, irrespective of their gestational age were included in the study. Apart from routine obstetric care, CD4 cell count was carried out. The patients were followed up till term, delivery and up to 6-week postpartum period. Obstetric outcomes like incidence of abortion, intrauterine death, preterm delivery and premature rupture of membrane were noted. Baby`s birth weight and the incidence of maternal opportunistic infection were noted and correlated with maternal CD4 cell count.Results: Maternal HIV infection is associated pre-term labour in 34.5%, PROM in 30%, low birth weight in 52.3%. Increased incidences of these adverse outcomes have an inverse relationship with CD4 count.Conclusions: Maternal HIV infection is associated with increased incidence of adverse obstetric outcome and opportunistic infection, and their incidences increase with lower CD4 count.


2019 ◽  
Author(s):  
Halima Sumayya Twabi ◽  
Samuel O Manda ◽  
Dylan S Small

Abstract Evidence has shown that maternal HIV infection has adverse effects on child birth weight. However, the effect of anti-retroviral therapy (ART) on pregnancy outcome is not conclusive. Ascertaining causality of these associations remain largely unexamined and untested, and if confirmed would help policy makers to improve implementation and sensitization of PMTCT program. However, assessing causal effect has been limited due to ethical concerns if randomized controlled trials are appropriate. We aim to estimate the causal effect of maternal HIV on birth weight and the causal effect of knowledge of HIV status on exclusive breastfeeding while ascertaining the mediating effect of ART using observational data. Data on over 18,000 and 16,000 children still alive and born within five years of the 2010 and 2015-16 Malawi Demographic and Health Surveys were analysed. A set of methods for confounder balance namely, the 1:1 nearest neighbour (NN) matching, matching on the propensity score (PS) and inverse weighting the propensity score (PS) were used. Before matching, place of residence, region, anaemia level and age were statistically different between HIV-infected and HIV-uninfected mothers for both the 2010 and 2015-16 data. After matching, the selected confounding variables were distributed similarly between HIV-infection statuses. Maternal HIV infection had a negative effect on infant birth weight for the 2010 data and had a positive effect on birth weight for the 2015-16 data with p-values <0.001. Uptake of ART did not mediate the effect of HIV infection on birth weight. Maternal knowledge of HIV status was not associated with behaviour concerning exclusive breastfeeding. We have found conflicting evidence on the association between maternal HIV infection and birth weight. The adverse association between maternal HIV infection and child birth weight found for the 2010 data could more likely be causal. However, the increased birth weight among infants born to HIV infected mothers in 2015-16 may show the recent successes of policies and interventions within the PMTCT program in Malawi. However, the purported mediating effect of ART on the association between HIV infection and birth weight was not found. Prenatal care interventions should continue to be supported among ANC clinics in Malawi.


AIDS ◽  
1990 ◽  
Vol 4 (10) ◽  
pp. 1001-1006 ◽  
Author(s):  
Michael R. Braddick ◽  
Joan K. Kreiss ◽  
Joanne E. Embree ◽  
Pratibha Datta ◽  
Jack O. Ndinya-Achola ◽  
...  

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